Literature DB >> 23357175

Molecular monitoring of antimalarial drug resistance among Plasmodium falciparum field isolates from Odisha, India.

Sasmita Kumari Das Sutar1, Gunanidhi Dhangadamajhi, Shantanu Kumar Kar, Manoranjan Ranjit.   

Abstract

In the absence of definite marker for artemisinin (ART) resistance, molecular monitoring of its partner drug sulfadoxine pyrimethamine (SP) in artemisinin based combination therapy (ACTs) together with chloroquine (CQ) for which ART is negatively correlated, may predict the effectiveness of ACT. We analyzed 201 Plasmodium falciparum field isolates for drug resistance markers for CQ (pfcrt and pfmdr1), pyrimethamine (pfdhfr) and sulfadoxine (pfdhps). Our study reveals high prevalence and non-random association of resistant mutants (K76T and N86Y) of CQ markers (pfcrt and pfmdr1). The predominance of highly resistant pfdhfr genotypes for SP with intragenic and intergenic pair-wise linkage disequilibrium between single nucleotide polymorphisms of resistant mutants of pfdhfr (C59R and S108N) and pfdhps (S436A, A437G, K540E) warn on further inclusion of SP in ACT. These findings suggest the replacement of SP in ACT with alternative partner drug for better efficacy.
Copyright © 2013 Elsevier B.V. All rights reserved.

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Year:  2013        PMID： 23357175     DOI： 10.1016/j.actatropica.2013.01.010

Source DB:  PubMed          Journal:  Acta Trop        ISSN： 0001-706X            Impact factor:   3.112


  6 in total

1.  Monitoring artemisinin resistance in Plasmodium falciparum: comparison of parasite clearance time by microscopy and real-time PCR and evaluation of mutations in Pfatpase6 gene in Odisha state of India.

Authors:  Ruchi Gupta; Neelima Mishra; Ashwani Kumar; Roma Rana; Bina Srivastava; P K Tyagi; Anupkumar R Anvikar; Neena Valecha
Journal:  Parasitol Res       Date:  2015-06-27       Impact factor: 2.289

2.  Comparative assessment on the prevalence of mutations in the Plasmodium falciparum drug-resistant genes in two different ecotypes of Odisha state, India.

Authors:  Narayani Prasad Kar; Kshipra Chauhan; Nutan Nanda; Ashwani Kumar; Jane M Carlton; Aparup Das
Journal:  Infect Genet Evol       Date:  2016-03-15       Impact factor: 3.342

3.  Climate drivers on malaria transmission in Arunachal Pradesh, India.

Authors:  Suryanaryana Murty Upadhyayula; Srinivasa Rao Mutheneni; Sumana Chenna; Vaideesh Parasaram; Madhusudhan Rao Kadiri
Journal:  PLoS One       Date:  2015-03-24       Impact factor: 3.240

4.  Polymorphism in drug resistance genes dihydrofolate reductase and dihydropteroate synthase in Plasmodium falciparum in some states of India.

Authors:  Divya Sharma; Manila Lather; Prashant K Mallick; Tridibes Adak; Amita S Dang; Neena Valecha; Om P Singh
Journal:  Parasit Vectors       Date:  2015-09-17       Impact factor: 3.876

5.  Characterization of drug resistance associated genetic polymorphisms among Plasmodium falciparum field isolates in Ujjain, Madhya Pradesh, India.

Authors:  Ashish Pathak; Andreas Mårtensson; Sudhir Gawariker; Jagdish Mandliya; Ashish Sharma; Vishal Diwan; Johan Ursing
Journal:  Malar J       Date:  2014-05-15       Impact factor: 2.979

6.  Prevalence of mutations linked to antimalarial resistance in Plasmodium falciparum from Chhattisgarh, Central India: A malaria elimination point of view.

Authors:  Priyanka Patel; Praveen K Bharti; Devendra Bansal; Nazia A Ali; Rajive K Raman; Pradyumna K Mohapatra; Rakesh Sehgal; Jagadish Mahanta; Ali A Sultan; Neeru Singh
Journal:  Sci Rep       Date:  2017-11-30       Impact factor: 4.379
  6 in total

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