OBJECTIVE: To assess the 10-year incidence of retinal vein occlusions (RVOs) and associated factors in adult Chinese subjects. DESIGN: Population-based, longitudinal study. PARTICIPANTS: The Beijing Eye Study, which included 4439 subjects (age: 40+ years) in 2001, was repeated in 2011 with 2695 subjects participating (66.4% of the survivors). METHODS: The study participants underwent a detailed ophthalmic examination. Fundus photographs were examined for the new development of RVOs, differentiated into branch RVOs (BRVOs) and central RVOs (CRVOs). MAIN OUTCOME MEASURES: Incidence of RVOs. RESULTS: Incident RVOs were detected in 51 eyes (49 subjects) with an incidence of 1.9 ± 0.1 per 100 persons and 1.0 ± 0.1 per 100 eyes. Incidence of BRVO was 1.6 ± 0.1 per 100 subjects (43 subjects [88% of patients with RVO]; 44 eyes), and incidence of CRVO was 0.3 ± 0.1 per 100 persons. Of 61 patients with an RVO in 2001 and 25 subjects reexamined in 2011, at least 4 subjects (7%) developed a second RVO. Incident BRVOs were located more often in the superior temporal quadrant and inferior temporal quadrant (32% and 34%, respectively) than in the superior nasal quadrant and inferior nasal quadrant (21% and 14%, respectively). In 35 eyes (80% of the BRVO eyes), the BRVO was located at an arteriovenous crossing. At the crossing sites, arterioles were found superficial to venules in 28 eyes (64% of the BRVO eyes). Macular edema was detected in 18 (37%) of all RVO eyes, including 13 (30%) of BRVO eyes. In multivariate logistic analysis, incident RVOs were associated with higher systolic blood pressure (P = 0.01; odds ratio [OR], 1.04), hypertension (P = 0.03; OR, 4.62), lower cognitive function score (P = 0.007; OR, 0.88), blood concentration of cholesterol ≥ 5.72 mmol/L (P = 0.007; OR, 3.29), and status after cerebral infarction/hemorrhage (P = 0.02; OR, 1.19). Incident RVOs were not significantly related to the intake of aspirin (P=0.37). CONCLUSIONS: The 10-year incidence of RVOs in Greater Beijing (1.9 ± 0.1 per 100 persons) was similar to that in other studies on Caucasian populations. The 10-year incidence of RVOs was related to the known risk factors of arterial hypertension, hypercholesterolemia, and status after cerebral infarction/hemorrhage, as well as with a lower cognitive function score. Incident BRVO was approximately 6 times more frequent than incident CRVO. Macular edema was detected in approximately 30% of BRVO eyes.
OBJECTIVE: To assess the 10-year incidence of retinal vein occlusions (RVOs) and associated factors in adult Chinese subjects. DESIGN: Population-based, longitudinal study. PARTICIPANTS: The Beijing Eye Study, which included 4439 subjects (age: 40+ years) in 2001, was repeated in 2011 with 2695 subjects participating (66.4% of the survivors). METHODS: The study participants underwent a detailed ophthalmic examination. Fundus photographs were examined for the new development of RVOs, differentiated into branch RVOs (BRVOs) and central RVOs (CRVOs). MAIN OUTCOME MEASURES: Incidence of RVOs. RESULTS: Incident RVOs were detected in 51 eyes (49 subjects) with an incidence of 1.9 ± 0.1 per 100 persons and 1.0 ± 0.1 per 100 eyes. Incidence of BRVO was 1.6 ± 0.1 per 100 subjects (43 subjects [88% of patients with RVO]; 44 eyes), and incidence of CRVO was 0.3 ± 0.1 per 100 persons. Of 61 patients with an RVO in 2001 and 25 subjects reexamined in 2011, at least 4 subjects (7%) developed a second RVO. Incident BRVOs were located more often in the superior temporal quadrant and inferior temporal quadrant (32% and 34%, respectively) than in the superior nasal quadrant and inferior nasal quadrant (21% and 14%, respectively). In 35 eyes (80% of the BRVO eyes), the BRVO was located at an arteriovenous crossing. At the crossing sites, arterioles were found superficial to venules in 28 eyes (64% of the BRVO eyes). Macular edema was detected in 18 (37%) of all RVO eyes, including 13 (30%) of BRVO eyes. In multivariate logistic analysis, incident RVOs were associated with higher systolic blood pressure (P = 0.01; odds ratio [OR], 1.04), hypertension (P = 0.03; OR, 4.62), lower cognitive function score (P = 0.007; OR, 0.88), blood concentration of cholesterol ≥ 5.72 mmol/L (P = 0.007; OR, 3.29), and status after cerebral infarction/hemorrhage (P = 0.02; OR, 1.19). Incident RVOs were not significantly related to the intake of aspirin (P=0.37). CONCLUSIONS: The 10-year incidence of RVOs in Greater Beijing (1.9 ± 0.1 per 100 persons) was similar to that in other studies on Caucasian populations. The 10-year incidence of RVOs was related to the known risk factors of arterial hypertension, hypercholesterolemia, and status after cerebral infarction/hemorrhage, as well as with a lower cognitive function score. Incident BRVO was approximately 6 times more frequent than incident CRVO. Macular edema was detected in approximately 30% of BRVO eyes.
Authors: Alexander Pinhas; Michael Dubow; Nishit Shah; Eric Cheang; Chun L Liu; Moataz Razeen; Alexander Gan; Rishard Weitz; Yusufu N Sulai; Toco Y Chui; Alfredo Dubra; Richard B Rosen Journal: Retina Date: 2015-10 Impact factor: 4.256
Authors: Yoshihiro Inamoto; Igor Petriček; Linda Burns; Saurabh Chhabra; Zachariah DeFilipp; Peiman Hematti; Alicia Rovó; Raquel Schears; Ami Shah; Vaibhav Agrawal; Aisha Ahmed; Ibrahim Ahmed; Asim Ali; Mahmoud Aljurf; Hassan Alkhateeb; Amer Beitinjaneh; Neel Bhatt; Dave Buchbinder; Michael Byrne; Natalie Callander; Kristina Fahnehjelm; Nosha Farhadfar; Robert Peter Gale; Siddhartha Ganguly; Shahrukh Hashmi; Gerhard C Hildebrandt; Erich Horn; Ann Jakubowski; Rammurti T Kamble; Jason Law; Catherine Lee; Sunita Nathan; Olaf Penack; Ravi Pingali; Pinki Prasad; Drazen Pulanic; Seth Rotz; Aditya Shreenivas; Amir Steinberg; Khalid Tabbara; André Tichelli; Baldeep Wirk; Jean Yared; Grzegorz W Basak; Minoo Battiwalla; Rafael Duarte; Bipin N Savani; Mary E D Flowers; Bronwen E Shaw; Nuria Valdés-Sanz Journal: Biol Blood Marrow Transplant Date: 2018-12-03 Impact factor: 5.742