Marc N Potenza1. 1. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut; Child Study Center, Yale University School of Medicine, New Haven, Connecticut. Electronic address: marc.potenza@yale.edu.
Abstract
PURPOSE: Despite significant advances in our understanding of the biological bases of addictions, these disorders continue to represent a huge public health burden that is associated with substantial personal suffering. Efforts to target addictions require consideration of how the improved biological understanding of addictions may lead to improved prevention, treatment, and policy initiatives. METHOD: In this article, we provide a narrative review of current biological models for addictions with a goal of placing existing data and theories within a translational and developmental framework targeting the advancement of prevention, treatment, and policy strategies. RESULTS: Data regarding individual differences, intermediary phenotypes, and main and interactive influences of genetic and environmental contributions in the setting of developmental trajectories that may be influenced by addictive drugs or behavior indicate complex underpinnings of addictions. CONCLUSIONS: Consideration and further elucidation of the biological etiologies of addictions hold significant potential for making important gains and reducing the public health impact of addictions.
PURPOSE: Despite significant advances in our understanding of the biological bases of addictions, these disorders continue to represent a huge public health burden that is associated with substantial personal suffering. Efforts to target addictions require consideration of how the improved biological understanding of addictions may lead to improved prevention, treatment, and policy initiatives. METHOD: In this article, we provide a narrative review of current biological models for addictions with a goal of placing existing data and theories within a translational and developmental framework targeting the advancement of prevention, treatment, and policy strategies. RESULTS: Data regarding individual differences, intermediary phenotypes, and main and interactive influences of genetic and environmental contributions in the setting of developmental trajectories that may be influenced by addictive drugs or behavior indicate complex underpinnings of addictions. CONCLUSIONS: Consideration and further elucidation of the biological etiologies of addictions hold significant potential for making important gains and reducing the public health impact of addictions.
Authors: Marc N Potenza; Kwang-ik Adam Hong; Cheryl M Lacadie; Robert K Fulbright; Keri L Tuit; Rajita Sinha Journal: Am J Psychiatry Date: 2012-04 Impact factor: 18.112
Authors: Ahmad R Hariri; Venkata S Mattay; Alessandro Tessitore; Bhaskar Kolachana; Francesco Fera; David Goldman; Michael F Egan; Daniel R Weinberger Journal: Science Date: 2002-07-19 Impact factor: 47.728
Authors: Adilson Marques; Miguel Peralta; Hugo Sarmento; Vânia Loureiro; Élvio R Gouveia; Margarida Gaspar de Matos Journal: Sports Med Date: 2019-02 Impact factor: 11.136
Authors: Sarah W Yip; Songli Mei; Corey E Pilver; Marvin A Steinberg; Loreen J Rugle; Suchitra Krishnan-Sarin; Rani A Hoff; Marc N Potenza Journal: J Gambl Stud Date: 2015-12
Authors: Robert F Leeman; Rani A Hoff; Suchitra Krishnan-Sarin; Julie A Patock-Peckham; Marc N Potenza Journal: J Adolesc Health Date: 2013-11-19 Impact factor: 5.012
Authors: Karolina Kozak; Aliya M Lucatch; Darby J E Lowe; Iris M Balodis; James MacKillop; Tony P George Journal: Ann N Y Acad Sci Date: 2018-10-05 Impact factor: 5.691
Authors: Naomi A Fineberg; Samuel R Chamberlain; Anna E Goudriaan; Dan J Stein; Louk J M J Vanderschuren; Claire M Gillan; Sameer Shekar; Philip A P M Gorwood; Valerie Voon; Sharon Morein-Zamir; Damiaan Denys; Barbara J Sahakian; F Gerard Moeller; Trevor W Robbins; Marc N Potenza Journal: CNS Spectr Date: 2014-02 Impact factor: 3.790