| Literature DB >> 3259257 |
R Bertini1, M Bianchi, P Ghezzi.
Abstract
To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not by ibuprofen (10 mg/Kg).Entities:
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Year: 1988 PMID： 3259257 PMCID： PMC2188949 DOI： 10.1084/jem.167.5.1708
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307