Christine M Pierce Campbell1, Tarik Gheit2, Massimo Tommasino2, Hui-Yi Lin3, B Nelson Torres4, Jane L Messina5, Mark H Stoler6, Dana E Rollison1, Bradley A Sirak1, Martha Abrahamsen1, Roberto J Carvalho da Silva7, Laura Sichero8, Luisa L Villa9, Eduardo Lazcano-Ponce10, Anna R Giuliano11. 1. Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA. 2. Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France. 3. Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA. 4. Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA. 5. Departments of Anatomic Pathology and Cutaneous Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Departments of Oncologic Sciences, Pathology, and Cell Biology and Dermatology, University of South Florida Morsani College of Medicine, Tampa, FL, USA. 6. Department of Pathology, University of Virginia Health System, Charlottesville, VA, USA. 7. Center for Reference and Training in STD/AIDS, São Paulo, Brazil. 8. Center for Translational Research in Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil. 9. Center for Translational Research in Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil; Department of Radiology and Oncology, School of Medicine, Universidade de São Paulo, São Paulo, Brazil. 10. Center for Population Health Research, Instituto Nacional de Salud Pública (INSP), Cuernavaca, México. 11. Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address: Anna.Giuliano@moffitt.org.
Abstract
BACKGROUND: Cutaneous human papillomaviruses (HPVs) increase the risk of non-melanoma skin cancer in sun-exposed skin. We examined the role of beta-HPV in the development of male external genital lesions (EGLs), a sun-unexposed site. METHODS: In this nested case-control study (67 men with pathologically-confirmed EGLs and 134 controls), exfoliated cells collected from the surface of lesions and normal genital skin 0, 6, and 12 months preceding EGL development were tested for beta-HPV DNA using a type-specific multiplex genotyping assay. Beta-HPV prevalence was estimated and conditional logistic regression was used to evaluate the association with condyloma, the most common EGL. RESULTS: While beta-HPV prevalence among controls remained stable, the prevalence among cases was lowest on the surface of lesion. Detecting beta-HPV on the normal genital skin was not associated with the presence or development of condyloma. CONCLUSIONS: Cutaneous beta-HPV does not appear to be contributing to pathogenesis in male genital skin.
BACKGROUND:Cutaneous human papillomaviruses (HPVs) increase the risk of non-melanoma skin cancer in sun-exposed skin. We examined the role of beta-HPV in the development of male external genital lesions (EGLs), a sun-unexposed site. METHODS: In this nested case-control study (67 men with pathologically-confirmed EGLs and 134 controls), exfoliated cells collected from the surface of lesions and normal genital skin 0, 6, and 12 months preceding EGL development were tested for beta-HPV DNA using a type-specific multiplex genotyping assay. Beta-HPV prevalence was estimated and conditional logistic regression was used to evaluate the association with condyloma, the most common EGL. RESULTS: While beta-HPV prevalence among controls remained stable, the prevalence among cases was lowest on the surface of lesion. Detecting beta-HPV on the normal genital skin was not associated with the presence or development of condyloma. CONCLUSIONS: Cutaneous beta-HPV does not appear to be contributing to pathogenesis in male genital skin.
Authors: Markus Schmitt; I G Bravo; Peter J F Snijders; Lutz Gissmann; Michael Pawlita; Tim Waterboer Journal: J Clin Microbiol Date: 2006-02 Impact factor: 5.948
Authors: Christine M Pierce Campbell; Jane L Messina; Mark H Stoler; Drazen M Jukic; Massimo Tommasino; Tarik Gheit; Dana E Rollison; Laura Sichero; Bradley A Sirak; Donna J Ingles; Martha Abrahamsen; Beibei Lu; Luisa L Villa; Eduardo Lazcano-Ponce; Anna R Giuliano Journal: J Clin Virol Date: 2013-10-16 Impact factor: 3.168
Authors: Dana E Rollison; Michael Pawlita; Anna R Giuliano; Michelle R Iannacone; Vernon K Sondak; Jane L Messina; C Wayne Cruse; Neil Alan Fenske; Lewis Frank Glass; Matthew Kienstra; Kristina M Michael; Tim Waterboer; Tarik Gheit; Massimo Tommasino Journal: Int J Cancer Date: 2008-11-15 Impact factor: 7.396
Authors: Michelle R Iannacone; Tarik Gheit; Tim Waterboer; Anna R Giuliano; Jane L Messina; Neil A Fenske; Basil S Cherpelis; Vernon K Sondak; Richard G Roetzheim; Sandra Ferrer-Gil; Kristina M Michael; Sandrine McKay-Chopin; Michael Pawlita; Massimo Tommasino; Dana E Rollison Journal: J Invest Dermatol Date: 2013-01-10 Impact factor: 8.551