AIM: The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA(1c), and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n=12,400). METHODS: Analysis of covariance and logistic regression analysis were used to estimate geometric means of hs-CRP and HbA(1c) and odds ratios of prevalent diabetes according to bilirubin concentrations, respectively, with statistical adjustment for behavioral factors and liver enzymes. RESULTS: Geometric means of hs-CRP and HbA(1c) were progressively lower with increasing concentrations of serum bilirubin in men and women each. An inverse association between serum bilirubin and HbA(1c) was slightly attenuated after adjustment for hs-CRP, but still remained highly significant (trend P=0.0004 in men and trend P=10(-5) in women). Multivariate-adjusted odds ratios of prevalent diabetes for the lowest to highest quintiles of serum total bilirubin were 1.00, 1.00, 0.73, 0.80, and 0.73 (trend P=0.002), without adjustment for hs-CRP, and 1.00, 1.04, 0.76, 0.86, and 0.79 (trend P=0.01), with adjustment for hs-CRP. CONCLUSIONS: Higher concentrations of serum bilirubin probably confer protection against the development of type 2 diabetes.
AIM: The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA(1c), and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n=12,400). METHODS: Analysis of covariance and logistic regression analysis were used to estimate geometric means of hs-CRP and HbA(1c) and odds ratios of prevalent diabetes according to bilirubin concentrations, respectively, with statistical adjustment for behavioral factors and liver enzymes. RESULTS: Geometric means of hs-CRP and HbA(1c) were progressively lower with increasing concentrations of serum bilirubin in men and women each. An inverse association between serum bilirubin and HbA(1c) was slightly attenuated after adjustment for hs-CRP, but still remained highly significant (trend P=0.0004 in men and trend P=10(-5) in women). Multivariate-adjusted odds ratios of prevalent diabetes for the lowest to highest quintiles of serum total bilirubin were 1.00, 1.00, 0.73, 0.80, and 0.73 (trend P=0.002), without adjustment for hs-CRP, and 1.00, 1.04, 0.76, 0.86, and 0.79 (trend P=0.01), with adjustment for hs-CRP. CONCLUSIONS: Higher concentrations of serum bilirubin probably confer protection against the development of type 2 diabetes.
Authors: Kunihiro Matsushita; Emma K Williams; Morgana L Mongraw-Chaffin; Josef Coresh; Maria Ines Schmidt; Frederick L Brancati; Ron C Hoogeveen; Christie M Ballantyne; J Hunter Young Journal: Am J Epidemiol Date: 2013-06-30 Impact factor: 4.897
Authors: N Ikeda; T Inoguchi; N Sonoda; M Fujii; R Takei; E Hirata; H Yokomizo; J Zheng; Y Maeda; K Kobayashi; R Takayanagi Journal: Diabetologia Date: 2011-05-26 Impact factor: 10.122
Authors: K H Chan; R L O'Connell; D R Sullivan; L S Hoffmann; K Rajamani; M Whiting; M W Donoghoe; M Vanhala; A Hamer; B Yu; R Stocker; M K C Ng; A C Keech Journal: Diabetologia Date: 2013-01-17 Impact factor: 10.122
Authors: Huansheng Dong; Hu Huang; Xinxu Yun; Do-sung Kim; Yinan Yue; Hongju Wu; Alton Sutter; Kenneth D Chavin; Leo E Otterbein; David B Adams; Young-Bum Kim; Hongjun Wang Journal: Endocrinology Date: 2014-01-01 Impact factor: 4.736