Literature DB >> 23334669

XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells.

Céline Vallot1, Christophe Huret, Yann Lesecque, Alissa Resch, Noufissa Oudrhiri, Annelise Bennaceur-Griscelli, Laurent Duret, Claire Rougeulle.   

Abstract

X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here we report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence of XIST, XACT is expressed from both X chromosomes in humans but not in mice, suggesting a unique role for XACT in the control of human XCI initiation.

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Year:  2013        PMID： 23334669     DOI： 10.1038/ng.2530

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

1.  Epigenetic dynamics of imprinted X inactivation during early mouse development.

Authors:  Ikuhiro Okamoto; Arie P Otte; C David Allis; Danny Reinberg; Edith Heard
Journal:  Science       Date:  2003-12-11       Impact factor: 47.728

Review 2.  Regulation of X-chromosome inactivation by the X-inactivation centre.

Authors:  Sandrine Augui; Elphège P Nora; Edith Heard
Journal:  Nat Rev Genet       Date:  2011-06       Impact factor: 53.242

3.  Human mesenchymal stem cells derived from induced pluripotent stem cells down-regulate NK-cell cytolytic machinery.

Authors:  Massimo Giuliani; Noufissa Oudrhiri; Zaeem M Noman; Amelia Vernochet; Salem Chouaib; Bruno Azzarone; Antoine Durrbach; Annelise Bennaceur-Griscelli
Journal:  Blood       Date:  2011-07-29       Impact factor: 22.113

4.  Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development.

Authors:  Ikuhiro Okamoto; Catherine Patrat; Dominique Thépot; Nathalie Peynot; Patricia Fauque; Nathalie Daniel; Patricia Diabangouaya; Jean-Philippe Wolf; Jean-Paul Renard; Véronique Duranthon; Edith Heard
Journal:  Nature       Date:  2011-04-06       Impact factor: 49.962

5.  Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.

Authors:  Mitchell Guttman; Ido Amit; Manuel Garber; Courtney French; Michael F Lin; David Feldser; Maite Huarte; Or Zuk; Bryce W Carey; John P Cassady; Moran N Cabili; Rudolf Jaenisch; Tarjei S Mikkelsen; Tyler Jacks; Nir Hacohen; Bradley E Bernstein; Manolis Kellis; Aviv Regev; John L Rinn; Eric S Lander
Journal:  Nature       Date:  2009-02-01       Impact factor: 49.962

6.  Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression.

Authors:  Ahmad M Khalil; Mitchell Guttman; Maite Huarte; Manuel Garber; Arjun Raj; Dianali Rivea Morales; Kelly Thomas; Aviva Presser; Bradley E Bernstein; Alexander van Oudenaarden; Aviv Regev; Eric S Lander; John L Rinn
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-01       Impact factor: 11.205

7.  Erosion of dosage compensation impacts human iPSC disease modeling.

Authors:  Shila Mekhoubad; Christoph Bock; A Sophie de Boer; Evangelos Kiskinis; Alexander Meissner; Kevin Eggan
Journal:  Cell Stem Cell       Date:  2012-05-04       Impact factor: 24.633

8.  A user's guide to the encyclopedia of DNA elements (ENCODE).

Authors: 
Journal:  PLoS Biol       Date:  2011-04-19       Impact factor: 8.029

9.  Repeated recruitment of LTR retrotransposons as promoters by the anti-apoptotic locus NAIP during mammalian evolution.

Authors:  Mark T Romanish; Wynne M Lock; Louie N van de Lagemaat; Catherine A Dunn; Dixie L Mager
Journal:  PLoS Genet       Date:  2006-12-06       Impact factor: 5.917

Review 10.  Mammalian RNA polymerase II core promoters: insights from genome-wide studies.

Authors:  Albin Sandelin; Piero Carninci; Boris Lenhard; Jasmina Ponjavic; Yoshihide Hayashizaki; David A Hume
Journal:  Nat Rev Genet       Date:  2007-05-08       Impact factor: 53.242
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  56 in total

Review 1.  Divergent actions of long noncoding RNAs on X-chromosome remodelling in mammals and Drosophila achieve the same end result: dosage compensation.

Authors:  Subhash C Lakhotia
Journal:  J Genet       Date:  2015-12       Impact factor: 1.166

2.  No imprinted XIST expression in pigs: biallelic XIST expression in early embryos and random X inactivation in placentas.

Authors:  Huiying Zou; Dawei Yu; Xuguang Du; Jing Wang; Lei Chen; Yangyang Wang; Huitao Xu; Yunxuan Zhao; Shanjiang Zhao; Yunwei Pang; Yan Liu; Haisheng Hao; Xueming Zhao; Weihua Du; Yunping Dai; Ning Li; Sen Wu; Huabin Zhu
Journal:  Cell Mol Life Sci       Date:  2019-05-28       Impact factor: 9.261

Review 3.  Long noncoding RNA and its contribution to autism spectrum disorders.

Authors:  Jie Tang; Yizhen Yu; Wei Yang
Journal:  CNS Neurosci Ther       Date:  2017-06-20       Impact factor: 5.243

Review 4.  The sex bias in systemic sclerosis: on the possible mechanisms underlying the female disease preponderance.

Authors:  Fabio D'Amico; Evangelia Skarmoutsou; Maria Clorinda Mazzarino
Journal:  Clin Rev Allergy Immunol       Date:  2014-12       Impact factor: 8.667

Review 5.  The X chromosome in space.

Authors:  Teddy Jégu; Eric Aeby; Jeannie T Lee
Journal:  Nat Rev Genet       Date:  2017-05-08       Impact factor: 53.242

Review 6.  Epigenetics with special reference to the human X chromosome inactivation and the enigma of Drosophila DNA methylation.

Authors:  Deepti Deobagkar
Journal:  J Genet       Date:  2018-06       Impact factor: 1.166

7.  New Advances in Human X chromosome status from a Developmental and Stem Cell Biology.

Authors:  Benjamin Patterson; Yoshiaki Tanaka; In-Hyun Park
Journal:  Tissue Eng Regen Med       Date:  2017-11-22       Impact factor: 4.169

Review 8.  Progress in understanding the molecular mechanism of Xist RNA function through genetics.

Authors:  Asun Monfort; Anton Wutz
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2017-11-05       Impact factor: 6.237

Review 9.  Long non-coding RNAs: modulators of nuclear structure and function.

Authors:  Jan H Bergmann; David L Spector
Journal:  Curr Opin Cell Biol       Date:  2013-09-20       Impact factor: 8.382

10.  Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.

Authors:  Ezgi Hacisuleyman; Loyal A Goff; Cole Trapnell; Adam Williams; Jorge Henao-Mejia; Lei Sun; Patrick McClanahan; David G Hendrickson; Martin Sauvageau; David R Kelley; Michael Morse; Jesse Engreitz; Eric S Lander; Mitch Guttman; Harvey F Lodish; Richard Flavell; Arjun Raj; John L Rinn
Journal:  Nat Struct Mol Biol       Date:  2014-01-26       Impact factor: 15.369
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