BACKGROUND: Immune system activation is involved in atherosclerosis. Neopterin production and tryptophan catabolism through the kynurenine pathway, measured by the kynurenine-tryptophan ratio (KTR), are induced by interferon gamma, thus both are considered markers of cell mediated immune activation. This study prospectively investigated their predictive value on acute coronary events among Norwegian community-dwelling older adults without previous coronary heart disease. METHODS: 1112 men and 1631 women, 71-74 years old were examined during 1997-99 as part of the Hordaland Health Study. They were followed until an acute coronary event (defined as unstable angina, non-fatal or fatal acute myocardial infarction or sudden death) or December 31, 2006. Kaplan-Meier hazard curves were constructed for quartiles of plasma neopterin and KTR. Cox proportional hazards models adjusted for sex, body mass index, smoking, hypertension, renal function and cholesterol were used to examine the relation between neopterin and KTR quartiles and the study endpoint. RESULTS: Median (interquartile range) values were 8.6 (7.2-10.4) nmol/L for neopterin and 25.8 (25.3-31.1) nmol/μmol for KTR. During the follow up, 265 participants had at least one acute coronary event. Increased baseline levels of plasma neopterin and KTR were associated with continuous increased risk of developing the study endpoint (P-values for trend <0.001 and 0.019, respectively). Adjusted hazard ratios comparing the fourth quartile to the first were 1.65 (95% CI; 1.11-2.47; P=0.013) for neopterin and 1.57 (95% CI 1.03-2.39; P=0.036) for KTR. CONCLUSION: Plasma neopterin and KTR levels predict acute coronary events in older adults without previous coronary heart disease.
BACKGROUND: Immune system activation is involved in atherosclerosis. Neopterin production and tryptophan catabolism through the kynurenine pathway, measured by the kynurenine-tryptophan ratio (KTR), are induced by interferon gamma, thus both are considered markers of cell mediated immune activation. This study prospectively investigated their predictive value on acute coronary events among Norwegian community-dwelling older adults without previous coronary heart disease. METHODS: 1112 men and 1631 women, 71-74 years old were examined during 1997-99 as part of the Hordaland Health Study. They were followed until an acute coronary event (defined as unstable angina, non-fatal or fatal acute myocardial infarction or sudden death) or December 31, 2006. Kaplan-Meier hazard curves were constructed for quartiles of plasma neopterin and KTR. Cox proportional hazards models adjusted for sex, body mass index, smoking, hypertension, renal function and cholesterol were used to examine the relation between neopterin and KTR quartiles and the study endpoint. RESULTS: Median (interquartile range) values were 8.6 (7.2-10.4) nmol/L for neopterin and 25.8 (25.3-31.1) nmol/μmol for KTR. During the follow up, 265 participants had at least one acute coronary event. Increased baseline levels of plasma neopterin and KTR were associated with continuous increased risk of developing the study endpoint (P-values for trend <0.001 and 0.019, respectively). Adjusted hazard ratios comparing the fourth quartile to the first were 1.65 (95% CI; 1.11-2.47; P=0.013) for neopterin and 1.57 (95% CI 1.03-2.39; P=0.036) for KTR. CONCLUSION: Plasma neopterin and KTR levels predict acute coronary events in older adults without previous coronary heart disease.
Authors: Edward Yu; Miguel Ruiz-Canela; Marta Guasch-Ferré; Yan Zheng; Estefania Toledo; Clary B Clish; Jordi Salas-Salvadó; Liming Liang; Dong D Wang; Dolores Corella; Montse Fitó; Enrique Gómez-Gracia; José Lapetra; Ramón Estruch; Emilio Ros; Montserrat Cofán; Fernando Arós; Dora Romaguera; Lluis Serra-Majem; Jose V Sorlí; Frank B Hu; Miguel A Martinez-Gonzalez Journal: J Nutr Date: 2017-02-08 Impact factor: 4.798
Authors: Qibin Qi; Simin Hua; Clary B Clish; Justin M Scott; David B Hanna; Tao Wang; Sabina A Haberlen; Sanjiv J Shah; Marshall J Glesby; Jason M Lazar; Robert D Burk; Howard N Hodis; Alan L Landay; Wendy S Post; Kathryn Anastos; Robert C Kaplan Journal: Clin Infect Dis Date: 2018-07-02 Impact factor: 9.079
Authors: Marijke A de Vries; Arash Alipour; Erwin Birnie; Andrew Westzaan; Selvetta van Santen; Ellen van der Zwan; Anho H Liem; Noëlle van der Meulen; Manuel Castro Cabezas Journal: Front Med Date: 2016-02-01 Impact factor: 4.592