| Literature DB >> 23360175 |
Patrick Holton1, Mina Ryten, Michael Nalls, Daniah Trabzuni, Michael E Weale, Dena Hernandez, Helen Crehan, J Raphael Gibbs, Richard Mayeux, Jonathan L Haines, Lindsay A Farrer, Margaret A Pericak-Vance, Gerard D Schellenberg, Manuel Ramirez-Restrepo, Anzhelika Engel, Amanda J Myers, Jason J Corneveaux, Matthew J Huentelman, Allissa Dillman, Mark R Cookson, Eric M Reiman, Andrew Singleton, John Hardy, Rita Guerreiro.
Abstract
Recent genome wide association studies have identified CLU, CR1, ABCA7 BIN1, PICALM and MS4A6A/MS4A6E in addition to the long established APOE, as loci for Alzheimer's disease. We have systematically examined each of these loci to assess whether common coding variability contributes to the risk of disease. We have also assessed the regional expression of all the genes in the brain and whether there is evidence of an eQTL explaining the risk. In agreement with other studies we find that coding variability may explain the ABCA7 association, but common coding variability does not explain any of the other loci. We were not able to show that any of the loci had eQTLs within the power of this study. Furthermore the regional expression of each of the loci did not match the pattern of brain regional distribution in Alzheimer pathology. Although these results are mainly negative, they allow us to start defining more realistic alternative approaches to determine the role of all the genetic loci involved in Alzheimer's disease.Entities:
Mesh：
Year: 2013 PMID： 23360175 PMCID： PMC3578142 DOI： 10.1111/ahg.12000
Source DB: PubMed Journal: Ann Hum Genet ISSN： 0003-4800 Impact factor: 1.670