Literature DB >> 23347249

Association of chromosome 9p21 genetic variants with risk of coronary heart disease in the East Asian population: a meta-analysis.

Liping Dong1, Haoran Wang, Dao Wen Wang, Hu Ding.   

Abstract

Our aim was to evaluate the effect of SNPs in the 9p21 locus on genetic susceptibility of coronary heart disease in the East Asian population. We searched PubMed, EMBASE and CNKI for publications relating to the association between SNPs within the 9p21 locus and coronary heart disease in the East Asian population. This meta-analysis was assessed by STATA 9.2. Twenty-one studies from 15 eligible papers composing 25,945 cases and 31,777 control subjects were included in the meta-analysis. The odds ratio (OR) and 95% confidence interval (CI) for the risk allele was 1.30 (1.25-1.35) with moderate heterogeneity. No publication bias was observed in this study. Sensitivity analysis further strengthened the validity of this association. In conclusion, SNPs within the 9p21 locus were strongly associated with the risk of coronary heart disease in the East Asian population with a similar risk OR to the Caucasian population.
© 2013 Blackwell Publishing Ltd/University College London.

Entities:  

Mesh：

Year:  2013        PMID： 23347249     DOI： 10.1111/ahg.12010

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  5 in total

Review 1.  Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.

Authors:  Emelia J Benjamin; Michael J Blaha; Stephanie E Chiuve; Mary Cushman; Sandeep R Das; Rajat Deo; Sarah D de Ferranti; James Floyd; Myriam Fornage; Cathleen Gillespie; Carmen R Isasi; Monik C Jiménez; Lori Chaffin Jordan; Suzanne E Judd; Daniel Lackland; Judith H Lichtman; Lynda Lisabeth; Simin Liu; Chris T Longenecker; Rachel H Mackey; Kunihiro Matsushita; Dariush Mozaffarian; Michael E Mussolino; Khurram Nasir; Robert W Neumar; Latha Palaniappan; Dilip K Pandey; Ravi R Thiagarajan; Mathew J Reeves; Matthew Ritchey; Carlos J Rodriguez; Gregory A Roth; Wayne D Rosamond; Comilla Sasson; Amytis Towfighi; Connie W Tsao; Melanie B Turner; Salim S Virani; Jenifer H Voeks; Joshua Z Willey; John T Wilkins; Jason Hy Wu; Heather M Alger; Sally S Wong; Paul Muntner
Journal:  Circulation       Date:  2017-01-25       Impact factor: 29.690

2.  Validated context-dependent associations of coronary heart disease risk with genotype variation in the chromosome 9p21 region: the Atherosclerosis Risk in Communities study.

Authors:  Christine M Lusk; Greg Dyson; Andrew G Clark; Christie M Ballantyne; Ruth Frikke-Schmidt; Anne Tybjærg-Hansen; Eric Boerwinkle; Charles F Sing
Journal:  Hum Genet       Date:  2014-06-03       Impact factor: 4.132

3.  Genetic variation in 9p21 is associated with fasting insulin in women but not men.

Authors:  Sara Mahdavi; David J A Jenkins; Ahmed El-Sohemy
Journal:  PLoS One       Date:  2018-08-23       Impact factor: 3.240

Review 4.  Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Authors:  Daniel John Lawson; Neil Martin Davies; Simon Haworth; Bilal Ashraf; Laurence Howe; Andrew Crawford; Gibran Hemani; George Davey Smith; Nicholas John Timpson
Journal:  Hum Genet       Date:  2019-04-27       Impact factor: 4.132

5.  Value of Chromosome 9p21 Polymorphism for Prediction of Cardiovascular Mortality in Han Chinese Without Coronary Lesions: An Observational Study.

Authors:  I-Te Lee; Kae-Woei Liang; Jun-Sing Wang; Wen-Jane Lee; Yii-der Ida Chen; Shih-Yi Lin; Wen-Lieng Lee; Wayne H-H Sheu
Journal:  Medicine (Baltimore)       Date:  2015-09       Impact factor: 1.817
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.