Literature DB >> 23349565

Configuration and Performance of a Mobile (129)Xe Polarizer.

Sergey E Korchak1, Wolfgang Kilian, Lorenz Mitschang.   

Abstract

A stand-alone, self-contained and transportable system for the polarization of (129)Xe by spin exchange optical pumping with Rb is described. This mobile polarizer may be operated in batch or continuous flow modes with medium amounts of hyperpolarized (129)Xe for spectroscopic or small animal applications. A key element is an online nuclear magnetic resonance module which facilitates continuous monitoring of polarization generation in the pumping cell as well as the calculation of the absolute (129)Xe polarization. The performance of the polarizer with respect to the crucial parameters temperature, xenon and nitrogen partial pressures, and the total gas flow is discussed. In batch mode the highest (129)Xe polarization of P(Xe) = 40 % was achieved using 0.1 mbar xenon partial pressure. For a xenon flow of 6.5 and 26 mln/min, P(Xe) = 25 % and P(Xe) = 13 % were reached, respectively. The mobile polarizer may be a practical and efficient means to make the applicability of hyperpolarized (129)Xe more widespread.

Entities:  

Year:  2012        PMID: 23349565      PMCID: PMC3549238          DOI: 10.1007/s00723-012-0425-7

Source DB:  PubMed          Journal:  Appl Magn Reson        ISSN: 0937-9347            Impact factor:   0.831


  21 in total

1.  Energy transport in high-density spin-exchange optical pumping cells.

Authors:  D K Walter; W M Griffith; W Happer
Journal:  Phys Rev Lett       Date:  2001-04-09       Impact factor: 9.161

2.  High capacity production of >65% spin polarized xenon-129 for NMR spectroscopy and imaging.

Authors:  Anthony L Zook; Bhavin B Adhyaru; Clifford R Bowers
Journal:  J Magn Reson       Date:  2002-12       Impact factor: 2.229

3.  Dynamic NMR spectroscopy of hyperpolarized (129)Xe in human brain analyzed by an uptake model.

Authors:  Wolfgang Kilian; Frank Seifert; Herbert Rinneberg
Journal:  Magn Reson Med       Date:  2004-04       Impact factor: 4.668

Review 4.  Hyperpolarized xenon in NMR and MRI.

Authors:  Ana-Maria Oros; N Jon Shah
Journal:  Phys Med Biol       Date:  2004-10-21       Impact factor: 3.609

Review 5.  Advances in magnetic resonance imaging of lung physiology.

Authors:  Susan R Hopkins; David L Levin; Kiarash Emami; Stephen Kadlecek; Jiangsheng Yu; Masaru Ishii; Rahim R Rizi
Journal:  J Appl Physiol (1985)       Date:  2006-12-07

6.  Hyperpolarized (129)Xe MRI: a viable functional lung imaging modality?

Authors:  Samuel Patz; F William Hersman; Iga Muradian; Mirko I Hrovat; Iulian C Ruset; Stephen Ketel; Francine Jacobson; George P Topulos; Hiroto Hatabu; James P Butler
Journal:  Eur J Radiol       Date:  2007-09-24       Impact factor: 3.528

7.  NMR calibration of optical measurement of nuclear polarization in 3He.

Authors: 
Journal:  Phys Rev A       Date:  1993-01       Impact factor: 3.140

8.  Measurement of rubidium and xenon absolute polarization at high temperatures as a means of improved production of hyperpolarized (129)Xe.

Authors:  N J Shah; T Unlü; H P Wegener; H Halling; K Zilles; S Appelt
Journal:  NMR Biomed       Date:  2000-06       Impact factor: 4.044

Review 9.  Functionalized 129Xe contrast agents for magnetic resonance imaging.

Authors:  Olena Taratula; Ivan J Dmochowski
Journal:  Curr Opin Chem Biol       Date:  2009-11-13       Impact factor: 8.822

10.  Crystallographic observation of 'induced fit' in a cryptophane host-guest model system.

Authors:  Olena Taratula; P Aru Hill; Najat S Khan; Patrick J Carroll; Ivan J Dmochowski
Journal:  Nat Commun       Date:  2010-12-21       Impact factor: 14.919

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  11 in total

Review 1.  3He diffusion MRI in human lungs.

Authors:  Jason C Woods; Mark S Conradi
Journal:  J Magn Reson       Date:  2018-04-26       Impact factor: 2.229

2.  Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.

Authors:  Mu He; Scott H Robertson; S Sivaram Kaushik; Matthew S Freeman; Rohan S Virgincar; John Davies; Jane Stiles; William M Foster; H Page McAdams; Bastiaan Driehuys
Journal:  Magn Reson Imaging       Date:  2015-04-30       Impact factor: 2.546

3.  A 3D-printed high power nuclear spin polarizer.

Authors:  Panayiotis Nikolaou; Aaron M Coffey; Laura L Walkup; Brogan M Gust; Cristen D LaPierre; Edward Koehnemann; Michael J Barlow; Matthew S Rosen; Boyd M Goodson; Eduard Y Chekmenev
Journal:  J Am Chem Soc       Date:  2014-01-21       Impact factor: 15.419

4.  XeNA: an automated 'open-source' (129)Xe hyperpolarizer for clinical use.

Authors:  Panayiotis Nikolaou; Aaron M Coffey; Laura L Walkup; Brogan M Gust; Nicholas Whiting; Hayley Newton; Iga Muradyan; Mikayel Dabaghyan; Kaili Ranta; Gregory D Moroz; Matthew S Rosen; Samuel Patz; Michael J Barlow; Eduard Y Chekmenev; Boyd M Goodson
Journal:  Magn Reson Imaging       Date:  2014-02-10       Impact factor: 2.546

5.  Feasibility, tolerability and safety of pediatric hyperpolarized 129Xe magnetic resonance imaging in healthy volunteers and children with cystic fibrosis.

Authors:  Laura L Walkup; Robert P Thomen; Teckla G Akinyi; Erin Watters; Kai Ruppert; John P Clancy; Jason C Woods; Zackary I Cleveland
Journal:  Pediatr Radiol       Date:  2016-08-05

6.  Characterizing and modeling the efficiency limits in large-scale production of hyperpolarized 129Xe.

Authors:  M S Freeman; K Emami; B Driehuys
Journal:  Phys Rev A       Date:  2014-08-06       Impact factor: 3.140

7.  Depolarization of nuclear spin polarized 129Xe gas by dark rubidium during spin-exchange optical pumping.

Authors:  M A Antonacci; Alex Burant; Wolfgang Wagner; Rosa T Branca
Journal:  J Magn Reson       Date:  2017-04-22       Impact factor: 2.229

Review 8.  Enabling Clinical Technologies for Hyperpolarized 129 Xenon Magnetic Resonance Imaging and Spectroscopy.

Authors:  Alixander S Khan; Rebecca L Harvey; Jonathan R Birchall; Robert K Irwin; Panayiotis Nikolaou; Geoffry Schrank; Kiarash Emami; Andrew Dummer; Michael J Barlow; Boyd M Goodson; Eduard Y Chekmenev
Journal:  Angew Chem Int Ed Engl       Date:  2021-06-09       Impact factor: 16.823

9.  Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation.

Authors:  Hirohiko Imai; Hironobu Yoshimura; Atsuomi Kimura; Hideaki Fujiwara
Journal:  Sci Rep       Date:  2017-08-04       Impact factor: 4.379

10.  Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications.

Authors:  Theodore Hughes-Riley; Joseph S Six; David M L Lilburn; Karl F Stupic; Alan C Dorkes; Dominick E Shaw; Galina E Pavlovskaya; Thomas Meersmann
Journal:  J Magn Reson       Date:  2013-09-21       Impact factor: 2.229

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