Literature DB >> 2332736

Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6.

M G De Simoni1, M Sironi, A De Luigi, A Manfridi, A Mantovani, P Ghezzi.   

Abstract

IL-1 is known to have a central role in the induction of acute-phase response, and some of its activities (including induction of some acute-phase proteins) were reported to be mediated by an induction of IL-6. Administration to rats of 200 ng of human rIL-1 by intracerebroventricular injection resulted in a more marked induction of circulating IL-6 than the same dose of IL-1 administered systemically (intravenously or intraperitoneally). Induction of serum IL-6 by centrally administered IL-1 was also observed in hypophysectomized or adrenalectomized rats, suggesting that activation of the hypothalamus-pituitary-adrenal axis is not essential for this effect of IL-1. IL-6 induction was also observed after pretreatment with indomethacin, indicating that the effect was dissociated from the pyrogenic activity of IL-1. Induction of IL-6 by a central action could represent a novel pathway in IL-1-induced acute-phase response.

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Year:  1990        PMID： 2332736      PMCID： PMC2187888          DOI： 10.1084/jem.171.5.1773

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  27 in total

1.  Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

Authors:  J Gauldie; C Richards; D Harnish; P Lansdorp; H Baumann
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

2.  IL-1 stimulates IL-6 production in endothelial cells.

Authors:  M Sironi; F Breviario; P Proserpio; A Biondi; A Vecchi; J Van Damme; E Dejana; A Mantovani
Journal:  J Immunol       Date:  1989-01-15       Impact factor: 5.422

3.  Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system.

Authors:  F A Houssiau; K Bukasa; C J Sindic; J Van Damme; J Van Snick
Journal:  Clin Exp Immunol       Date:  1988-02       Impact factor: 4.330

4.  The acute phase nature of interleukin 6: studies in Kawasaki disease and other febrile illnesses.

Authors:  Y Ueno; N Takano; H Kanegane; T Yokoi; A Yachie; T Miyawaki; N Taniguchi
Journal:  Clin Exp Immunol       Date:  1989-06       Impact factor: 4.330

5.  On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases.

Authors:  K Frei; U V Malipiero; T P Leist; R M Zinkernagel; M E Schwab; A Fontana
Journal:  Eur J Immunol       Date:  1989-04       Impact factor: 5.532

6.  Tumor necrosis factor and interleukin-1 beta: suppression of food intake by direct action in the central nervous system.

Authors:  C R Plata-Salamán; Y Oomura; Y Kai
Journal:  Brain Res       Date:  1988-05-10       Impact factor: 3.252

7.  Interleukin-1 immunoreactive innervation of the human hypothalamus.

Authors:  C D Breder; C A Dinarello; C B Saper
Journal:  Science       Date:  1988-04-15       Impact factor: 47.728

8.  Pattern differences in experimental fevers induced by endotoxin, endogenous pyrogen, and prostaglandins.

Authors:  A Morimoto; T Nakamori; T Watanabe; T Ono; N Murakami
Journal:  Am J Physiol       Date:  1988-04

9.  Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid.

Authors:  P Gallo; K Frei; C Rordorf; J Lazdins; B Tavolato; A Fontana
Journal:  J Neuroimmunol       Date:  1989-07       Impact factor: 3.478

10.  Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.

Authors:  R Bertini; M Bianchi; P Ghezzi
Journal:  J Exp Med       Date:  1988-05-01       Impact factor: 14.307
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  14 in total

1.  Central injection of nitric oxide synthase inhibitors increases peripheral interleukin-6 and serum amyloid A: involvement of adrenaline from adrenal medulla.

Authors:  D K Song; Y B Im; J S Jung; J J Yan; S O Huh; H W Suh; Y H Kim
Journal:  Br J Pharmacol       Date:  2000-05       Impact factor: 8.739

2.  Increased production of inflammatory cytokines in mild cognitive impairment.

Authors:  Shino Magaki; Claudius Mueller; Cindy Dickson; Wolff Kirsch
Journal:  Exp Gerontol       Date:  2006-11-07       Impact factor: 4.032

3.  Dysregulation of in vitro cytokine production by monocytes during sepsis.

Authors:  C Munoz; J Carlet; C Fitting; B Misset; J P Blériot; J M Cavaillon
Journal:  J Clin Invest       Date:  1991-11       Impact factor: 14.808

4.  Independent down-regulation of central and peripheral tumor necrosis factor production as a result of lipopolysaccharide tolerance in mice.

Authors:  R Faggioni; G Fantuzzi; P Villa; W Buurman; L J van Tits; P Ghezzi
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441

5.  Chlorpromazine specifically inhibits peripheral and brain TNF production, and up-regulates IL-10 production, in mice.

Authors:  M Mengozzi; G Fantuzzi; R Faggioni; A Marchant; M Goldman; S Orencole; B D Clark; M Sironi; F Benigni; P Ghezzi
Journal:  Immunology       Date:  1994-06       Impact factor: 7.397

Review 6.  Peripheral chemo-cytokine profiles in Alzheimer's and Parkinson's diseases.

Authors:  M Reale; N H Greig; M A Kamal
Journal:  Mini Rev Med Chem       Date:  2009-09       Impact factor: 3.862

7.  Intracerebroventricular injection of anti-Fas activates the hypothalamus-pituitary-adrenal axis and induces peripheral interleukin-6 and serum amyloid A in mice: comparison with other ligands of the tumor necrosis factor/nerve growth factor receptor superfamily.

Authors:  F Benigni; S Sacco; L Aloe; P Ghezzi
Journal:  Am J Pathol       Date:  1998-11       Impact factor: 4.307

Review 8.  Systemic lupus erythematosus: immunopathogenesis of neurologic dysfunction.

Authors:  P M Moore; R P Lisak
Journal:  Springer Semin Immunopathol       Date:  1995

9.  Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis.

Authors:  Theodore P Braun; Xinxia Zhu; Marek Szumowski; Gregory D Scott; Aaron J Grossberg; Peter R Levasseur; Kathryn Graham; Sheehan Khan; Sambasivarao Damaraju; William F Colmers; Vickie E Baracos; Daniel L Marks
Journal:  J Exp Med       Date:  2011-11-14       Impact factor: 14.307

10.  Relation between pro-inflammatory cytokines and acetylcholine levels in relapsing-remitting multiple sclerosis patients.

Authors:  Marcella Reale; Federica de Angelis; Marta di Nicola; Elisabetta Capello; Maria di Ioia; Giovanna de Luca; Alessandra Lugaresi; Ada Maria Tata
Journal:  Int J Mol Sci       Date:  2012-10-03       Impact factor: 5.923
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