Murat Altinay1, Harish Karne1, Amit Anand2. 1. Center for Behavioral Health, Cleveland Clinic Foundation, United States. 2. Center for Behavioral Health, Cleveland Clinic Foundation, United States. Electronic address: ananda@ccf.org.
Abstract
BACKGROUND: This study, for the first time, investigated lithium monotherapy associated effects on amygdala- ventromedial prefrontal cortex (vMPFC) resting-state functional connectivity and correlation with clinical improvement in bipolar disorder (BP) METHODS: Thirty-six medication-free subjects - 24 BP (12 hypomanic BPM) and 12 depressed (BPD)) and 12 closely matched healthy controls (HC), were included. BP subjects were treated with lithium and scanned at baseline, after 2 weeks and 8 weeks. HC were scanned at same time points but were not treated. The effect of lithium was studied for the BP group as a whole using two way (group, time) ANOVA while regressing out effects of state. Next, correlation between changes in amygdala-vMPFC resting-state connectivity and clinical global impression (CGI) of severity and improvement scale scores for overall BP illness was calculated. An exploratory analysis was also conducted for the BPD and BPM subgroups separately. RESULTS: Group by time interaction revealed that lithium monotherapy in patients was associated with increase in amygdala-medial OFC connectivity after 8 weeks of treatment (p = 0.05 (cluster-wise corrected)) compared to repeat testing in healthy controls. Increased amygdala-vMPFC connectivity correlated with clinical improvement at week 2 and week 8 as measured with the CGI-I scale. LIMITATIONS: The results pertain to open-label treatment and do not account for non-treatment related improvement effects. Only functional connectivity was measured which does not give information regarding one regions effect on the other. CONCLUSIONS: Lithium monotherapy in BP is associated with modulation of amygdala-vMPFC connectivity which correlates with state-independent global clinical improvement.
BACKGROUND: This study, for the first time, investigated lithium monotherapy associated effects on amygdala- ventromedial prefrontal cortex (vMPFC) resting-state functional connectivity and correlation with clinical improvement in bipolar disorder (BP) METHODS: Thirty-six medication-free subjects - 24 BP (12 hypomanic BPM) and 12 depressed (BPD)) and 12 closely matched healthy controls (HC), were included. BP subjects were treated with lithium and scanned at baseline, after 2 weeks and 8 weeks. HC were scanned at same time points but were not treated. The effect of lithium was studied for the BP group as a whole using two way (group, time) ANOVA while regressing out effects of state. Next, correlation between changes in amygdala-vMPFC resting-state connectivity and clinical global impression (CGI) of severity and improvement scale scores for overall BP illness was calculated. An exploratory analysis was also conducted for the BPD and BPM subgroups separately. RESULTS: Group by time interaction revealed that lithium monotherapy in patients was associated with increase in amygdala-medial OFC connectivity after 8 weeks of treatment (p = 0.05 (cluster-wise corrected)) compared to repeat testing in healthy controls. Increased amygdala-vMPFC connectivity correlated with clinical improvement at week 2 and week 8 as measured with the CGI-I scale. LIMITATIONS: The results pertain to open-label treatment and do not account for non-treatment related improvement effects. Only functional connectivity was measured which does not give information regarding one regions effect on the other. CONCLUSIONS:Lithium monotherapy in BP is associated with modulation of amygdala-vMPFC connectivity which correlates with state-independent global clinical improvement.
Authors: Kelly Rootes-Murdy; Kara Glazer; Francis M Mondimore; Fernando S Goes; Peter P Zandi; Arnold Bakker; J Raymond DePaulo; Pamela B Mahon Journal: Psychiatry Res Neuroimaging Date: 2019-02-21 Impact factor: 2.376
Authors: Wenbin Li; Du Lei; Maxwell J Tallman; Yuan Ai; Jeffrey A Welge; Thomas J Blom; David E Fleck; Christina C Klein; Luis R Patino; Jeffrey R Strawn; Qiyong Gong; Stephen M Strakowski; John A Sweeney; Caleb M Adler; Melissa P DelBello Journal: J Am Acad Child Adolesc Psychiatry Date: 2022-01-25 Impact factor: 13.113
Authors: Thomas L Athey; Can Ceritoglu; Daniel J Tward; Kwame S Kutten; J Raymond DePaulo; Kara Glazer; Fernando S Goes; John R Kelsoe; Francis Mondimore; Caroline M Nievergelt; Kelly Rootes-Murdy; Peter P Zandi; J Tilak Ratnanather; Pamela B Mahon Journal: Front Psychiatry Date: 2021-02-16 Impact factor: 4.157
Authors: Emilio Bergamelli; Lorenzo Del Fabro; Giuseppe Delvecchio; Armando D'Agostino; Paolo Brambilla Journal: CNS Drugs Date: 2021-11-12 Impact factor: 6.497