Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Enterovirus 71 infection cleaves a negative regulator for viral internal ribosomal entry site-driven translation.

Literature DB >> 23345520

Enterovirus 71 infection cleaves a negative regulator for viral internal ribosomal entry site-driven translation.

Li-Lien Chen¹, Yu-An Kung, Kuo-Feng Weng, Jing-Yi Lin, Jim-Tong Horng, Shin-Ru Shih.

Abstract

Far-upstream element-binding protein 2 (FBP2) is an internal ribosomal entry site (IRES) trans-acting factor (ITAF) that negatively regulates enterovirus 71 (EV71) translation. This study shows that EV71 infection cleaved FBP2. Live EV71 and the EV71 replicon (but not UV-inactivated virus particles) induced FBP2 cleavage, suggesting that viral replication results in FBP2 cleavage. The results also showed that virus-induced proteasome, autophagy, and caspase activity co-contribute to EV71-induced FBP2 cleavage. Using FLAG-fused FBP2, we mapped the potential cleavage fragments of FBP2 in infected cells. We also found that FBP2 altered its function when its carboxyl terminus was cleaved. This study presents a mechanism for virus-induced cellular events to cleave a negative regulator for viral IRES-driven translation.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23345520 PMCID： PMC3624201 DOI： 10.1128/JVI.02278-12

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

64 in total

1. Diverse apoptotic pathways in enterovirus 71-infected cells.

Authors: Shih-Cheng Chang; Jing-Yi Lin; Lily Yen-cheng Lo; Mei-Ling Li; Shin-Ru Shih
Journal: J Neurovirol Date: 2004-12 Impact factor: 2.643

Review 2. Targeting of host-cell ubiquitin pathways by viruses.

Authors: Julia Shackelford; Joseph S Pagano
Journal: Essays Biochem Date: 2005 Impact factor: 8.000

Review 3. Proteolysis: from the lysosome to ubiquitin and the proteasome.

Authors: Aaron Ciechanover
Journal: Nat Rev Mol Cell Biol Date: 2005-01 Impact factor: 94.444

4. Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay.

Authors: Chu-Fang Chou; Alok Mulky; Sushmit Maitra; Wei-Jye Lin; Roberto Gherzi; John Kappes; Ching-Yi Chen
Journal: Mol Cell Biol Date: 2006-05 Impact factor: 4.272

5. Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff?

Authors: V Kerekatte; B D Keiper; C Badorff; A Cai; K U Knowlton; R E Rhoads
Journal: J Virol Date: 1999-01 Impact factor: 5.103

6. Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA.

Authors: L B Blyn; J S Towner; B L Semler; E Ehrenfeld
Journal: J Virol Date: 1997-08 Impact factor: 5.103

7. An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group.

Authors: M Ho; E R Chen; K H Hsu; S J Twu; K T Chen; S F Tsai; J R Wang; S R Shih
Journal: N Engl J Med Date: 1999-09-23 Impact factor: 91.245

8. Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia.

Authors: S AbuBakar; H Y Chee; M F Al-Kobaisi; J Xiaoshan; K B Chua; S K Lam
Journal: Virus Res Date: 1999-05 Impact factor: 3.303

9. Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites.

Authors: G Johannes; P Sarnow
Journal: RNA Date: 1998-12 Impact factor: 4.942

10. Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro.

Authors: M Joachims; P C Van Breugel; R E Lloyd
Journal: J Virol Date: 1999-01 Impact factor: 5.103

21 in total

1. Cellular mRNA decay protein AUF1 negatively regulates enterovirus and human rhinovirus infections.

Authors: Andrea L Cathcart; Janet M Rozovics; Bert L Semler
Journal: J Virol Date: 2013-07-31 Impact factor: 5.103

2. hnRNP K Is a Novel Internal Ribosomal Entry Site-Transacting Factor That Negatively Regulates Foot-and-Mouth Disease Virus Translation and Replication and Is Antagonized by Viral 3C Protease.

Authors: Wenming Liu; Decheng Yang; Chao Sun; Haiwei Wang; Bo Zhao; Guohui Zhou; Li Yu
Journal: J Virol Date: 2020-08-17 Impact factor: 5.103

Review 3. Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease.

Authors: Paola Briata; Domenico Bordo; Margherita Puppo; Franco Gorlero; Martina Rossi; Nora Perrone-Bizzozero; Roberto Gherzi
Journal: Wiley Interdiscip Rev RNA Date: 2015-12-27 Impact factor: 9.957

Review 4. Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation.

Authors: Alejandro Velázquez-Cruz; Blanca Baños-Jaime; Antonio Díaz-Quintana; Miguel A De la Rosa; Irene Díaz-Moreno
Journal: Front Mol Biosci Date: 2021-04-27

Review 5. Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus.

Authors: Dylan Flather; Bert L Semler
Journal: Front Microbiol Date: 2015-06-18 Impact factor: 5.640

6. A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells.

Authors: Kuo-Feng Weng; Chuan-Tien Hung; Po-Ting Hsieh; Mei-Ling Li; Guang-Wu Chen; Yu-An Kung; Peng-Nien Huang; Rei-Lin Kuo; Li-Lien Chen; Jing-Yi Lin; Robert Yung-Liang Wang; Shu-Jen Chen; Petrus Tang; Jim-Tong Horng; Hsing-I Huang; Jen-Ren Wang; David M Ojcius; Gary Brewer; Shin-Ru Shih
Journal: Nucleic Acids Res Date: 2014-10-28 Impact factor: 16.971