Literature DB >> 23329114

The heritability of human disease: estimation, uses and abuses.

Albert Tenesa1, Chris S Haley.   

Abstract

Relatives provide the basic material for the study of inheritance of human disease. However, the methodologies for the estimation of heritability and the interpretation of the results have been controversial. The debate arises from the plethora of methods used, the validity of the methodological assumptions and the inconsistent and sometimes erroneous genetic interpretations made. We will discuss how to estimate disease heritability, how to interpret it, how biases in heritability estimates arise and how heritability relates to other measures of familial disease aggregation.

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Year:  2013        PMID： 23329114     DOI： 10.1038/nrg3377

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  63 in total

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Journal:  J Hypertens       Date:  1996-08       Impact factor: 4.844

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Journal:  Am J Hum Genet       Date:  1974-07       Impact factor: 11.025

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10.  Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

Authors:  Shaun M Purcell; Naomi R Wray; Jennifer L Stone; Peter M Visscher; Michael C O'Donovan; Patrick F Sullivan; Pamela Sklar
Journal:  Nature       Date:  2009-07-01       Impact factor: 49.962
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  102 in total

1.  Gene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING Studies.

Authors:  Azra Kurbasic; Alaitz Poveda; Yan Chen; Asa Agren; Elisabeth Engberg; Frank B Hu; Ingegerd Johansson; Ines Barroso; Anders Brändström; Göran Hallmans; Frida Renström; Paul W Franks
Journal:  Curr Nutr Rep       Date:  2014-12-01

2.  Integrating Nonadditive Genomic Relationship Matrices into the Study of Genetic Architecture of Complex Traits.

Authors:  Alireza Nazarian; Salvador A Gezan
Journal:  J Hered       Date:  2015-12-27       Impact factor: 2.645

3.  Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs.

Authors:  Gibran Hemani; Jian Yang; Anna Vinkhuyzen; Joseph E Powell; Gonneke Willemsen; Jouke-Jan Hottenga; Abdel Abdellaoui; Massimo Mangino; Ana M Valdes; Sarah E Medland; Pamela A Madden; Andrew C Heath; Anjali K Henders; Dale R Nyholt; Eco J C de Geus; Patrik K E Magnusson; Erik Ingelsson; Grant W Montgomery; Timothy D Spector; Dorret I Boomsma; Nancy L Pedersen; Nicholas G Martin; Peter M Visscher
Journal:  Am J Hum Genet       Date:  2013-10-31       Impact factor: 11.025

Review 4.  The paradox of intelligence: Heritability and malleability coexist in hidden gene-environment interplay.

Authors:  Bruno Sauce; Louis D Matzel
Journal:  Psychol Bull       Date:  2017-10-30       Impact factor: 17.737

5.  [Genetics of atopic eczema. An update].

Authors:  E Rodríguez; S Weidinger
Journal:  Hautarzt       Date:  2015-02       Impact factor: 0.751

6.  What Is the Heritability of Periodontitis? A Systematic Review.

Authors:  L Nibali; J Bayliss-Chapman; S A Almofareh; Y Zhou; K Divaris; A R Vieira
Journal:  J Dent Res       Date:  2019-06       Impact factor: 6.116

Review 7.  Missing heritability of complex diseases: case solved?

Authors:  Emmanuelle Génin
Journal:  Hum Genet       Date:  2019-06-04       Impact factor: 4.132

8.  The latent class twin method.

Authors:  Stuart G Baker
Journal:  Biometrics       Date:  2016-01-11       Impact factor: 2.571

9.  Family-based association analysis of alcohol dependence criteria and severity.

Authors:  Leah Wetherill; Manav Kapoor; Arpana Agrawal; Kathleen Bucholz; Daniel Koller; Sarah E Bertelsen; Nhung Le; Jen-Chyong Wang; Laura Almasy; Victor Hesselbrock; John Kramer; John I Nurnberger; Marc Schuckit; Jay A Tischfield; Xiaoling Xuei; Bernice Porjesz; Howard J Edenberg; Alison M Goate; Tatiana Foroud
Journal:  Alcohol Clin Exp Res       Date:  2013-09-09       Impact factor: 3.455

10.  Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants.

Authors:  Can Yang; Cong Li; Henry R Kranzler; Lindsay A Farrer; Hongyu Zhao; Joel Gelernter
Journal:  Hum Genet       Date:  2013-12-03       Impact factor: 4.132
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