Literature DB >> 23357635

Synthesis and antitubercular activity of amino alcohol fused spirochromone conjugates.

M Mujahid1, R G Gonnade, P Yogeeswari, D Sriram, M Muthukrishnan.   

Abstract

A series of 21 new amino alcohol fused spirochromone conjugates have been synthesized, characterized with analytical data and evaluated their antimycobacterial activity against Mycobacterium tuberculosis (virulent strain H37Rv) in vitro. Some of the compounds exerted significant inhibition, in particular, compound 4f found to be the most potent derivative exhibiting MIC=3.13 μg/mL.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23357635     DOI： 10.1016/j.bmcl.2012.12.073

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Bis-spirochromanones as potent inhibitors of Mycobacterium tuberculosis: synthesis and biological evaluation.

Authors:  Ashok Dongamanti; Vikas Kumar Aamate; Mohan Gandhi Devulapally; Srinivas Gundu; Saikrishna Balabadra; Vijjulatha Manga; Perumal Yogeeswari; Dharmarajan Sriram; Sridhar Balasubramanian
Journal:  Mol Divers       Date:  2017-08-24       Impact factor: 2.943

2.  Rigid 3D-spiro chromanone as a crux for efficient antimicrobial agents: synthesis, biological and computational evaluation.

Authors:  F H Elghareeb; E M Kandil; M Abou-Elzahab; M Abdelmoteleb; M A Abozeid
Journal:  RSC Adv       Date:  2021-06-16       Impact factor: 4.036

3.  Synthesis of 8',11'-dihydrospiro[cyclohexane-1,2'-oxepino[2,3-h] chromen]-4'(3'H)-ones with ring closing metathesis as a key step.

Authors:  Prathima K; Ashok D; Sarasija M; Prabhakar Sripadi; Madhu Vemula; Venkata S Komarraju; Biswajit Gorai; Shyam Prakash
Journal:  RSC Adv       Date:  2018-11-16       Impact factor: 4.036

4.  Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents.

Authors:  Viswanadh Nalla; Aslam Shaikh; Sanket Bapat; Renu Vyas; M Karthikeyan; P Yogeeswari; D Sriram; M Muthukrishnan
Journal:  R Soc Open Sci       Date:  2018-04-04       Impact factor: 2.963

5.  New Chromane-Based Derivatives as Inhibitors of Mycobacterium tuberculosis Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies.

Authors:  Elena Pini; Giulio Poli; Tiziano Tuccinardi; Laurent Roberto Chiarelli; Matteo Mori; Arianna Gelain; Luca Costantino; Stefania Villa; Fiorella Meneghetti; Daniela Barlocco
Journal:  Molecules       Date:  2018-06-21       Impact factor: 4.411

Review 6.  Chromanone-A Prerogative Therapeutic Scaffold: An Overview.

Authors:  Sonia Kamboj; Randhir Singh
Journal:  Arab J Sci Eng       Date:  2021-06-30       Impact factor: 2.807
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.