Literature DB >> 23333007

Pilot randomized trial of bupropion for adolescent methamphetamine abuse/dependence.

Keith G Heinzerling1, Janette Gadzhyan, Henry van Oudheusden, Felipe Rodriguez, James McCracken, Steven Shoptaw.   

Abstract

PURPOSE: To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents.
METHODS: Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling.
RESULTS: Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo (p = .043) and males (p = .005) respectively.
CONCLUSIONS: Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.
Copyright © 2013 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23333007      PMCID： PMC3608805          DOI： 10.1016/j.jadohealth.2012.10.275

Source DB:  PubMed          Journal:  J Adolesc Health        ISSN： 1054-139X            Impact factor:   5.012


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