[Anti-HIV nucleoside drugs: retrospective view at future].

This review provides data on the design of antiretroviral drugs based on nucleoside analogs. About 30 drugs were approved for the treatment of HIV-infected patients over 25 years. Seven nucleoside drugs are inhibitors of HIV reverse transcriptase and clinically used in combination with inhibitors of other viral enzymes, integrase and protease, and non-nucleoside inhibitors of reverse transcriptase. Toxicity of nucleoside drugs and approaches to obtaining of safe anti-HIV drugs are discussed. The results of developing of domestic anti-HIV drugs are presented. The future prospects of anti-HIV investigations are considered.