Literature DB >> 2335783

Changes in brain energy and phospholipid metabolism during development and aging in the Fischer 344 rat.

J W Pettegrew1, K Panchalingam, G Withers, D McKeag, S Strychor.   

Abstract

The effects of brain development and aging on high-energy phosphate and membrane phospholipid metabolism were studied from birth to senescence in the Fischer 344 rat using 31P nuclear magnetic resonance spectroscopy. Marked developmental and smaller aging-related changes were observed in brain high-energy phosphates, phospholipid precursors and phospholipid breakdown products. The biochemical changes correlate with known histological and electrophysiological changes occurring in the brain during development (neuritic sprouting and onset of brain electrical activity) and aging (loss of dendritic processes). These findings provide a framework for interpreting the effects of physiological insults during different developmental and aging periods.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2335783     DOI： 10.1097/00005072-199005000-00005

Source DB:  PubMed          Journal:  J Neuropathol Exp Neurol        ISSN： 0022-3069            Impact factor:   3.685


  15 in total

1.  Brain metabolic effects of acute nicotine.

Authors:  J W Pettegrew; K Panchalingam; R J McClure; J Levine
Journal:  Neurochem Res       Date:  2001-02       Impact factor: 3.996

2.  Neuropil pruning in Early-Course Schizophrenia: Immunological, Clinical, and Neurocognitive Correlates.

Authors:  Konasale M Prasad; Ashley M Burgess; Matcheri S Keshavan; Vishwajit L Nimgaonkar; Jeffrey A Stanley
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2016-11

3.  Regionally Distinct Alterations in Membrane Phospholipid Metabolism in Schizophrenia: A Meta-analysis of Phosphorus Magnetic Resonance Spectroscopy Studies.

Authors:  Connor S Haszto; Jeffrey A Stanley; Satish Iyengar; Konasale M Prasad
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2019-10-01

4.  In Vivo Neurochemical Characterization of Developing Guinea Pigs and the Effect of Chronic Fetal Hypoxia.

Authors:  Wen-Tung Wang; Phil Lee; Yafeng Dong; Hung-Wen Yeh; Jieun Kim; Carl P Weiner; William M Brooks; In-Young Choi
Journal:  Neurochem Res       Date:  2016-05-27       Impact factor: 3.996

5.  Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain.

Authors:  Susanna Scafidi; Jennifer Racz; Julie Hazelton; Mary C McKenna; Gary Fiskum
Journal:  Dev Neurosci       Date:  2011-01-12       Impact factor: 2.984

6.  Brain membrane phospholipid alterations in Alzheimer's disease.

Authors:  J W Pettegrew; K Panchalingam; R L Hamilton; R J McClure
Journal:  Neurochem Res       Date:  2001-07       Impact factor: 3.996

7.  Iron supplementation dose for perinatal iron deficiency differentially alters the neurochemistry of the frontal cortex and hippocampus in adult rats.

Authors:  Raghavendra Rao; Ivan Tkac; Erica L Unger; Kathleen Ennis; Amy Hurst; Timothy Schallert; James Connor; Barbara Felt; Michael K Georgieff
Journal:  Pediatr Res       Date:  2012-10-24       Impact factor: 3.756

8.  High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging.

Authors:  Janna L Harris; Hung-Wen Yeh; Russell H Swerdlow; In-Young Choi; Phil Lee; William M Brooks
Journal:  Neurobiol Aging       Date:  2014-01-23       Impact factor: 4.673

9.  Evidence of developmental alterations in cortical and subcortical regions of children with attention-deficit/hyperactivity disorder: a multivoxel in vivo phosphorus 31 spectroscopy study.

Authors:  Jeffrey A Stanley; Heidi Kipp; Erika Greisenegger; Frank P MacMaster; K Panchalingam; Matcheri S Keshavan; Oscar G Bukstein; Jay W Pettegrew
Journal:  Arch Gen Psychiatry       Date:  2008-12

10.  31P magnetic resonance spectroscopy of the medial temporal lobe of schizophrenic patients with neuroleptic-resistant marked positive symptoms.

Authors:  H Fukuzako; K Takeuchi; K Ueyama; T Fukuzako; Y Hokazono; K Hirakawa; K Yamada; T Hashiguchi; M Takigawa; T Fujimoto
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1994       Impact factor: 5.270
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.