Literature DB >> 23332289

Enigmatic roles of Mcm10 in DNA replication.

Yee Mon Thu1, Anja-Katrin Bielinsky.   

Abstract

Minichromosome maintenance protein 10 (Mcm10) is required for DNA replication in all eukaryotes. Although the exact contribution of Mcm10 to genome replication remains heavily debated, early reports suggested that it promotes DNA unwinding and origin firing. These ideas have been solidified by recent studies that propose a role for Mcm10 in helicase activation. Whereas the molecular underpinnings of this activation step have yet to be revealed, structural data on Mcm10 provide further insight into a possible mechanism of action. The essential role in DNA replication initiation is not mutually exclusive with additional functions that Mcm10 may have as part of the elongation machinery. Here, we review the recent findings regarding the role of Mcm10 in DNA replication and discuss existing controversies.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23332289      PMCID： PMC3608807          DOI： 10.1016/j.tibs.2012.12.003

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  77 in total

1.  Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components.

Authors:  Mai Kanke; Yukako Kodama; Tatsuro S Takahashi; Takuro Nakagawa; Hisao Masukata
Journal:  EMBO J       Date:  2012-03-20       Impact factor: 11.598

Review 2.  Eukaryotic chromosome DNA replication: where, when, and how?

Authors:  Hisao Masai; Seiji Matsumoto; Zhiying You; Naoko Yoshizawa-Sugata; Masako Oda
Journal:  Annu Rev Biochem       Date:  2010       Impact factor: 23.643

3.  Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase.

Authors:  Stephen E Moyer; Peter W Lewis; Michael R Botchan
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-23       Impact factor: 11.205

4.  GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks.

Authors:  Agnieszka Gambus; Richard C Jones; Alberto Sanchez-Diaz; Masato Kanemaki; Frederick van Deursen; Ricky D Edmondson; Karim Labib
Journal:  Nat Cell Biol       Date:  2006-03-12       Impact factor: 28.824

5.  Ultraviolet radiation stress triggers the down-regulation of essential replication factor Mcm10.

Authors:  Aparna Sharma; Manpreet Kaur; Ananya Kar; Sourabh M Ranade; Sandeep Saxena
Journal:  J Biol Chem       Date:  2010-01-11       Impact factor: 5.157

6.  Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45.

Authors:  James A Wohlschlegel; Suman K Dhar; Tatyana A Prokhorova; Anindya Dutta; Johannes C Walter
Journal:  Mol Cell       Date:  2002-02       Impact factor: 17.970

7.  Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.

Authors:  Jennifer A Cobb; Thomas Schleker; Vanesa Rojas; Lotte Bjergbaek; José Antonio Tercero; Susan M Gasser
Journal:  Genes Dev       Date:  2005-12-15       Impact factor: 11.361

8.  Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma.

Authors:  Arjen Koppen; Rachida Ait-Aissa; Jan Koster; Peter G van Sluis; Ingrid Ora; Huib N Caron; Richard Volckmann; Rogier Versteeg; Linda J Valentijn
Journal:  Eur J Cancer       Date:  2007-09-10       Impact factor: 9.162

9.  Self-assembling protein microarrays.

Authors:  Niroshan Ramachandran; Eugenie Hainsworth; Bhupinder Bhullar; Samuel Eisenstein; Benjamin Rosen; Albert Y Lau; Johannes C Walter; Joshua LaBaer
Journal:  Science       Date:  2004-07-02       Impact factor: 47.728

10.  CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

Authors:  Manpreet Kaur; Md Muntaz Khan; Ananya Kar; Aparna Sharma; Sandeep Saxena
Journal:  Nucleic Acids Res       Date:  2012-05-08       Impact factor: 16.971
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  40 in total

1.  Bacterial and Eukaryotic Replisome Machines.

Authors:  Nina Yao; Mike O'Donnell
Journal:  JSM Biochem Mol Biol       Date:  2016-05-30

Review 2.  DNA replication origin activation in space and time.

Authors:  Michalis Fragkos; Olivier Ganier; Philippe Coulombe; Marcel Méchali
Journal:  Nat Rev Mol Cell Biol       Date:  2015-06       Impact factor: 94.444

3.  Mcm10: The glue at replication forks.

Authors:  Anja-Katrin Bielinsky
Journal:  Cell Cycle       Date:  2016-08-02       Impact factor: 4.534

4.  Insights into the Initiation of Eukaryotic DNA Replication.

Authors:  Irina Bruck; Patricia Perez-Arnaiz; Max K Colbert; Daniel L Kaplan
Journal:  Nucleus       Date:  2015-12-28       Impact factor: 4.197

5.  Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair.

Authors:  Jordan R Becker; Hai Dang Nguyen; Xiaohan Wang; Anja-Katrin Bielinsky
Journal:  Cell Cycle       Date:  2014-03-27       Impact factor: 4.534

6.  Interaction between human Ctf4 and the Cdc45/Mcm2-7/GINS (CMG) replicative helicase.

Authors:  Young-Hoon Kang; Andrea Farina; Vladimir P Bermudez; Inger Tappin; Fang Du; Wiebke Chemnitz Galal; Jerard Hurwitz
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-19       Impact factor: 11.205

7.  An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation.

Authors:  Patricia Perez-Arnaiz; Daniel L Kaplan
Journal:  J Mol Biol       Date:  2016-10-15       Impact factor: 5.469

8.  Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression.

Authors:  Yee Mon Thu; Susan Kaye Van Riper; LeeAnn Higgins; Tianji Zhang; Jordan Robert Becker; Todd William Markowski; Hai Dang Nguyen; Timothy Jon Griffin; Anja Katrin Bielinsky
Journal:  Cell Rep       Date:  2016-04-28       Impact factor: 9.423

9.  Multiple functions for Mcm2-7 ATPase motifs during replication initiation.

Authors:  Sukhyun Kang; Megan D Warner; Stephen P Bell
Journal:  Mol Cell       Date:  2014-07-31       Impact factor: 17.970

10.  Mcm10 is required for oogenesis and early embryogenesis in Drosophila.

Authors:  Michael C Reubens; Megan D Biller; Sidney E Bedsole; Lucas T Hopkins; Elizabeth T Ables; Tim W Christensen
Journal:  Mech Dev       Date:  2015-09-12       Impact factor: 1.882
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