| Literature DB >> 23380586 |
Rongzhen Zhang1, Robert G Miller, Catherine Madison, Xia Jin, Ronald Honrada, Will Harris, Jonathan Katz, Dallas A Forshew, Michael S McGrath.
Abstract
Immune activation and inflammation play significant roles in the pathogenesis of Alzheimer's disease (AD). To test whether AD patients showed systemic manifestations of inflammation, blood from 41 patients with early stages of AD and 31 aged-match elderly controls were evaluated. Cellular markers for monocyte/macrophage (MO) activation and CD8 T lymphocyte were increased in early AD patients. Expression of monocyte CCR2, the receptor for monocyte chemoattractant protein-1 (MCP-1), was decreased; however, plasma MCP-1 levels were significantly increased and were related to the degree of MO activation in AD. These findings suggest that AD pathogenesis may be influenced by systemic immunologic dysfunction and provides potential immunologic targets for therapeutic intervention. Published by Elsevier B.V.Entities:
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Year: 2013 PMID： 23380586 PMCID： PMC3641776 DOI： 10.1016/j.jneuroim.2013.01.002
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478