Literature DB >> 23354127

Diabetes, bilirubin and amputations: is there a link?

N Katsiki1, A Karagiannis, D P Mikhailidis.   

Abstract

A study by Chan et al in this issue of Diabetologia (DOI: 10.1007/s00125-012-2818-4 ) reports that low plasma bilirubin levels are associated with an increased risk of amputation in patients with type 2 diabetes mellitus participating in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. These findings raise the interesting and clinically relevant hypothesis that bilirubin protects against risk of amputation in patients with type 2 diabetes. This commentary considers some of the limitations associated with research aiming to define any link between circulating bilirubin levels and vascular disease. Numerous confounding factors (several of which may be present in patients with type 2 diabetes) may explain why the literature regarding this potentially protective role of bilirubin remains controversial.

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Year:  2013        PMID： 23354127     DOI： 10.1007/s00125-013-2840-1

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  18 in total

1.  Serum bilirubin and cardiovascular risk factors in a Chinese population.

Authors:  G T Ko; J C Chan; J Woo; E Lau; V T Yeung; C C Chow; J K Li; W Y So; C S Cockram
Journal:  J Cardiovasc Risk       Date:  1996-10

2.  Association of lower total bilirubin level with statin usage: the United States National Health and Nutrition Examination Survey 1999-2008.

Authors:  Kwok Leung Ong; Ben J Wu; Bernard M Y Cheung; Philip J Barter; Kerry-Anne Rye
Journal:  Atherosclerosis       Date:  2011-07-23       Impact factor: 5.162

3.  High serum bilirubin levels and diabetic retinopathy: the Hisayama Study.

Authors:  Miho Yasuda; Yutaka Kiyohara; Jie Jin Wang; Satoshi Arakawa; Koji Yonemoto; Yasufumi Doi; Toshiharu Ninomiya; Tatsuro Ishibashi
Journal:  Ophthalmology       Date:  2011-05-20       Impact factor: 12.079

4.  Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis.

Authors:  Vasilios G Athyros; Konstantinos Tziomalos; Thomas D Gossios; Theodora Griva; Panagiotis Anagnostis; Konstantinos Kargiotis; Efstathios D Pagourelias; Eleni Theocharidou; Asterios Karagiannis; Dimitri P Mikhailidis
Journal:  Lancet       Date:  2010-11-23       Impact factor: 79.321

5.  Effect of hypertension and its treatment on lipid, lipoprotein(a), fibrinogen, and bilirubin levels in patients referred for dyslipidemia.

Authors:  J A Papadakis; E S Ganotakis; I A Jagroop; D P Mikhailidis; A F Winder
Journal:  Am J Hypertens       Date:  1999-07       Impact factor: 2.689

6.  High serum bilirubin is associated with the reduced risk of diabetes mellitus and diabetic nephropathy.

Authors:  Seung Seok Han; Ki Young Na; Dong-Wan Chae; Yon Su Kim; Suhnggwon Kim; Ho Jun Chin
Journal:  Tohoku J Exp Med       Date:  2010-06       Impact factor: 1.848

7.  Plasma total bilirubin levels predict amputation events in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.

Authors:  K H Chan; R L O'Connell; D R Sullivan; L S Hoffmann; K Rajamani; M Whiting; M W Donoghoe; M Vanhala; A Hamer; B Yu; R Stocker; M K C Ng; A C Keech
Journal:  Diabetologia       Date:  2013-01-17       Impact factor: 10.122

8.  Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women.

Authors:  Keizo Ohnaka; Suminori Kono; Toyoshi Inoguchi; Guang Yin; Makiko Morita; Masahiro Adachi; Hisaya Kawate; Ryoichi Takayanagi
Journal:  Diabetes Res Clin Pract       Date:  2010-01-18       Impact factor: 5.602

9.  A cohort study of serum bilirubin levels and incident non-alcoholic fatty liver disease in middle aged Korean workers.

Authors:  Yoosoo Chang; Seungho Ryu; Yiyi Zhang; Hee Jung Son; Jang-Young Kim; Juhee Cho; Eliseo Guallar
Journal:  PLoS One       Date:  2012-05-15       Impact factor: 3.240

10.  Association between total bilirubin and hemoglobin A1c in Korean type 2 diabetic patients.

Authors:  Seong-Woo Choi; Young-Hoon Lee; Sun-Seog Kweon; Hye-Rim Song; Hye-Ran Ahn; Jung-Ae Rhee; Jin-Su Choi; Min-Ho Shin
Journal:  J Korean Med Sci       Date:  2012-10-02       Impact factor: 2.153
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  3 in total

1.  Low-normal free thyroxine confers decreased serum bilirubin in type 2 diabetes mellitus.

Authors:  Petronella E Deetman; Arjan J Kwakernaak; Stephan J L Bakker; Robin P F Dullaart
Journal:  Thyroid       Date:  2013-09-04       Impact factor: 6.568

2.  High sensitive C-reactive protein and serum amyloid A are inversely related to serum bilirubin: effect-modification by metabolic syndrome.

Authors:  Petronella E Deetman; Stephan J L Bakker; Robin P F Dullaart
Journal:  Cardiovasc Diabetol       Date:  2013-11-09       Impact factor: 9.951

3.  The relationship of the anti-oxidant bilirubin with free thyroxine is modified by insulin resistance in euthyroid subjects.

Authors:  Petronella E Deetman; Stephan J L Bakker; Arjan J Kwakernaak; Gerjan Navis; Robin P F Dullaart
Journal:  PLoS One       Date:  2014-03-03       Impact factor: 3.240
  3 in total

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