Literature DB >> 23336263

Understanding and treating blast traumatic brain injury in the combat theater.

Ernest W Wang1, Jason H Huang.   

Abstract

OBJECTIVES: Blast injury is a frequent cause of traumatic brain injury (TBI) in the modern combat theater. We sought to explain the research and treatment associated with this injury.
METHODS: We reviewed literature on the prevalence of blast TBI (bTBI), blast injury mechanisms, research, and perspectives on the neurosurgical experience treating bTBI.
RESULTS: A majority of combat-related casualties in recent wars are due to blast. A majority of survivors of blast injuries are diagnosed with TBI. Blast injury may induce changes in the brain not seen with non-blast-related mechanisms. However, long-term symptoms are not significantly different from non-blast mechanisms. Aggressive decompressive craniectomies are commonly performed in the combat theater. DISCUSSION: Due to the prevalence and debilitating nature of bTBI, understanding injury mechanisms is crucial in treating the injury before symptoms become permanent. Treatment is currently limited to decompressive craniectomies, which are the most effective treatment for a relatively young and fit military population.

Entities:  

Mesh:

Year:  2012        PMID: 23336263     DOI: 10.1179/1743132812Y.0000000138

Source DB:  PubMed          Journal:  Neurol Res        ISSN: 0161-6412            Impact factor:   2.448


  5 in total

1.  A combat casualty relevant dismounted complex blast injury model in swine.

Authors:  Alexis L Cralley; Ernest E Moore; Daniel Kissau; Julia R Coleman; Navin Vigneshwar; Margot DeBot; Terry R Schaid; Hunter B Moore; Mitchell J Cohen; Kirk Hansen; Christopher C Silliman; Angela Sauaia; Charles J Fox
Journal:  J Trauma Acute Care Surg       Date:  2022-05-12       Impact factor: 3.697

Review 2.  Emerging Approaches to Neurocircuits in PTSD and TBI: Imaging the Interplay of Neural and Emotional Trauma.

Authors:  Andrea D Spadoni; Mingxiong Huang; Alan N Simmons
Journal:  Curr Top Behav Neurosci       Date:  2018

Review 3.  Traumatic Brain Injury pathophysiology and treatments: early, intermediate, and late phases post-injury.

Authors:  Hanna Algattas; Jason H Huang
Journal:  Int J Mol Sci       Date:  2013-12-30       Impact factor: 5.923

Review 4.  Considerations for animal models of blast-related traumatic brain injury and chronic traumatic encephalopathy.

Authors:  Lee E Goldstein; Ann C McKee; Patric K Stanton
Journal:  Alzheimers Res Ther       Date:  2014-09-05       Impact factor: 6.982

5.  Identification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury.

Authors:  Matthew M Harper; Danielle Rudd; Kacie J Meyer; Anumantha G Kanthasamy; Vellareddy Anantharam; Andrew A Pieper; Edwin Vázquez-Rosa; Min-Kyoo Shin; Kalyani Chaubey; Yeojung Koh; Lucy P Evans; Alexander G Bassuk; Michael G Anderson; Laura Dutca; Indira T Kudva; Manohar John
Journal:  Heliyon       Date:  2020-02-17
  5 in total

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