Literature DB >> 23341104

Bioinformatics analysis reveals potential candidate drugs for HCC.

Xiao-Bing Huang1, Jing Li, Lu Zheng, Guo-Hua Zuo, Ke-Qiang Han, Hong-Yan Li, Ping Liang.   

Abstract

In our study, we used the GSE17967 series to identify differentially expressed genes between cirrhosis and hepatocellular carcinoma, aiming to analyse the mechanism of the progression of cirrhosis to hepatocellular carcinoma and identify the sub-pathways closely related to this progression, and find the small molecule drugs to interfere this progression. From the result of our study, we find that many small molecule drugs closely related with carcinoma have been linked by our method. We also find some new small molecule drugs related to this progression. It is demonstrated that bioinformatics analysis is useful in identification of the candidate drugs in hepatocellular carcinoma.

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Year:  2013        PMID: 23341104     DOI: 10.1007/s12253-012-9576-y

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN: 1219-4956            Impact factor:   3.201


  18 in total

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Review 2.  The KEGG database.

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3.  Linear models and empirical bayes methods for assessing differential expression in microarray experiments.

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Review 4.  Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.

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Journal:  Nat Rev Cancer       Date:  2006-01       Impact factor: 60.716

Review 5.  Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug.

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Journal:  Nat Biotechnol       Date:  2007-01       Impact factor: 54.908

Review 6.  Clinical development of histone deacetylase inhibitors as anticancer agents.

Authors:  Daryl C Drummond; Charles O Noble; Dmitri B Kirpotin; Zexiong Guo; Gary K Scott; Christopher C Benz
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7.  Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes.

Authors:  Hua Su; Nan Hu; Howard H Yang; Chaoyu Wang; Mikiko Takikita; Quan-Hong Wang; Carol Giffen; Robert Clifford; Stephen M Hewitt; Jian-Zhong Shou; Alisa M Goldstein; Maxwell P Lee; Philip R Taylor
Journal:  Clin Cancer Res       Date:  2011-03-08       Impact factor: 12.531

8.  Long-term prognosis in hepatocellular carcinoma patients after hepatectomy.

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Journal:  Asian Pac J Cancer Prev       Date:  2012

9.  Gene expression analysis in burn wounds of rats.

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Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2002-10       Impact factor: 3.619

10.  Hepatocellular carcinoma in Italian patients with cirrhosis.

Authors:  M Colombo; R de Franchis; E Del Ninno; A Sangiovanni; C De Fazio; M Tommasini; M F Donato; A Piva; V Di Carlo; N Dioguardi
Journal:  N Engl J Med       Date:  1991-09-05       Impact factor: 91.245

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  5 in total

1.  Huaier Suppresses the Hepatocellular Carcinoma Cell Cycle by Regulating Minichromosome Maintenance Proteins.

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2.  Expression of asialoglycoprotein receptor 1 in human hepatocellular carcinoma.

Authors:  Bin Shi; Marc Abrams; Laura Sepp-Lorenzino
Journal:  J Histochem Cytochem       Date:  2013-08-26       Impact factor: 2.479

Review 3.  Role of MicroRNAs in Hepatocellular Carcinoma.

Authors:  Zixiang Zhu; Xiangle Zhang; Guoqing Wang; Haixue Zheng
Journal:  Hepat Mon       Date:  2014-08-01       Impact factor: 0.660

4.  Identification of molecular target genes and key pathways in hepatocellular carcinoma by bioinformatics analysis.

Authors:  Lei Zhou; Yanyan Du; Lingqun Kong; Xingyuan Zhang; Qiangpu Chen
Journal:  Onco Targets Ther       Date:  2018-04-04       Impact factor: 4.147

Review 5.  Dysregulated MicroRNA Fingerprints and Methylation Patterns in Hepatocellular Carcinoma, Cancer Stem Cells, and Mesenchymal Stem Cells.

Authors:  Mohamed A Nasr; Radwa Ayman Salah; M Abd Elkodous; Shimaa E Elshenawy; Nagwa El-Badri
Journal:  Front Cell Dev Biol       Date:  2019-10-17
  5 in total

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