| Literature DB >> 23365962 |
Yanyan Zhang1, Christopher B Ballas, Masaru P Rao.
Abstract
We describe a massively-parallelized, MEMS-based device concept for passively delivering exogeneous molecules into living cells via mechanical membrane penetration, i.e., mechanoporation. Details regarding device design and fabrication are discussed, as are results from preliminary live cell studies focused on device validation at the proof-of-concept level. These efforts represent key steps towards our long-term goal of developing instrumentation capable of ultrahigh throughput (UHT) cellular manipulation via active microinjection.Entities:
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Year: 2012 PMID： 23365962 PMCID： PMC4492306 DOI： 10.1109/EMBC.2012.6346001
Source DB: PubMed Journal: Conf Proc IEEE Eng Med Biol Soc ISSN： 1557-170X