Literature DB >> 23358218

Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C.

David Booth1, Jacob George.   

Abstract

Attempts to elucidate the mechanism underpinning the genetic association between IFNL3, previously called IL28B, and clearance of hepatitis C virus have, by and large, been unsuccessful. A study in this issue suggests that a new gene, IFNL4, may be responsible.

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Year:  2013        PMID： 23358218     DOI： 10.1038/ng.2537

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  11 in total

1.  Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.

Authors:  Masao Honda; Akito Sakai; Tatsuya Yamashita; Yasunari Nakamoto; Eishiro Mizukoshi; Yoshio Sakai; Taro Yamashita; Mikiko Nakamura; Takayoshi Shirasaki; Katsuhisa Horimoto; Yasuhito Tanaka; Katsushi Tokunaga; Masashi Mizokami; Shuichi Kaneko
Journal:  Gastroenterology       Date:  2010-04-29       Impact factor: 22.682

2.  Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C.

Authors:  Tom W Chu; Rohit Kulkarni; Edward J Gane; Stuart K Roberts; Catherine Stedman; Peter W Angus; Brett Ritchie; Xiao-Yu Lu; David Ipe; Uri Lopatin; Soren Germer; Victor A Iglesias; Robert Elston; Patrick F Smith; Nancy S Shulman
Journal:  Gastroenterology       Date:  2012-01-13       Impact factor: 22.682

3.  A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.

Authors:  Ludmila Prokunina-Olsson; Brian Muchmore; Wei Tang; Ruth M Pfeiffer; Heiyoung Park; Harold Dickensheets; Dianna Hergott; Patricia Porter-Gill; Adam Mumy; Indu Kohaar; Sabrina Chen; Nathan Brand; McAnthony Tarway; Luyang Liu; Faruk Sheikh; Jacquie Astemborski; Herbert L Bonkovsky; Brian R Edlin; Charles D Howell; Timothy R Morgan; David L Thomas; Barbara Rehermann; Raymond P Donnelly; Thomas R O'Brien
Journal:  Nat Genet       Date:  2013-01-06       Impact factor: 38.330

4.  Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.

Authors:  Michael T Dill; Francois H T Duong; Julia E Vogt; Stéphanie Bibert; Pierre-Yves Bochud; Luigi Terracciano; Andreas Papassotiropoulos; Volker Roth; Markus H Heim
Journal:  Gastroenterology       Date:  2010-11-25       Impact factor: 22.682

5.  IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.

Authors:  Thomas J Urban; Alexander J Thompson; Shelton S Bradrick; Jacques Fellay; Detlef Schuppan; Kenneth D Cronin; Linda Hong; Alexander McKenzie; Keyur Patel; Kevin V Shianna; John G McHutchison; David B Goldstein; Nezam Afdhal
Journal:  Hepatology       Date:  2010-10-07       Impact factor: 17.425

6.  Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.

Authors:  Andri Rauch; Zoltán Kutalik; Patrick Descombes; Tao Cai; Julia Di Iulio; Tobias Mueller; Murielle Bochud; Manuel Battegay; Enos Bernasconi; Jan Borovicka; Sara Colombo; Andreas Cerny; Jean-François Dufour; Hansjakob Furrer; Huldrych F Günthard; Markus Heim; Bernard Hirschel; Raffaele Malinverni; Darius Moradpour; Beat Müllhaupt; Andrea Witteck; Jacques S Beckmann; Thomas Berg; Sven Bergmann; Francesco Negro; Amalio Telenti; Pierre-Yves Bochud
Journal:  Gastroenterology       Date:  2010-01-11       Impact factor: 22.682

7.  Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: impaired viral kinetics and therapeutic response.

Authors:  Susanna Naggie; Anu Osinusi; Antonios Katsounas; Richard Lempicki; Eva Herrmann; Alexander J Thompson; Paul J Clark; Keyur Patel; Andrew J Muir; John G McHutchison; Joerg F Schlaak; Martin Trippler; Bhavana Shivakumar; Henry Masur; Michael A Polis; Shyam Kottilil
Journal:  Hepatology       Date:  2012-07-02       Impact factor: 17.425

8.  Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.

Authors:  Dongliang Ge; Jacques Fellay; Alexander J Thompson; Jason S Simon; Kevin V Shianna; Thomas J Urban; Erin L Heinzen; Ping Qiu; Arthur H Bertelsen; Andrew J Muir; Mark Sulkowski; John G McHutchison; David B Goldstein
Journal:  Nature       Date:  2009-08-16       Impact factor: 49.962

9.  Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.

Authors:  Yasuhito Tanaka; Nao Nishida; Masaya Sugiyama; Masayuki Kurosaki; Kentaro Matsuura; Naoya Sakamoto; Mina Nakagawa; Masaaki Korenaga; Keisuke Hino; Shuhei Hige; Yoshito Ito; Eiji Mita; Eiji Tanaka; Satoshi Mochida; Yoshikazu Murawaki; Masao Honda; Akito Sakai; Yoichi Hiasa; Shuhei Nishiguchi; Asako Koike; Isao Sakaida; Masatoshi Imamura; Kiyoaki Ito; Koji Yano; Naohiko Masaki; Fuminaka Sugauchi; Namiki Izumi; Katsushi Tokunaga; Masashi Mizokami
Journal:  Nat Genet       Date:  2009-09-13       Impact factor: 38.330

10.  IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.

Authors:  Vijayaprakash Suppiah; Max Moldovan; Golo Ahlenstiel; Thomas Berg; Martin Weltman; Maria Lorena Abate; Margaret Bassendine; Ulrich Spengler; Gregory J Dore; Elizabeth Powell; Stephen Riordan; David Sheridan; Antonina Smedile; Vincenzo Fragomeli; Tobias Müller; Melanie Bahlo; Graeme J Stewart; David R Booth; Jacob George
Journal:  Nat Genet       Date:  2009-09-13       Impact factor: 38.330
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  15 in total

1.  Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.

Authors:  Pauline Ferraris; Partha K Chandra; Rajesh Panigrahi; Fatma Aboulnasr; Srinivas Chava; Ramazan Kurt; Jean-Michel Pawlotsky; Ludwig Wilkens; Pamela Osterlund; Rune Hartmann; Luis A Balart; Tong Wu; Srikanta Dash
Journal:  Am J Pathol       Date:  2016-02-16       Impact factor: 4.307

Review 2.  Dendritic cells in hepatitis C virus infection: key players in the IFNL3-genotype response.

Authors:  Kate S O'Connor; Jacob George; David Booth; Golo Ahlenstiel
Journal:  World J Gastroenterol       Date:  2014-12-21       Impact factor: 5.742

Review 3.  Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactions.

Authors:  Sreedhar Chinnaswamy
Journal:  J Interferon Cytokine Res       Date:  2014-02-20       Impact factor: 2.607

Review 4.  Hepatitis C virus protease inhibitor-resistance mutations: our experience and review.

Authors:  Shuang Wu; Tatsuo Kanda; Shingo Nakamoto; Fumio Imazeki; Osamu Yokosuka
Journal:  World J Gastroenterol       Date:  2013-12-21       Impact factor: 5.742

Review 5.  Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design.

Authors:  Alexander W Tarr; Tanvi Khera; Kathrin Hueging; Julie Sheldon; Eike Steinmann; Thomas Pietschmann; Richard J P Brown
Journal:  Viruses       Date:  2015-07-17       Impact factor: 5.048

6.  Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection.

Authors:  Janett Fischer; Stephan Böhm; Tobias Müller; Heiko Witt; Christoph Sarrazin; Simone Susser; Pascal Migaud; Eckart Schott; Graeme Stewart; Annika Brodzinski; Balazs Fülöp; Florian van Bömmel; Jacob George; Thomas Berg
Journal:  PLoS One       Date:  2013-10-29       Impact factor: 3.240

7.  IL-28B is a key regulator of B- and T-cell vaccine responses against influenza.

Authors:  Adrian Egli; Deanna M Santer; Daire O'Shea; Khaled Barakat; Mohammedyaseen Syedbasha; Madeleine Vollmer; Aliyah Baluch; Rakesh Bhat; Jody Groenendyk; Michael A Joyce; Luiz F Lisboa; Brad S Thomas; Manuel Battegay; Nina Khanna; Thomas Mueller; D Lorne J Tyrrell; Michael Houghton; Atul Humar; Deepali Kumar
Journal:  PLoS Pathog       Date:  2014-12-11       Impact factor: 6.823

8.  Interferon lambda 4 expression is suppressed by the host during viral infection.

Authors:  MeeAe Hong; Johannes Schwerk; Chrissie Lim; Alison Kell; Abigail Jarret; Joseph Pangallo; Yueh-Ming Loo; Shuanghu Liu; Curt H Hagedorn; Michael Gale; Ram Savan
Journal:  J Exp Med       Date:  2016-10-31       Impact factor: 14.307

9.  Hepatitis C virus infection and spontaneous clearance in HTLV-1 and HIV co-infected patients in Salvador, Bahia, Brazil.

Authors:  Chloe Le Marchand; Fabianna Bahia; Kimberly Page; Carlos Brites
Journal:  Braz J Infect Dis       Date:  2015-08-05       Impact factor: 1.949

10.  Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses.

Authors:  Ole J Hamming; Ewa Terczyńska-Dyla; Gabrielle Vieyres; Ronald Dijkman; Sanne E Jørgensen; Hashaam Akhtar; Piotr Siupka; Thomas Pietschmann; Volker Thiel; Rune Hartmann
Journal:  EMBO J       Date:  2013-10-29       Impact factor: 11.598
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