Literature DB >> 23344544

p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis.

Xiaohua Su1, Deepavali Chakravarti, Elsa R Flores.   

Abstract

The role of p63 in cancer has been an area of intense debate and controversy. Is TP63 (which encodes p63) a tumour suppressor gene or an oncogene? This debate is partly due to the complexity of the gene. There are several p63 isoforms - some with tumour suppressive functions and others with oncogenic functions. In this Opinion article, we focus on the recent advances in understanding p63 biology and its roles in cancer. In this regard, we discuss the role of p63 in multiple stem cell compartments, ageing, in the response to DNA damage and in DNA repair. Finally, we highlight the importance of understanding the interactions between all three p53 family members and the potential impact of this knowledge on cancer therapy and regenerative medicine.

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Year:  2013        PMID： 23344544      PMCID： PMC4181578          DOI： 10.1038/nrc3446

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  98 in total

1.  MDM2 suppresses p73 function without promoting p73 degradation.

Authors:  X Zeng; L Chen; C A Jost; R Maya; D Keller; X Wang; W G Kaelin; M Oren; J Chen; H Lu
Journal:  Mol Cell Biol       Date:  1999-05       Impact factor: 4.272

2.  Perp is a p63-regulated gene essential for epithelial integrity.

Authors:  Rebecca A Ihrie; Michelle R Marques; Bichchau T Nguyen; Jennifer S Horner; Cristian Papazoglu; Roderick T Bronson; Alea A Mills; Laura D Attardi
Journal:  Cell       Date:  2005-03-25       Impact factor: 41.582

3.  While p73 is essential, p63 is completely dispensable for the development of the central nervous system.

Authors:  Lena Holembowski; Ramona Schulz; Flaminia Talos; Andreas Scheel; Sonja Wolff; Matthias Dobbelstein; Ute Moll
Journal:  Cell Cycle       Date:  2011-02-15       Impact factor: 4.534

4.  Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.

Authors:  Xiaohua Su; Min Soon Cho; Young-Jin Gi; Bernard A Ayanga; Charles J Sherr; Elsa R Flores
Journal:  EMBO J       Date:  2009-06-04       Impact factor: 11.598

5.  p63 induces key target genes required for epidermal morphogenesis.

Authors:  Maranke I Koster; Daisy Dai; Barbara Marinari; Yuji Sano; Antonio Costanzo; Michael Karin; Dennis R Roop
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-20       Impact factor: 11.205

Review 6.  The P53 pathway: what questions remain to be explored?

Authors:  A J Levine; W Hu; Z Feng
Journal:  Cell Death Differ       Date:  2006-06       Impact factor: 15.828

7.  TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.

Authors:  Richard Tomasini; Katsuya Tsuchihara; Margareta Wilhelm; Masashi Fujitani; Alessandro Rufini; Carol C Cheung; Fatima Khan; Annick Itie-Youten; Andrew Wakeham; Ming-Sound Tsao; Juan L Iovanna; Jeremy Squire; Igor Jurisica; David Kaplan; Gerry Melino; Andrea Jurisicova; Tak W Mak
Journal:  Genes Dev       Date:  2008-09-19       Impact factor: 11.361

8.  Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis.

Authors:  R Agami; G Blandino; M Oren; Y Shaul
Journal:  Nature       Date:  1999-06-24       Impact factor: 49.962

9.  The E3 ubiquitin ligase Itch controls the protein stability of p63.

Authors:  Mario Rossi; Rami I Aqeilan; Michael Neale; Eleonora Candi; Paolo Salomoni; Richard A Knight; Carlo M Croce; Gerry Melino
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-14       Impact factor: 11.205

10.  p63 and p73 transcriptionally regulate genes involved in DNA repair.

Authors:  Yu-Li Lin; Shomit Sengupta; Katherine Gurdziel; George W Bell; Tyler Jacks; Elsa R Flores
Journal:  PLoS Genet       Date:  2009-10-09       Impact factor: 5.917
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  77 in total

1.  Targeted therapies for locally advanced or metastatic squamous cell carcinoma of the lung.

Authors:  Thomas E Stinchcombe
Journal:  Curr Treat Options Oncol       Date:  2013-12

2.  Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes.

Authors:  Hussein A Abbas; Ngoc Hoang Bao Bui; Kimal Rajapakshe; Justin Wong; Preethi Gunaratne; Kenneth Y Tsai; Cristian Coarfa; Elsa R Flores
Journal:  Cancer Res       Date:  2017-11-27       Impact factor: 12.701

3.  FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells.

Authors:  Martine van Keimpema; Leonie J Grüneberg; Michal Mokry; Ruben van Boxtel; Jan Koster; Paul J Coffer; Steven T Pals; Marcel Spaargaren
Journal:  Blood       Date:  2014-09-29       Impact factor: 22.113

4.  T538 phosphorylation, Pin-ing p63-Itch stability.

Authors:  Akram Alian; Rami I Aqeilan
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

5.  The family that eats together stays together: new p53 family transcriptional targets in autophagy.

Authors:  Marco Napoli; Elsa R Flores
Journal:  Genes Dev       Date:  2013-05-01       Impact factor: 11.361

6.  Decreased TAp63 and ΔNp63 mRNA Levels in Most Human Pituitary Adenomas Are Correlated with Notch3/Jagged1 Relative Expression.

Authors:  Lisiane Cervieri Mezzomo; Frederico Giacomoni Pesce; Josenel Maria Barcelos Marçal; Taiana Haag; Nelson Pires Ferreira; Julia Fernanda Semmelmann Pereira Lima; Carolina Garcia Soares Leães; Miriam Costa Oliveira; Maria Beatriz da Fonte Kohek
Journal:  Endocr Pathol       Date:  2017-03       Impact factor: 3.943

7.  ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program.

Authors:  Tuyen T Dang; Matthew A Esparza; Erin A Maine; Jill M Westcott; Gray W Pearson
Journal:  Cancer Res       Date:  2015-08-19       Impact factor: 12.701

8.  ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation.

Authors:  Masaharu Hazawa; De-Chen Lin; Akiko Kobayashi; Yan-Yi Jiang; Liang Xu; Firli Rahmah Primula Dewi; Mahmoud Shaaban Mohamed; Mitsutoshi Nakada; Makiko Meguro-Horike; Shin-Ichi Horike; H Phillip Koeffler; Richard W Wong
Journal:  EMBO Rep       Date:  2017-12-07       Impact factor: 8.807

9.  Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds.

Authors:  Naing Lin Shan; Audrey Minden; Philip Furmanski; Min Ji Bak; Li Cai; Roman Wernyj; Davit Sargsyan; David Cheng; Renyi Wu; Hsiao-Chen D Kuo; Shanyi N Li; Mingzhu Fang; Hubert Maehr; Ah-Ng Kong; Nanjoo Suh
Journal:  Cancer Prev Res (Phila)       Date:  2020-05-28

10.  Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73.

Authors:  Avinashnarayan Venkatanarayan; Payal Raulji; William Norton; Elsa R Flores
Journal:  Cell Cycle       Date:  2016       Impact factor: 4.534
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