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Literature DB >> 23348381

Metastasis suppressor genes.

Abstract

Metastasis is a major cause of cancer mortality. Metastasis is a complex process that requires the regulation of both metastasis-promoting and metastasis suppressor genes. The discovery of metastasis suppressor genes contributes significantly to our understanding of metastasis mechanisms and provides prognostic markers and therapeutic targets in clinical cancer management. In this review, we summarize the methods that have been used to identify metastasis suppressors and the potential clinical impact of these genes.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2013 PMID： 23348381 PMCID： PMC3910084 DOI： 10.14670/HH-28.285

Source DB: PubMed Journal: Histol Histopathol ISSN： 0213-3911 Impact factor: 2.303

111 in total

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Authors: Lin He; Gregory J Hannon
Journal: Nat Rev Genet Date: 2004-07 Impact factor: 53.242

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Journal: Cell Date: 1990-11-30 Impact factor: 41.582

7. The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer.

Authors: Taku Takeuchi; Michiyoshi Hisanaga; Mitsuo Nagao; Naoya Ikeda; Hisao Fujii; Fumikazu Koyama; Tomohide Mukogawa; Hiroshi Matsumoto; Shunya Kondo; Chiaki Takahashi; Makoto Noda; Yoshiyuki Nakajima
Journal: Clin Cancer Res Date: 2004-08-15 Impact factor: 12.531

8. Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer.

Authors: Kazumasa Takenaka; Shinya Ishikawa; Yozo Kawano; Kazuhiro Yanagihara; Ryo Miyahara; Yosuke Otake; Yoko Morioka; Chiaki Takahashi; Makoto Noda; Hiromi Wada; Fumihiro Tanaka
Journal: Eur J Cancer Date: 2004-07 Impact factor: 9.162

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Journal: Proc Natl Acad Sci U S A Date: 1977-01 Impact factor: 11.205

10. Prognostic significance of nm23-H1 expression in oral squamous cell carcinoma.

Authors: Y-F Wang; K-C Chow; S-Y Chang; J-H Chiu; S-K Tai; W-Y Li; L-S Wang
Journal: Br J Cancer Date: 2004-06-01 Impact factor: 7.640

14 in total

Review 1. Genetic insights into the morass of metastatic heterogeneity.

Authors: Kent W Hunter; Ruhul Amin; Sarah Deasy; Ngoc-Han Ha; Lalage Wakefield
Journal: Nat Rev Cancer Date: 2018-02-09 Impact factor: 60.716

2. BRMS1 Expression in Surgically Resected Lung Adenocarcinoma Predicts Future Metastases and Is Associated with a Poor Prognosis.

Authors: Peter R Bucciarelli; Kay See Tan; Neel P Chudgar; Whitney Brandt; Joseph Montecalvo; Takashi Eguchi; Yuan Liu; Rania Aly; William D Travis; Prasad S Adusumilli; David R Jones
Journal: J Thorac Oncol Date: 2017-10-31 Impact factor: 15.609

Review 3. The potential role of leptin in tumor invasion and metastasis.

Authors: Amitabha Ray; Margot P Cleary
Journal: Cytokine Growth Factor Rev Date: 2017-11-11 Impact factor: 7.638

4. MicroRNA-1246 suppresses the metastasis of breast cancer cells by targeting the DYRK1A/PGRN axis to prevent the epithelial-mesenchymal transition.

Authors: Pan Wang; Wenju Chen; Yaqiong Zhang; Qianyi Zhong; Zhaoyun Li; Yichao Wang
Journal: Mol Biol Rep Date: 2022-01-21 Impact factor: 2.316

Review 5. The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets.

Authors: Wensheng Liu; Zaklina Kovacevic; Zhihai Peng; Runsen Jin; Puxiongzhi Wang; Fei Yue; Minhua Zheng; Michael L-H Huang; Patric J Jansson; Vera Richardson; Danuta S Kalinowski; Darius J R Lane; Angelica M Merlot; Sumit Sahni; Des R Richardson
Journal: Oncotarget Date: 2015-11-03

6. An evidence-based knowledgebase of metastasis suppressors to identify key pathways relevant to cancer metastasis.

Authors: Min Zhao; Zhe Li; Hong Qu
Journal: Sci Rep Date: 2015-10-21 Impact factor: 4.379

7. A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.

Authors: H Chen; B Lorton; V Gupta; D Shechter
Journal: Oncogene Date: 2016-06-06 Impact factor: 9.867