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Literature DB >> 23365452

The human papillomavirus type 8 E6 protein interferes with NOTCH activation during keratinocyte differentiation.

Jordan M Meyers¹, Jennifer M Spangle, Karl Munger.

Abstract

Cutaneous β-human papillomavirus (β-HPV) E6 proteins inhibit NOTCH signaling by associating with the transcriptional coactivator MAML1. NOTCH has tumor suppressor activities in epithelial cells and is activated during keratinocyte differentiation. Here we report that HPV type 8 (HPV8) E6 subverts NOTCH activation during keratinocyte differentiation by inhibiting RBPJ/MAML1 transcriptional activator complexes at NOTCH target DNA. NOTCH inhibition impairs epithelial differentiation and may thus contribute to β-HPV replication and viral oncogenesis.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23365452 PMCID： PMC3624394 DOI： 10.1128/JVI.02527-12

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

20 in total

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Journal: Proc Natl Acad Sci U S A Date: 2011-04-25 Impact factor: 11.205

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Authors: Min Jie Alvin Tan; Elizabeth A White; Mathew E Sowa; J Wade Harper; Jon C Aster; Peter M Howley
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3. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.

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Review 4. Notch-signaling and nonmelanoma skin cancer: an ancient friend, revisited.

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Journal: Adv Exp Med Biol Date: 2012 Impact factor: 2.622

5. Human papillomavirus 8 E6 disrupts terminal skin differentiation and prevents pro-Caspase-14 cleavage.

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Journal: Curr Opin Virol Date: 2012-06-02 Impact factor: 7.090

Review 7. Viral-associated nonmelanoma skin cancers: a review.

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10. Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling.

Authors: N Brimer; C Lyons; A E Wallberg; S B Vande Pol
Journal: Oncogene Date: 2012-01-16 Impact factor: 9.867

44 in total

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Authors: Peter M Howley; Herbert J Pfister
Journal: Virology Date: 2015-02-24 Impact factor: 3.616

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Authors: Scott B Vande Pol; Aloysius J Klingelhutz
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Review 3. Notch as a tumour suppressor.

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Review 4. Viruses and human cancers: a long road of discovery of molecular paradigms.

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Review 5. Effects of β-HPV on DNA damage response pathways to drive carcinogenesis: a review.

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Journal: Virus Genes Date: 2021-01-03 Impact factor: 2.332

6. Alcohol drinking inhibits NOTCH-PAX9 signaling in esophageal squamous epithelial cells.

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Journal: J Pathol Date: 2021-01-18 Impact factor: 7.996

7. Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation.

Authors: Marcel Chris Conrady; Irina Suarez; Gergö Gogl; Desiree Isabella Frecot; Anna Bonhoure; Camille Kostmann; Alexandra Cousido-Siah; André Mitschler; JiaWen Lim; Murielle Masson; Thomas Iftner; Frank Stubenrauch; Gilles Travé; Claudia Simon
Journal: J Virol Date: 2020-12-22 Impact factor: 5.103