| Literature DB >> 23359715 |
Alexi Nott1, Justyna Nitarska, Jesse V Veenvliet, Stephan Schacke, Alwin A H A Derijck, Piotr Sirko, Christian Muchardt, R Jeroen Pasterkamp, Marten P Smidt, Antonella Riccio.
Abstract
Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons.Entities:
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Year: 2013 PMID： 23359715 PMCID： PMC3581896 DOI： 10.1073/pnas.1218126110
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205