Literature DB >> 23379526

New titin (connectin) isoforms and their functional role in striated muscles of mammals: facts and suppositions.

I M Vikhlyantsev1, Z A Podlubnaya.   

Abstract

This review summarizes results of our studies on titin isoform composition in vertebrate striated muscles under normal conditions, during hibernation, real and simulated microgravity, and under pathological conditions (stiff-person syndrome, post-apoplectic spasticity, dilated cardiomyopathy, cardiac hypertrophy). Experimental evidence for the existence in mammalian striated muscles of higher molecular weight isoforms of titin (NT-isoforms) in addition to the known N2A-, N2BA-, and N2B-titin isoforms was obtained. Comparative studies of changes in titin isoform composition and structure-functional properties of human and animal striated muscles during adaptive and pathological processes led to a conclusion about the key role of NT-isoforms of titin in maintenance of sarcomere structure and contractile function of these muscles.

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Year:  2012        PMID： 23379526     DOI： 10.1134/S0006297912130093

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  10 in total

1.  Inhibition of Histone Deacetylases 4 and 5 Reduces Titin Proteolysis and Prevents Reduction of TTN Gene Expression in Atrophied Rat Soleus Muscle after Seven-Day Hindlimb Unloading.

Authors:  Yu V Gritsyna; A D Ulanova; S S Popova; A G Bobylev; V K Zhalimov; T L Nemirovskaya; B S Shenkman; I M Vikhlyantsev
Journal:  Dokl Biochem Biophys       Date:  2020-12-25       Impact factor: 0.788

2.  Seasonal changes in proteolytic activity of calpains in striated muscles of long-tailed ground squirrel Spermophilus undulatus.

Authors:  S S Popova; I M Vikhlyantsev; N M Zakharova; Z A Podlubnaya; E E Fesenko
Journal:  Dokl Biochem Biophys       Date:  2017-04-19       Impact factor: 0.788

Review 3.  Pre-mRNA mis-splicing of sarcomeric genes in heart failure.

Authors:  Chaoqun Zhu; Zhilong Chen; Wei Guo
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2016-11-05       Impact factor: 5.187

Review 4.  Nuances of electrophoresis study of titin/connectin.

Authors:  Ivan M Vikhlyantsev; Zoya A Podlubnaya
Journal:  Biophys Rev       Date:  2017-05-29

5.  Beneficial Effects of Cardiomyopathy-Associated Genetic Variants on Physical Performance: A Hypothesis-Generating Scoping Review.

Authors:  Sjoerd M Verwijs; Yigal M Pinto; Diederik W D Kuster; Jolanda van der Velden; Jacqueline Limpens; Juliette C van Hattum; Saskia N van der Crabben; Ronald H Lekanne Deprez; Arthur A M Wilde; Harald T Jørstad
Journal:  Cardiology       Date:  2021-10-27       Impact factor: 1.869

6.  Effects of low-level laser therapy (LLLT 808 nm) on lower limb spastic muscle activity in chronic stroke patients.

Authors:  Marcele Florêncio das Neves; Mariana César Ribeiro Dos Reis; Eliana Aparecida Fonseca de Andrade; Fernanda Pupio Silva Lima; Renata Amadei Nicolau; Emília Ângela Loschiavo Arisawa; Adriano Oliveira Andrade; Mário Oliveira Lima
Journal:  Lasers Med Sci       Date:  2016-05-31       Impact factor: 3.161

7.  Isoform composition and gene expression of thick and thin filament proteins in striated muscles of mice after 30-day space flight.

Authors:  Anna Ulanova; Yulia Gritsyna; Ivan Vikhlyantsev; Nikolay Salmov; Alexander Bobylev; Zarema Abdusalamova; Vadim Rogachevsky; Boris Shenkman; Zoya Podlubnaya
Journal:  Biomed Res Int       Date:  2015-01-18       Impact factor: 3.411

8.  Identification of genetic association between cardiorespiratory fitness and the trainability genes in childhood acute lymphoblastic leukemia survivors.

Authors:  Maxime Caru; Kateryna Petrykey; Simon Drouin; Patrick Beaulieu; Pascal St-Onge; Valérie Lemay; Laurence Bertout; Caroline Laverdiere; Gregor Andelfinger; Maja Krajinovic; Daniel Sinnett; Daniel Curnier
Journal:  BMC Cancer       Date:  2019-05-14       Impact factor: 4.430

9.  TTN mutations predict a poor prognosis in patients with thyroid cancer.

Authors:  Xiudan Han; Jianrong Chen; Jiao Wang; Jixiong Xu; Ying Liu
Journal:  Biosci Rep       Date:  2022-07-29       Impact factor: 3.976

10.  Smooth muscle titin forms in vitro amyloid aggregates.

Authors:  Alexandr G Bobylev; Oxana V Galzitskaya; Roman S Fadeev; Liya G Bobyleva; Darya A Yurshenas; Nikolay V Molochkov; Nikita V Dovidchenko; Olga M Selivanova; Nikita V Penkov; Zoya A Podlubnaya; Ivan M Vikhlyantsev
Journal:  Biosci Rep       Date:  2016-05-20       Impact factor: 3.840
  10 in total

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