BACKGROUND: Monitoring of condylomas is an early evidence of population effectiveness of human papillomavirus (HPV) vaccination programs. If reporting could include HPV typing, the contribution by vaccine HPV types to condyloma burden could be monitored. METHODS: A sentinel site for reporting of condyloma including HPV typing was established at the Centre for Sexual Health in Malmö, Sweden. In 2006 to 2009, when there were few HPV vaccines, 621 subjects with condyloma were reported and HPV genotyped. RESULTS: Ninety-four percent of the condylomas contained genital HPV types. Thirty-five different genital HPV types were identified, with HPV6 (62%), HPV16 (13%), and HPV11 (10%) being the most common. At least 1 of the 4 HPV types in the HPV6/11/16/18 vaccine was detected in 77%. High-risk HPV types were more common in females (45%) than among males (27%) (odds ratio, 1.9; confidence interval, 1.3-2.8). Extended testing among subjects initially negative for HPV found 21 patients with cutaneous types of HPV, including a novel type (HPV153). CONCLUSIONS: This report provides a baseline distribution of HPV types in condylomas before the introduction of an HPV vaccination program in this population. Human papillomavirus typing is feasible in routine condyloma reporting.
BACKGROUND: Monitoring of condylomas is an early evidence of population effectiveness of human papillomavirus (HPV) vaccination programs. If reporting could include HPV typing, the contribution by vaccine HPV types to condyloma burden could be monitored. METHODS: A sentinel site for reporting of condyloma including HPV typing was established at the Centre for Sexual Health in Malmö, Sweden. In 2006 to 2009, when there were few HPV vaccines, 621 subjects with condyloma were reported and HPV genotyped. RESULTS: Ninety-four percent of the condylomas contained genital HPV types. Thirty-five different genital HPV types were identified, with HPV6 (62%), HPV16 (13%), and HPV11 (10%) being the most common. At least 1 of the 4 HPV types in the HPV6/11/16/18 vaccine was detected in 77%. High-risk HPV types were more common in females (45%) than among males (27%) (odds ratio, 1.9; confidence interval, 1.3-2.8). Extended testing among subjects initially negative for HPV found 21 patients with cutaneous types of HPV, including a novel type (HPV153). CONCLUSIONS: This report provides a baseline distribution of HPV types in condylomas before the introduction of an HPV vaccination program in this population. Human papillomavirus typing is feasible in routine condyloma reporting.
Authors: Laura Sichero; Mariam El-Zein; Emily M Nunes; Silvaneide Ferreira; Eduardo L Franco; Luisa L Villa Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-04-04 Impact factor: 4.254
Authors: Christine M Pierce Campbell; Jane L Messina; Mark H Stoler; Drazen M Jukic; Massimo Tommasino; Tarik Gheit; Dana E Rollison; Laura Sichero; Bradley A Sirak; Donna J Ingles; Martha Abrahamsen; Beibei Lu; Luisa L Villa; Eduardo Lazcano-Ponce; Anna R Giuliano Journal: J Clin Virol Date: 2013-10-16 Impact factor: 3.168
Authors: Hanna Bergman; Brian S Buckley; Gemma Villanueva; Jennifer Petkovic; Chantelle Garritty; Vittoria Lutje; Alina Ximena Riveros-Balta; Nicola Low; Nicholas Henschke Journal: Cochrane Database Syst Rev Date: 2019-11-22
Authors: Christine M Pierce Campbell; Tarik Gheit; Massimo Tommasino; Hui-Yi Lin; B Nelson Torres; Jane L Messina; Mark H Stoler; Dana E Rollison; Bradley A Sirak; Martha Abrahamsen; Roberto J Carvalho da Silva; Laura Sichero; Luisa L Villa; Eduardo Lazcano-Ponce; Anna R Giuliano Journal: Virology Date: 2016-08-10 Impact factor: 3.616
Authors: Davit Bzhalava; Hanna Johansson; Johanna Ekström; Helena Faust; Birgitta Möller; Carina Eklund; Peter Nordin; Bo Stenquist; John Paoli; Bengt Persson; Ola Forslund; Joakim Dillner Journal: PLoS One Date: 2013-06-28 Impact factor: 3.240