Literature DB >> 23345740

Energy profile of the space of model protein sequences.

G Tiana1, R A Broglia, E I Shakhnovich.   

Abstract

A numerical study of the energy landscape of the space of model proteinsequences is carried out. As a consequence of the heterogeneity of thecontact energies among amino acids, the energy landscape displays a veryrough profile, a behaviour typical of frustrated systems. This givesraise to a hierarchical clustering of low-energy sequences and can have evolutionary consequences.

Keywords:  energy landscapes; model protein; space of sequences

Year:  2001        PMID： 23345740      PMCID： PMC3456584          DOI： 10.1023/A:1013151530254

Source DB:  PubMed          Journal:  J Biol Phys        ISSN： 0092-0606            Impact factor:   1.365


  9 in total

1.  Hiking in the energy landscape in sequence space: a bumpy road to good folders.

Authors:  G Tiana; R A Broglia; E I Shakhnovich
Journal:  Proteins       Date:  2000-05-15

2.  New algorithm for protein design.

Authors: 
Journal:  Phys Rev Lett       Date:  1996-01-08       Impact factor: 9.161

3.  Theory of reversible denaturation of globular proteins.

Authors:  N Go
Journal:  Int J Pept Protein Res       Date:  1975

4.  Proteins with selected sequences fold into unique native conformation.

Authors: 
Journal:  Phys Rev Lett       Date:  1994-06-13       Impact factor: 9.161

5.  Phase diagram of random copolymers.

Authors: 
Journal:  Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics       Date:  1993-07

6.  Emergence of preferred structures in a simple model of protein folding.

Authors:  H Li; R Helling; C Tang; N Wingreen
Journal:  Science       Date:  1996-08-02       Impact factor: 47.728

7.  Design of proteins with selected thermal properties.

Authors:  M P Morrissey; E I Shakhnovich
Journal:  Fold Des       Date:  1996

8.  Formation of unique structure in polypeptide chains. Theoretical investigation with the aid of a replica approach.

Authors:  E I Shakhnovich; A M Gutin
Journal:  Biophys Chem       Date:  1989-11       Impact factor: 2.352

9.  Evolution-like selection of fast-folding model proteins.

Authors:  A M Gutin; V I Abkevich; E I Shakhnovich
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205
  9 in total

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