Literature DB >> 23333525

The immune system's involvement in obesity-driven type 2 diabetes.

Chengyi Jenny Shu1, Christophe Benoist, Diane Mathis.   

Abstract

Type 2 diabetes is now a worldwide epidemic, strongly correlated with an elevated incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the cross-talk between the immune system and organismal metabolism. This review discusses the connection between inflammation in adipose tissue and systemic insulin resistance, focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this metabolic disease.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23333525      PMCID： PMC3582811          DOI： 10.1016/j.smim.2012.12.001

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  93 in total

1.  PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance.

Authors:  Sang Jun Lee; Ji Young Kim; Ruben Nogueiras; Juan F Linares; Diego Perez-Tilve; Dae Young Jung; Hwi Jin Ko; Susanna M Hofmann; Angela Drew; Michael Leitges; Jason K Kim; Matthias H Tschöp; Maria T Diaz-Meco; Jorge Moscat
Journal:  Cell Metab       Date:  2010-07-07       Impact factor: 27.287

Review 2.  Inflammation and metabolic disorders.

Authors:  Gökhan S Hotamisligil
Journal:  Nature       Date:  2006-12-14       Impact factor: 49.962

Review 3.  Subcutaneous and visceral adipose tissue: structural and functional differences.

Authors:  M Mohsen Ibrahim
Journal:  Obes Rev       Date:  2009-07-28       Impact factor: 9.213

4.  Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice.

Authors:  Yaron Ilan; Ruth Maron; Ann-Marcia Tukpah; Tatiani Uceli Maioli; Gopal Murugaiyan; Kaiyong Yang; Henry Yim Wu; Howard L Weiner
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-05       Impact factor: 11.205

5.  GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.

Authors:  Da Young Oh; Saswata Talukdar; Eun Ju Bae; Takeshi Imamura; Hidetaka Morinaga; WuQiang Fan; Pingping Li; Wendell J Lu; Steven M Watkins; Jerrold M Olefsky
Journal:  Cell       Date:  2010-09-03       Impact factor: 41.582

6.  Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance.

Authors:  Hyunwon Yang; Yun-Hee Youm; Bolormaa Vandanmagsar; Anthony Ravussin; Jeffrey M Gimble; Frank Greenway; Jacqueline M Stephens; Randall L Mynatt; Vishwa Deep Dixit
Journal:  J Immunol       Date:  2010-06-25       Impact factor: 5.422

7.  Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.

Authors:  Jun Kurokawa; Satoko Arai; Katsuhiko Nakashima; Hiromichi Nagano; Akemi Nishijima; Keishi Miyata; Rui Ose; Mayumi Mori; Naoto Kubota; Takashi Kadowaki; Yuichi Oike; Hisashi Koga; Maria Febbraio; Toshihiko Iwanaga; Toru Miyazaki
Journal:  Cell Metab       Date:  2010-06-09       Impact factor: 27.287

Review 8.  Uric acid transport and disease.

Authors:  Alexander So; Bernard Thorens
Journal:  J Clin Invest       Date:  2010-06-01       Impact factor: 14.808

9.  Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance.

Authors:  Jan Mauer; Bhagirath Chaurasia; Leona Plum; Thomas Quast; Brigitte Hampel; Matthias Blüher; Waldemar Kolanus; C Ronald Kahn; Jens C Brüning
Journal:  PLoS Genet       Date:  2010-05-06       Impact factor: 5.917

10.  Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation.

Authors:  Kristiina Rajamäki; Jani Lappalainen; Katariina Oörni; Elina Välimäki; Sampsa Matikainen; Petri T Kovanen; Kari K Eklund
Journal:  PLoS One       Date:  2010-07-23       Impact factor: 3.240
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  70 in total

1.  Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses.

Authors:  Ting Yang; Xiang Gao; Monica Sandberg; Christa Zollbrecht; Xing-Mei Zhang; Michael Hezel; Ming Liu; Maria Peleli; En-Yin Lai; Robert A Harris; A Erik G Persson; Bertil B Fredholm; Leif Jansson; Mattias Carlström
Journal:  Diabetologia       Date:  2015-04-03       Impact factor: 10.122

Review 2.  Invariant natural killer T cells in adipose tissue: novel regulators of immune-mediated metabolic disease.

Authors:  M Rakhshandehroo; E Kalkhoven; M Boes
Journal:  Cell Mol Life Sci       Date:  2013-07-09       Impact factor: 9.261

3.  CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue.

Authors:  W Reid Bolus; Dario A Gutierrez; Arion J Kennedy; Emily K Anderson-Baucum; Alyssa H Hasty
Journal:  J Leukoc Biol       Date:  2015-05-01       Impact factor: 4.962

Review 4.  Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases.

Authors:  Rasha Mofeed Habeeb Mosa; Zhen Zhang; Renfu Shao; Chao Deng; Jiezhong Chen; Chen Chen
Journal:  Endocrine       Date:  2015-02-04       Impact factor: 3.633

5.  Adipose tissue dendritic cell signals are required to maintain T cell homeostasis and obesity-induced expansion.

Authors:  Cara E Porsche; Jennifer B Delproposto; Elise Patrick; Brian F Zamarron; Carey N Lumeng
Journal:  Mol Cell Endocrinol       Date:  2020-01-24       Impact factor: 4.102

Review 6.  Obesity and Aging: Consequences for Cognition, Brain Structure, and Brain Function.

Authors:  Gérard N Bischof; Denise C Park
Journal:  Psychosom Med       Date:  2015 Jul-Aug       Impact factor: 4.312

7.  Adipsin is an adipokine that improves β cell function in diabetes.

Authors:  James C Lo; Sanda Ljubicic; Barbara Leibiger; Matthias Kern; Ingo B Leibiger; Tilo Moede; Molly E Kelly; Diti Chatterjee Bhowmick; Incoronata Murano; Paul Cohen; Alexander S Banks; Melin J Khandekar; Arne Dietrich; Jeffrey S Flier; Saverio Cinti; Matthias Blüher; Nika N Danial; Per-Olof Berggren; Bruce M Spiegelman
Journal:  Cell       Date:  2014-07-03       Impact factor: 41.582

Review 8.  Epigenomic and transcriptional control of insulin resistance.

Authors:  E D Rosen
Journal:  J Intern Med       Date:  2016-10-14       Impact factor: 8.989

9.  Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.

Authors:  Sarah Sczelecki; Aurèle Besse-Patin; Alexandra Abboud; Sandra Kleiner; Dina Laznik-Bogoslavski; Christiane D Wrann; Jorge L Ruas; Benjamin Haibe-Kains; Jennifer L Estall
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-11-26       Impact factor: 4.310

Review 10.  Immune cells and metabolic dysfunction.

Authors:  Ashley Eheim; Dasa Medrikova; Stephan Herzig
Journal:  Semin Immunopathol       Date:  2013-11-09       Impact factor: 9.623
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