Päivi E Korhonen 1 , Hannu Kautiainen 2 , Salme Järvenpää 3 , Ilkka Kantola 4 Show Affiliations »
Abstract
BACKGROUND: Little is known about the prevalence of target organ damage in previously undiagnosed hypertension. DESIGN: Cross-sectional population survey. METHODS: We measured ankle-brachial index (ABI), estimated glomerular filtration rate (eGFR), electrocardiographically determined left ventricular hypertrophy (ECG-LVH), and cardiometabolic risk factors in subjects with previously undiagnosed hypertension (n = 138) and normotensive (n = 440) risk subjects, who had metabolic syndrome, glucose disorders, body mass index ≥ 30 kg/m(2) or a 10-year risk of cardiovascular disease death of 5% or more according to the Systematic Coronary Risk Evaluation (SCORE) system. None of the subjects had established cardiovascular or renal disease or previously diagnosed diabetes. RESULTS: There was no difference (p = 0.68) among the studied age-groups in the prevalence of previously undiagnosed hypertension, and no interaction (p = 0.10) was found between sex and age groups. Evidence of subclinical organ damage defined as ECG-LVH, ABI ≤ 0.90, or eGFR < 60 ml/min/1.73 m(2) were found in 22% of the subjects with previously undiagnosed hypertension, and 8% of the non-hypertensive risk persons (p < 0.001). The prevalence of renal insufficiency did not differ between the study groups. Majority of the subjects with previously undiagnosed hypertension also have multiple cardiometabolic risk factors. CONCLUSIONS: Among subjects with previously undiagnosed hypertension, one in five patients had evidence of subclinical target organ damage, and three in four patients may be regarded as having high cardiovascular risk. © The European Society of Cardiology 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
BACKGROUND: Little is known about the prevalence of target organ damage in previously undiagnosed hypertension . DESIGN: Cross-sectional population survey. METHODS: We measured ankle-brachial index (ABI), estimated glomerular filtration rate (eGFR), electrocardiographically determined left ventricular hypertrophy (ECG-LVH), and cardiometabolic risk factors in subjects with previously undiagnosed hypertension (n = 138) and normotensive (n = 440) risk subjects, who had metabolic syndrome , glucose disorders , body mass index ≥ 30 kg/m(2) or a 10-year risk of cardiovascular disease death of 5% or more according to the Systematic Coronary Risk Evaluation (SCORE) system. None of the subjects had established cardiovascular or renal disease or previously diagnosed diabetes . RESULTS: There was no difference (p = 0.68) among the studied age-groups in the prevalence of previously undiagnosed hypertension , and no interaction (p = 0.10) was found between sex and age groups. Evidence of subclinical organ damage defined as ECG-LVH, ABI ≤ 0.90, or eGFR < 60 ml/min/1.73 m(2) were found in 22% of the subjects with previously undiagnosed hypertension , and 8% of the non-hypertensive risk persons (p < 0.001). The prevalence of renal insufficiency did not differ between the study groups. Majority of the subjects with previously undiagnosed hypertension also have multiple cardiometabolic risk factors. CONCLUSIONS: Among subjects with previously undiagnosed hypertension , one in five patients had evidence of subclinical target organ damage, and three in four patients may be regarded as having high cardiovascular risk. © The European Society of Cardiology 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Entities: Disease
Species
Keywords:
Hypertension; left ventricular hypertrophy; peripheral arterial disease; renal insufficiency; risk factors
Mesh： See more »
Year: 2013
PMID： 23335655 DOI： 10.1177/2047487312474530
Source DB: PubMed Journal: Eur J Prev Cardiol ISSN： 2047-4873 Impact factor: 7.804