BACKGROUND: Understanding adherence to bone mineral density (BMD) screening after breast cancer (BC) treatment with aromatase inhibitors (AI) is an important first step in preventing or treating BC-related osteoporosis. METHODS: This retrospective cohort study assessed receipt and adherence to BMD screening among 342 women diagnosed with BC who were at high risk for osteoporosis after BC treatment with AI between 2004 and 2007. Nonadherence to baseline and annual BMD screening (recommended by 2003 American Society of Clinical Oncology Guidelines) was assessed using descriptive statistics and Poisson regression models accounting for length of AI use and follow-up. RESULTS: In the year before AI initiation, 16% of women received BMD screening. Fifty-six percent had no BMD screening in the 14 months after a minimum of 9 months of continuous AI use, and 75% and 66% failed to have BMD screens during the second (14.1-26 month) and third (26.1-38 month) annual time periods after continuous AI use for at least 23 and 35 months, respectively. Overall, 24% had no BMD screening after 35 months of continuous AI use. Statistically significant predictors of nonadherence included predominant exemestane use, BMD screening before AI initiation, and diabetes mellitus history. Postcollege education, geographic region of primary care clinic, and never smoking were associated with a reduced risk of nonadherence. CONCLUSIONS: A significant proportion of breast cancer patients treated with AI did not receive guideline-recommended BMD screening. Findings should raise awareness of the importance of BMD screening and targeting women at increased risk of screening nonadherence.
BACKGROUND: Understanding adherence to bone mineral density (BMD) screening after breast cancer (BC) treatment with aromatase inhibitors (AI) is an important first step in preventing or treating BC-related osteoporosis. METHODS: This retrospective cohort study assessed receipt and adherence to BMD screening among 342 women diagnosed with BC who were at high risk for osteoporosis after BC treatment with AI between 2004 and 2007. Nonadherence to baseline and annual BMD screening (recommended by 2003 American Society of Clinical Oncology Guidelines) was assessed using descriptive statistics and Poisson regression models accounting for length of AI use and follow-up. RESULTS: In the year before AI initiation, 16% of women received BMD screening. Fifty-six percent had no BMD screening in the 14 months after a minimum of 9 months of continuous AI use, and 75% and 66% failed to have BMD screens during the second (14.1-26 month) and third (26.1-38 month) annual time periods after continuous AI use for at least 23 and 35 months, respectively. Overall, 24% had no BMD screening after 35 months of continuous AI use. Statistically significant predictors of nonadherence included predominant exemestane use, BMD screening before AI initiation, and diabetes mellitus history. Postcollege education, geographic region of primary care clinic, and never smoking were associated with a reduced risk of nonadherence. CONCLUSIONS: A significant proportion of breast cancerpatients treated with AI did not receive guideline-recommended BMD screening. Findings should raise awareness of the importance of BMD screening and targeting women at increased risk of screening nonadherence.
Authors: Daniel H Solomon; M Alan Brookhart; Tejal K Gandhi; Andrew Karson; Soheyla Gharib; E John Orav; Shimon Shaykevich; Andrea Licari; Danielle Cabral; David W Bates Journal: Am J Med Date: 2004-12-15 Impact factor: 4.965
Authors: Denise M Boudreau; Elizabeth Koehler; Stephen J Rulyak; Sebastien Haneuse; Robert Harrison; Margaret T Mandelson Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-10-28 Impact factor: 4.254
Authors: David M Reid; Julie Doughty; Richard Eastell; Steven D Heys; Anthony Howell; Eugene V McCloskey; Trevor Powles; Peter Selby; Robert E Coleman Journal: Cancer Treat Rev Date: 2008-06-02 Impact factor: 12.111
Authors: Roberta De Angelis; Andrea Tavilla; Arduino Verdecchia; Steve Scoppa; Mark Hachey; Eric J Feuer; Angela B Mariotto Journal: Cancer Date: 2009-05-01 Impact factor: 6.860
Authors: B M Psaty; S R Heckbert; T D Koepsell; D S Siscovick; T E Raghunathan; N S Weiss; F R Rosendaal; R N Lemaitre; N L Smith; P W Wahl Journal: JAMA Date: 1995 Aug 23-30 Impact factor: 56.272
Authors: N C W Harvey; E V McCloskey; P J Mitchell; B Dawson-Hughes; D D Pierroz; J-Y Reginster; R Rizzoli; C Cooper; J A Kanis Journal: Osteoporos Int Date: 2017-02-07 Impact factor: 4.507
Authors: Marilyn L Kwan; Joan C Lo; Li Tang; Cecile A Laurent; Janise M Roh; Malini Chandra; Theresa E Hahn; Chi-Chen Hong; Lara Sucheston-Campbell; Dawn L Hershman; Charles P Quesenberry; Christine B Ambrosone; Lawrence H Kushi; Song Yao Journal: PLoS One Date: 2014-10-29 Impact factor: 3.240