OBJECTIVE: To compare characteristics of autoantibody (aAb)-positive and -negative cases of type 1 diabetes (T1D) <18 years old in the T1D Exchange clinic registry. METHODS: An aAb-positive status (n = 6239) required at least one of the aAbs to be positive; an aAb-negative status (n = 485) required negative results on testing of at least two different aAbs. RESULTS: The percentage of males was higher (58% vs. 51%; P = 0.002) and total daily insulin dose lower (P = 0.003) in aAb-negative compared with aAb-positive groups, but both groups had similar distributions of race-ethnicity, diagnosis age, family history of T1D, ketoacidosis at diagnosis, body mass index at diagnosis and at most recent office visit, and current HbA1c. CONCLUSIONS: Male gender and lower total daily insulin dose were more likely in aAb-negative than aAb-positive children with T1D, but no other distinguishing characteristics were identified. Further examination of characteristics of aAb-negative cases may help characterize the heterogeneous nature of T1D.
OBJECTIVE: To compare characteristics of autoantibody (aAb)-positive and -negative cases of type 1 diabetes (T1D) <18 years old in the T1D Exchange clinic registry. METHODS: An aAb-positive status (n = 6239) required at least one of the aAbs to be positive; an aAb-negative status (n = 485) required negative results on testing of at least two different aAbs. RESULTS: The percentage of males was higher (58% vs. 51%; P = 0.002) and total daily insulin dose lower (P = 0.003) in aAb-negative compared with aAb-positive groups, but both groups had similar distributions of race-ethnicity, diagnosis age, family history of T1D, ketoacidosis at diagnosis, body mass index at diagnosis and at most recent office visit, and current HbA1c. CONCLUSIONS: Male gender and lower total daily insulin dose were more likely in aAb-negative than aAb-positive children with T1D, but no other distinguishing characteristics were identified. Further examination of characteristics of aAb-negative cases may help characterize the heterogeneous nature of T1D.
Authors: Shihab Hameed; Sian Ellard; Helen J Woodhead; Kristen A Neville; Jan L Walker; Maria E Craig; Taylor Armstrong; Liping Yu; George S Eisenbarth; Andrew T Hattersley; Charles F Verge Journal: Pediatr Diabetes Date: 2010-09-06 Impact factor: 4.866
Authors: Maciej Borowiec; Wojciech Fendler; Karolina Antosik; Anna Ciepiela; Anna Baranowska; Anna Hogendorf; Beata Mianowska; Agnieszka Szadkowska; Wojciech Młynarski Journal: Pediatr Endocrinol Diabetes Metab Date: 2010
Authors: Mikael Knip; Sari Korhonen; Petri Kulmala; Riitta Veijola; Antti Reunanen; Olli T Raitakari; Jorma Viikari; Hans K Akerblom Journal: Diabetes Care Date: 2010-06 Impact factor: 19.112
Authors: Sven Pörksen; Lene Bjerke Laborie; Lotte Nielsen; Marie Louise Max Andersen; Tone Sandal; Heidi de Wet; Erik Schwarcz; Jan Aman; Peter Swift; Mirjana Kocova; Eugen J Schönle; Carine de Beaufort; Philip Hougaard; Frances Ashcroft; Anders Molven; Mikael Knip; Henrik B Mortensen; Lars Hansen; Pål R Njølstad Journal: BMC Endocr Disord Date: 2010-09-23 Impact factor: 2.763