Literature DB >> 23345921

Homochirality in bio-organic systems and glyceraldehyde in the formose reaction.

S Toxvaerd1.   

Abstract

The article explores the possibility that the ordering of bio-organic molecules into a homochiral assembly at the origin of life was performed not in aqueous solutions of amino acids or related materials but in racemic glyceraldehyde in the "formose" reaction at high concentration and temperature. Based on physical chemical evidence and computer simulations of condensed fluids, it is argued that the isomerization kinetics of glyceraldehyde is responszible of the symmetry break and the ordering of molecules into homochiral domains.

Entities:  

Keywords:  formose reaction; homochirality; origin of life

Year:  2005        PMID: 23345921      PMCID: PMC3456342          DOI: 10.1007/s10867-005-6063-7

Source DB:  PubMed          Journal:  J Biol Phys        ISSN: 0092-0606            Impact factor:   1.365


  14 in total

1.  The possible role of volcanic aquifers in prebiologic genesis of organic compounds and RNA.

Authors:  J Washington
Journal:  Orig Life Evol Biosph       Date:  2000-02       Impact factor: 1.950

2.  Molecular dynamics simulations of isomerization kinetics in condensed fluids.

Authors:  S Toxvaerd
Journal:  Phys Rev Lett       Date:  2000-11-27       Impact factor: 9.161

3.  Serine octamer reactions: indicators of prebiotic relevance.

Authors:  Zoltan Takats; Sergio C Nanita; R Graham Cooks
Journal:  Angew Chem Int Ed Engl       Date:  2003-08-04       Impact factor: 15.336

4.  Domain catalyzed chemical reactions: a molecular dynamics simulation of isomerization kinetics.

Authors:  S Toxvaerd
Journal:  J Chem Phys       Date:  2004-04-01       Impact factor: 3.488

5.  Chemical evolution and meteorites: an update.

Authors:  Sandra Pizzarello
Journal:  Orig Life Evol Biosph       Date:  2004-02       Impact factor: 1.950

6.  The evolution of lipids.

Authors:  Y H Itoh; A Sugai; I Uda; T Itoh
Journal:  Adv Space Res       Date:  2001       Impact factor: 2.152

7.  Kinetics of racemization of amino acids as a function of pH.

Authors:  J L Bada
Journal:  J Am Chem Soc       Date:  1972-02-23       Impact factor: 15.419

8.  The sugar model: catalysis by amines and amino acid products.

Authors:  A L Weber
Journal:  Orig Life Evol Biosph       Date:  2001 Feb-Apr       Impact factor: 1.950

9.  Model for origin of monosaccharides.

Authors:  N W Gabel; C Ponnamperuma
Journal:  Nature       Date:  1967-11-04       Impact factor: 49.962

10.  Prebiotic synthesis in atmospheres containing CH4, CO, and CO2. II. Hydrogen cyanide, formaldehyde and ammonia.

Authors:  G Schlesinger; S L Miller
Journal:  J Mol Evol       Date:  1983       Impact factor: 2.395

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  6 in total

1.  The role of carbohydrates at the origin of homochirality in biosystems.

Authors:  Søren Toxvaerd
Journal:  Orig Life Evol Biosph       Date:  2013-08-31       Impact factor: 1.950

2.  Spontaneous mirror symmetry breaking in the aldol reaction and its potential relevance in prebiotic chemistry.

Authors:  Michael Mauksch; Shengwei Wei; Matthias Freund; Alexandru Zamfir; Svetlana B Tsogoeva
Journal:  Orig Life Evol Biosph       Date:  2009-11-13       Impact factor: 1.950

3.  Theory of the origin, evolution, and nature of life.

Authors:  Erik D Andrulis
Journal:  Life (Basel)       Date:  2011-12-23

4.  Magnetic circular dichroism in Archean atmosphere and asymmetric photolysis of biomolecules: enantiomeric excess of prebiotic sugar.

Authors:  A Sharma
Journal:  J Biol Phys       Date:  2020-07-02       Impact factor: 1.560

5.  Assigning the absolute configuration of single aliphatic molecules by visual inspection.

Authors:  Daniel Ebeling; Marina Šekutor; Marvin Stiefermann; Jalmar Tschakert; Jeremy E P Dahl; Robert M K Carlson; André Schirmeisen; Peter R Schreiner
Journal:  Nat Commun       Date:  2018-06-20       Impact factor: 14.919

6.  Origin of homochirality in biosystems.

Authors:  Søren Toxvaerd
Journal:  Int J Mol Sci       Date:  2009-03-18       Impact factor: 6.208

  6 in total

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