Literature DB >> 23345866

AM1 Study of N-2-Acetylaminofluorene bonded to Deoxyguanosine at the Minor Adduct Site.

M Besson1, E P Batchelor.   

Abstract

We have computed the total energy as a function of six important torsion angles of the carcinogen N-2-acetylaminofluorene (AAF) bonded to thenitrogen N2 of deoxyguanosine using the semiempirical quantum mechanical method AM1. One global minimum and one local minimum are found separated by a modest barrier. We have computed the normal-mode frequencies of the relevant torsional motions and have determined the rate of conversion betweenthe two minima.

Entities:  

Keywords:  N-2-ac; deoxyguanosine

Year:  2004        PMID： 23345866      PMCID： PMC3456492          DOI： 10.1023/B:JOBP.0000035860.68226.22

Source DB:  PubMed          Journal:  J Biol Phys        ISSN： 0092-0606            Impact factor:   1.365


  25 in total

1.  In vitro recognition of carcinogen-induced local denaturation sites native DNA by S1 endonuclease from Aspergillus oryzae.

Authors:  R P Fuchs
Journal:  Nature       Date:  1975-09-11       Impact factor: 49.962

Review 2.  MOPAC: a semiempirical molecular orbital program.

Authors:  J J Stewart
Journal:  J Comput Aided Mol Des       Date:  1990-03       Impact factor: 3.686

Review 3.  Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox Carcinogen Data Base. A report of the U.S. Environmental Protection Agency Gene-Tox Program.

Authors:  S Nesnow; M Argus; H Bergman; K Chu; C Frith; T Helmes; R McGaughy; V Ray; T J Slaga; R Tennant
Journal:  Mutat Res       Date:  1987 Jan-Mar       Impact factor: 2.433

4.  Conformation of 2-aminofluorene-modified DNA.

Authors:  S Broyde; B Hingerty
Journal:  Biopolymers       Date:  1983-11       Impact factor: 2.505

5.  Comparative orientation of the fluorene residue in native DNA modified by N-acetoxy-N-2-acetylaminofluorene and two 7-halogeno derivatives.

Authors:  R P Fuchs; J F Lefevre; J Pouyet; M P Daune
Journal:  Biochemistry       Date:  1976-07-27       Impact factor: 3.162

6.  Induction of mutations by N-acetoxy-N-acetyl-2-aminofluorene modified M13 viral DNA.

Authors:  P K Gupta; R G Pandrangi; M S Lee; C M King
Journal:  Carcinogenesis       Date:  1991-05       Impact factor: 4.944

7.  Identification of the persistently bound form of the carcinogen N-acetyl-2-aminofluorene to rat liver DNA in vivo.

Authors:  J G Westra; E Kriek; H Hittenhausen
Journal:  Chem Biol Interact       Date:  1976-10-02       Impact factor: 5.192

8.  Effect of N-2-acetylaminofluorene modification on the structure and template activity of DNA and reconstituted chromatin.

Authors:  H Yamasaki; S Leffler; I B Weinstein
Journal:  Cancer Res       Date:  1977-03       Impact factor: 12.701

9.  Minor-groove binding models for acetylaminofluorene modified DNA.

Authors:  R Shapiro; B E Hingerty; S Broyde
Journal:  J Biomol Struct Dyn       Date:  1989-12

10.  Single adduct mutagenesis: strong effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.

Authors:  D Burnouf; P Koehl; R P Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205
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