Literature DB >> 2335047

Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction.

M Weiss1.   

Abstract

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Year:  1990        PMID： 2335047     DOI： 10.2165/00003088-199018050-00006

Source DB:  PubMed          Journal:  Clin Pharmacokinet        ISSN： 0312-5963            Impact factor:   6.447


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  11 in total

1.  Pharmacokinetics of ketanserin and its metabolite ketanserin-ol in man after intravenous, intramuscular and oral administration.

Authors:  J Heykants; A Van Peer; R Woestenborghs; S Gould; J Mills
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

2.  Metabolite residence time: influence of the first-pass effect.

Authors:  M Weiss
Journal:  Br J Clin Pharmacol       Date:  1986-07       Impact factor: 4.335

3.  A general model of metabolite kinetics following intravenous and oral administration of the parent drug.

Authors:  M Weiss
Journal:  Biopharm Drug Dispos       Date:  1988 Mar-Apr       Impact factor: 1.627

Review 4.  A review of metabolite kinetics.

Authors:  K S Pang
Journal:  J Pharmacokinet Biopharm       Date:  1985-12

5.  Studies of the different metabolic pathways of antipyrine in man. Oral versus i.v. administration and the influence of urinary collection time.

Authors:  M Danhof; A van Zuilen; J K Boeijinga; D D Breimer
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

6.  Pharmacokinetics of diphenhydramine and a demethylated metabolite following intravenous and oral administration.

Authors:  G T Blyden; D J Greenblatt; J M Scavone; R I Shader
Journal:  J Clin Pharmacol       Date:  1986 Sep-Oct       Impact factor: 3.126

7.  Influence of dose and route of administration on disposition of metronidazole and its major metabolites.

Authors:  S Loft; M Døssing; H E Poulsen; J Sonne; K L Olesen; K Simonsen; P B Andreasen
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

8.  Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability.

Authors:  H J Gilfrich; G Kremer; W Möhrke; E Mutschler; K D Völger
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

9.  Pharmacokinetics of lidocaine and its deethylated metabolite: dose and time dependency studies in man.

Authors:  P N Bennett; L J Aarons; M R Bending; J A Steiner; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1982-06

10.  Disposition of nomifensine after acute and prolonged dosing.

Authors:  R L Lindberg; E K Syvälahti; K K Pihlajamäki
Journal:  Clin Pharmacol Ther       Date:  1986-04       Impact factor: 6.875
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  6 in total

1.  The relevance of residence time theory to pharmacokinetics.

Authors:  M Weiss
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

2.  Physiological modeling to understand the impact of enzymes and transporters on drug and metabolite data and bioavailability estimates.

Authors:  Huadong Sun; K Sandy Pang
Journal:  Pharm Res       Date:  2010-04-06       Impact factor: 4.200

3.  Evaluation of hepatic function using the pharmacokinetics of a therapeutically administered drug. Application to the immunosuppressant cyclosporin.

Authors:  W Weber; M Looby; J Brockmöller
Journal:  Clin Pharmacokinet       Date:  1992-07       Impact factor: 6.447

Review 4.  Assessment of liver metabolic function. Clinical implications.

Authors:  J Brockmöller; I Roots
Journal:  Clin Pharmacokinet       Date:  1994-09       Impact factor: 6.447

Review 5.  Individual variation in first-pass metabolism.

Authors:  Y K Tam
Journal:  Clin Pharmacokinet       Date:  1993-10       Impact factor: 6.447

6.  High bioavailability of bisphenol A from sublingual exposure.

Authors:  Véronique Gayrard; Marlène Z Lacroix; Séverine H Collet; Catherine Viguié; Alain Bousquet-Melou; Pierre-Louis Toutain; Nicole Picard-Hagen
Journal:  Environ Health Perspect       Date:  2013-06-12       Impact factor: 9.031
  6 in total

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