Literature DB >> 23351864

Fresh osteochondral allograft is a suitable alternative for wide cartilage defect in the knee.

A Giorgini1, D Donati, L Cevolani, T Frisoni, F Zambianchi, F Catani.   

Abstract

INTRODUCTION: There are several surgical options to restore a wide osteochondral defect in the knee. Fresh osteochondral allografts are usually considered a poor alternative due to their difficulties in surgical application. The aim of this work is first to present our experience including the surgical technique and the functional results of patients receiving fresh osteochondral allograft to restore major knee lesions, then, to compare our results with other results presented in literature.
METHODS: Between 2006 and 2011, we treated 11 patients with osteochondral lesion of the knee (Outerbridge IV°). The average lesion size was 10.3 cm(2) (range 3-20 cm(2)). The average age was 34 years (range 18-66). Patients were followed from 12 to 55 months (average of 26.5) through clinical examination, X-ray film and MRI every 3 months for the first year, then every 6 months.
RESULTS: The treatment was successful in 10 patients showing pain regression and mean IKDC subjective score improvements from 27.3 to 58.7. The IKDC objective score also improved of at least one class for each patient except the who failed. The radiographs show good osteointegration in all cases but one.
CONCLUSIONS: Fresh allograft is an effective therapy for osteochondral defects repair because it allows functional recovery in a considerable number of patients. This technique obtains better results in lesion smaller than 8 cm(2). However larger lesion show good results. LEVEL OF EVIDENCE: Therapeutic study, Level IV.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID: 23351864     DOI: 10.1016/S0020-1383(13)70005-6

Source DB:  PubMed          Journal:  Injury        ISSN: 0020-1383            Impact factor:   2.586


  6 in total

1.  Effects of sequentially released BMP-2 and BMP-7 from PELA microcapsule-based scaffolds on the bone regeneration.

Authors:  Xialin Li; Weihong Yi; Anmin Jin; Yang Duan; Shaoxiong Min
Journal:  Am J Transl Res       Date:  2015-08-15       Impact factor: 4.060

Review 2.  Treatment for cartilage injuries of the knee with a new treatment algorithm.

Authors:  Ahmet Ozmeriç; Kadir Bahadır Alemdaroğlu; Nevres Hürriyet Aydoğan
Journal:  World J Orthop       Date:  2014-11-18

3.  Bipolar Osteochondral Allograft Transplantation of the Patella and Trochlea.

Authors:  Raffy Mirzayan; Michael D Charles; Michael Batech; Brian D Suh; David DeWitt
Journal:  Cartilage       Date:  2018-09-03       Impact factor: 4.634

4.  Assessment of Outcomes After Multisurface Osteochondral Allograft Transplantations in the Knee.

Authors:  James L Cook; Kylee Rucinski; Cory Crecelius; Blake Fenkell; James P Stannard
Journal:  Orthop J Sports Med       Date:  2022-06-14

Review 5.  Rehabilitation and Return-to-Play Criteria After Fresh Osteochondral Allograft Transplantation: A Systematic Review.

Authors:  Michael Stark; Somnath Rao; Brendan Gleason; Robert A Jack; Bradford Tucker; Sommer Hammoud; Kevin B Freedman
Journal:  Orthop J Sports Med       Date:  2021-07-27

Review 6.  Osteochondral Allografts in Knee Surgery: Narrative Review of Evidence to Date.

Authors:  Wilson C Lai; Hunter L Bohlen; Nathan P Fackler; Dean Wang
Journal:  Orthop Res Rev       Date:  2022-08-11
  6 in total

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