OBJECTIVE: We examined resting state functional connectivity in the brain between key emotion regulation regions in bipolar I disorder to delineate differences in coupling from healthy subjects. METHODS: Euthymic subjects with bipolar I disorder (n = 20) and matched healthy subjects (n = 20) participated in a resting state functional magnetic resonance imaging scan. Low-frequency fluctuations in blood oxygen level-dependent (BOLD) signal were correlated in the six connections between four anatomically defined nodes: left and right amygdala and left and right ventrolateral prefrontal cortex (vlPFC). Seed-to-voxel connectivity results were probed for commonly coupled regions. Following this, an identified region was included in a mediation analysis to determine the potential of mediation. RESULTS: The bipolar I disorder group exhibited significant hyperconnectivity between right amygdala and right vlPFC relative to healthy subjects. The connectivity between these regions in the bipolar I disorder group was partially mediated by activity in the anterior cingulate cortex (ACC). CONCLUSIONS: Greater coupling between right amygdala and right vlPFC and their partial mediation by the ACC were found in bipolar I disorder subjects in remission and in the absence of a psychological task. These findings have implications for a trait-related and clinically important imaging biomarker.
OBJECTIVE: We examined resting state functional connectivity in the brain between key emotion regulation regions in bipolar I disorder to delineate differences in coupling from healthy subjects. METHODS: Euthymic subjects with bipolar I disorder (n = 20) and matched healthy subjects (n = 20) participated in a resting state functional magnetic resonance imaging scan. Low-frequency fluctuations in blood oxygen level-dependent (BOLD) signal were correlated in the six connections between four anatomically defined nodes: left and right amygdala and left and right ventrolateral prefrontal cortex (vlPFC). Seed-to-voxel connectivity results were probed for commonly coupled regions. Following this, an identified region was included in a mediation analysis to determine the potential of mediation. RESULTS: The bipolar I disorder group exhibited significant hyperconnectivity between right amygdala and right vlPFC relative to healthy subjects. The connectivity between these regions in the bipolar I disorder group was partially mediated by activity in the anterior cingulate cortex (ACC). CONCLUSIONS: Greater coupling between right amygdala and right vlPFC and their partial mediation by the ACC were found in bipolar I disorder subjects in remission and in the absence of a psychological task. These findings have implications for a trait-related and clinically important imaging biomarker.
Authors: Kevin N Ochsner; Rebecca D Ray; Jeffrey C Cooper; Elaine R Robertson; Sita Chopra; John D E Gabrieli; James J Gross Journal: Neuroimage Date: 2004-10 Impact factor: 6.556
Authors: Koene R A Van Dijk; Trey Hedden; Archana Venkataraman; Karleyton C Evans; Sara W Lazar; Randy L Buckner Journal: J Neurophysiol Date: 2009-11-04 Impact factor: 2.714
Authors: Jeffrey M Spielberg; Erik B Beall; Leslie A Hulvershorn; Murat Altinay; Harish Karne; Amit Anand Journal: Neuropsychopharmacology Date: 2016-06-30 Impact factor: 7.853
Authors: Monique Ernst; Salvatore Torrisi; Nicholas Balderston; Christian Grillon; Elizabeth A Hale Journal: Annu Rev Clin Psychol Date: 2015-01-02 Impact factor: 18.561
Authors: J Stoddard; S J Gotts; M A Brotman; S Lever; D Hsu; C Zarate; M Ernst; D S Pine; E Leibenluft Journal: Psychol Med Date: 2016-02-29 Impact factor: 7.723
Authors: Kristen K Ellard; Aishwarya G Gosai; Emily E Bernstein; Navneet Kaur; Lousia G Sylvia; Joan A Camprodon; Darin D Dougherty; Andrew A Nierenberg; Thilo Deckersbach Journal: J Affect Disord Date: 2018-06-02 Impact factor: 4.839