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Literature DB >> 23354680

Clues from bariatric surgery: reversing insulin resistance to heal the heart.

Khaled Imad Khalaf¹, Heinrich Taegtmeyer.

Abstract

Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectively addresses the evidence for this phenomenon in the literature and discusses potential metabolic and neurohumoral mechanisms. We propose that nutrient restriction lowers the cell's defense mechanisms for nutrient overload in insulin responsive organs.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2013 PMID： 23354680 PMCID： PMC3595325 DOI： 10.1007/s11892-013-0364-1

Source DB: PubMed Journal: Curr Diab Rep ISSN： 1534-4827 Impact factor: 4.810

52 in total

1. Heart disease and stroke statistics--2012 update: a report from the American Heart Association.

Authors: Véronique L Roger; Alan S Go; Donald M Lloyd-Jones; Emelia J Benjamin; Jarett D Berry; William B Borden; Dawn M Bravata; Shifan Dai; Earl S Ford; Caroline S Fox; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; Diane M Makuc; Gregory M Marcus; Ariane Marelli; David B Matchar; Claudia S Moy; Dariush Mozaffarian; Michael E Mussolino; Graham Nichol; Nina P Paynter; Elsayed Z Soliman; Paul D Sorlie; Nona Sotoodehnia; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner
Journal: Circulation Date: 2011-12-15 Impact factor: 29.690

Review 2. The metabolic syndrome: time to get off the merry-go-round?

Authors: G M Reaven
Journal: J Intern Med Date: 2010-12-03 Impact factor: 8.989

Review 3. Bariatric surgery to unload the stressed heart: a metabolic hypothesis.

Authors: Mohamed F Algahim; Shiraj Sen; Heinrich Taegtmeyer
Journal: Am J Physiol Heart Circ Physiol Date: 2012-02-03 Impact factor: 4.733

Review 4. Clinical practice. Diagnosis of diabetes.

Authors: Silvio E Inzucchi
Journal: N Engl J Med Date: 2012-08-09 Impact factor: 91.245

5. The influence of body composition, fat distribution, and sustained weight loss on left ventricular mass and geometry in obesity.

Authors: Dimitris Kardassis; Odd Bech-Hanssen; Marie Schönander; Lars Sjöström; Kristjan Karason
Journal: Obesity (Silver Spring) Date: 2011-05-12 Impact factor: 5.002

Review 6. After avandia: the use of antidiabetic drugs in patients with heart failure.

Authors: Khaled I Khalaf; Heinrich Taegtmeyer
Journal: Tex Heart Inst J Date: 2012

Review 7. Long-term outcomes after bariatric surgery: fifteen-year follow-up of adjustable gastric banding and a systematic review of the bariatric surgical literature.

Authors: Paul E O'Brien; Leah MacDonald; Margaret Anderson; Leah Brennan; Wendy A Brown
Journal: Ann Surg Date: 2013-01 Impact factor: 12.969

8. Effects of bariatric surgery on cardiac ectopic fat: lesser decrease in epicardial fat compared to visceral fat loss and no change in myocardial triglyceride content.

Authors: Bénédicte Gaborit; Alexis Jacquier; Frank Kober; Ines Abdesselam; Thomas Cuisset; Sandrine Boullu-Ciocca; Olivier Emungania; Marie-Christine Alessi; Karine Clément; Monique Bernard; Anne Dutour
Journal: J Am Coll Cardiol Date: 2012-08-29 Impact factor: 24.094

9. Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects.

Authors: Lena M S Carlsson; Markku Peltonen; Sofie Ahlin; Åsa Anveden; Claude Bouchard; Björn Carlsson; Peter Jacobson; Hans Lönroth; Cristina Maglio; Ingmar Näslund; Carlo Pirazzi; Stefano Romeo; Kajsa Sjöholm; Elisabeth Sjöström; Hans Wedel; Per-Arne Svensson; Lars Sjöström
Journal: N Engl J Med Date: 2012-08-23 Impact factor: 91.245