Hyung-Suk Yoon1, Jae Jeong Yang1, Emilio S Rivera2, Xiao-Ou Shu1, Yong-Bing Xiang3, Marion W Calcutt2, Qiuyin Cai1, Xianglan Zhang4, Honglan Li3, Yu-Tang Gao3, Wei Zheng1, Danxia Yu5. 1. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. 2. Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA. 3. State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 4. Tennessee Department of Health, Nashville, TN, USA. 5. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: danxia.yu@vumc.org.
Abstract
BACKGROUND AND AIMS: Studies have linked several metabolites to the risk of coronary heart disease (CHD) among Western populations, but prospective studies among Asian populations on the metabolite-CHD association remain limited. METHODS AND RESULTS: We evaluated the association of urinary metabolites with CHD risk among Chinese adults in a nested case-control study of 275 incident cases and 275 matched controls (127 pairs of men and 148 pairs of women). Fifty metabolites were measured by a predefined metabolomics panel and adjusted using urinary creatinine. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). After adjusting for traditional CHD risk factors, urinary tryptophan showed a positive association with incident CHD: OR (95% CI) for the highest vs. lowest quartiles was 2.02 (1.15-3.56) among all study participants (p-trend = 0.02). The tryptophan-CHD association was more evident among individuals with dyslipidemia than among those without the condition (OR [95% CI] for the highest vs. lowest quartiles = 3.90 [1.86-8.19] and 0.74 [0.26-2.06], respectively; p-interaction<0.01). Other metabolites did not show significant associations with CHD risk among all study participants. However, a positive association of methionine with CHD risk was observed only among women (OR [95% CI] for the highest vs. lowest quartiles = 2.77 [1.17-6.58]; p-interaction = 0.03), and an inverse association of inosine with CHD risk was observed only among men (OR [95% CI] for the highest vs. lowest quartiles = 0.29 [0.11-0.81]; p-interaction = 0.04). CONCLUSION: Elevated urinary tryptophan may be related to CHD risk among Chinese adults, especially for those with dyslipidemia.
BACKGROUND AND AIMS: Studies have linked several metabolites to the risk of coronary heart disease (CHD) among Western populations, but prospective studies among Asian populations on the metabolite-CHD association remain limited. METHODS AND RESULTS: We evaluated the association of urinary metabolites with CHD risk among Chinese adults in a nested case-control study of 275 incident cases and 275 matched controls (127 pairs of men and 148 pairs of women). Fifty metabolites were measured by a predefined metabolomics panel and adjusted using urinary creatinine. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). After adjusting for traditional CHD risk factors, urinary tryptophan showed a positive association with incident CHD: OR (95% CI) for the highest vs. lowest quartiles was 2.02 (1.15-3.56) among all study participants (p-trend = 0.02). The tryptophan-CHD association was more evident among individuals with dyslipidemia than among those without the condition (OR [95% CI] for the highest vs. lowest quartiles = 3.90 [1.86-8.19] and 0.74 [0.26-2.06], respectively; p-interaction<0.01). Other metabolites did not show significant associations with CHD risk among all study participants. However, a positive association of methionine with CHD risk was observed only among women (OR [95% CI] for the highest vs. lowest quartiles = 2.77 [1.17-6.58]; p-interaction = 0.03), and an inverse association of inosine with CHD risk was observed only among men (OR [95% CI] for the highest vs. lowest quartiles = 0.29 [0.11-0.81]; p-interaction = 0.04). CONCLUSION: Elevated urinary tryptophan may be related to CHD risk among Chinese adults, especially for those with dyslipidemia.
Authors: Anika A M Vaarhorst; Aswin Verhoeven; Claudia M Weller; Stefan Böhringer; Sibel Göraler; Axel Meissner; André M Deelder; Peter Henneman; Anton P M Gorgels; Piet A van den Brandt; Leo J Schouten; Marleen M van Greevenbroek; Audrey H H Merry; W M Monique Verschuren; Arn M J M van den Maagdenberg; Ko Willems van Dijk; Aaron Isaacs; Dorret Boomsma; Ben A Oostra; Cornelia M van Duijn; J Wouter Jukema; Jolanda M A Boer; Edith Feskens; Bastiaan T Heijmans; P Eline Slagboom Journal: Am Heart J Date: 2014-04-04 Impact factor: 4.749
Authors: Zeneng Wang; Elizabeth Klipfell; Brian J Bennett; Robert Koeth; Bruce S Levison; Brandon Dugar; Ariel E Feldstein; Earl B Britt; Xiaoming Fu; Yoon-Mi Chung; Yuping Wu; Phil Schauer; Jonathan D Smith; Hooman Allayee; W H Wilson Tang; Joseph A DiDonato; Aldons J Lusis; Stanley L Hazen Journal: Nature Date: 2011-04-07 Impact factor: 49.962
Authors: Andrea Ganna; Samira Salihovic; Johan Sundström; Corey D Broeckling; Asa K Hedman; Patrik K E Magnusson; Nancy L Pedersen; Anders Larsson; Agneta Siegbahn; Mihkel Zilmer; Jessica Prenni; Johan Arnlöv; Lars Lind; Tove Fall; Erik Ingelsson Journal: PLoS Genet Date: 2014-12-11 Impact factor: 5.917
Authors: Marta Guasch-Ferré; Frank B Hu; Miguel Ruiz-Canela; Mònica Bulló; Estefanía Toledo; Dong D Wang; Dolores Corella; Enrique Gómez-Gracia; Miquel Fiol; Ramon Estruch; José Lapetra; Montserrat Fitó; Fernando Arós; Lluís Serra-Majem; Emilio Ros; Courtney Dennis; Liming Liang; Clary B Clish; Miguel A Martínez-González; Jordi Salas-Salvadó Journal: J Am Heart Assoc Date: 2017-10-28 Impact factor: 5.501
Authors: Tuulia Tynkkynen; Qin Wang; Jussi Ekholm; Olga Anufrieva; Pauli Ohukainen; Jouko Vepsäläinen; Minna Männikkö; Sirkka Keinänen-Kiukaanniemi; Michael V Holmes; Matthew Goodwin; Susan Ring; John C Chambers; Jaspal Kooner; Marjo-Riitta Järvelin; Johannes Kettunen; Michael Hill; George Davey Smith; Mika Ala-Korpela Journal: Int J Epidemiol Date: 2019-06-01 Impact factor: 7.196