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Literature DB >> 23324626

SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.

Olivier Binda¹, Ana Sevilla, Gary LeRoy, Ihor R Lemischka, Benjamin A Garcia, Stéphane Richard.

Abstract

The histone H2A variant H2AZ is an essential chromatin signaling factor. Herein, we report that H2AZ is monomethylated at lysine 7 (H2AZK7me1) by the lysine methyltransferase SETD6. We observed that methylation of H2AZ increased noticeably upon cellular differentiation of mouse embryonic stem cells (mESCs). H2AZK7me1 and the repressive H3K27me3 mark were found near the transcriptional start sites of differentiation marker genes, but were removed upon retinoic acid-induced cellular differentiation. The depletion of Setd6 in mESCs led to cellular differentiation, compromised self-renewal, and poor clonogenicity. These findings demonstrate that mESCs require Setd6 for self-renewal and portray H2AZK7me1 as a marker of cellular differentiation.

Entities: Chemical Gene Species

Keywords: H2AZ; SETD6; embryonic stem cells; histone variant; lysine methylation; lysine methyltransferase

Mesh：

Substances：

Year: 2013 PMID： 23324626 PMCID： PMC3592903 DOI： 10.4161/epi.23416

Source DB: PubMed Journal: Epigenetics ISSN： 1559-2294 Impact factor: 4.528

18 in total

Review 1. Unsafe SETs: histone lysine methyltransferases and cancer.

Authors: Robert Schneider; Andrew J Bannister; Tony Kouzarides
Journal: Trends Biochem Sci Date: 2002-08 Impact factor: 13.807

2. Dissecting self-renewal in stem cells with RNA interference.

Authors: Natalia Ivanova; Radu Dobrin; Rong Lu; Iulia Kotenko; John Levorse; Christina DeCoste; Xenia Schafer; Yi Lun; Ihor R Lemischka
Journal: Nature Date: 2006-06-11 Impact factor: 49.962

3. Polycomb complexes repress developmental regulators in murine embryonic stem cells.

Authors: Laurie A Boyer; Kathrin Plath; Julia Zeitlinger; Tobias Brambrink; Lea A Medeiros; Tong Ihn Lee; Stuart S Levine; Marius Wernig; Adriana Tajonar; Mridula K Ray; George W Bell; Arie P Otte; Miguel Vidal; David K Gifford; Richard A Young; Rudolf Jaenisch
Journal: Nature Date: 2006-04-19 Impact factor: 49.962

4. High-resolution profiling of histone methylations in the human genome.

Authors: Artem Barski; Suresh Cuddapah; Kairong Cui; Tae-Young Roh; Dustin E Schones; Zhibin Wang; Gang Wei; Iouri Chepelev; Keji Zhao
Journal: Cell Date: 2007-05-18 Impact factor: 41.582

5. ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease.

Authors: Hoon Ryu; Junghee Lee; Sean W Hagerty; Byoung Yul Soh; Sara E McAlpin; Kerry A Cormier; Karen M Smith; Robert J Ferrante
Journal: Proc Natl Acad Sci U S A Date: 2006-12-01 Impact factor: 11.205

6. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment.

Authors: Menno P Creyghton; Styliani Markoulaki; Stuart S Levine; Jacob Hanna; Michael A Lodato; Ky Sha; Richard A Young; Rudolf Jaenisch; Laurie A Boyer
Journal: Cell Date: 2008-11-06 Impact factor: 41.582

7. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.

Authors: Keisuke Nimura; Kiyoe Ura; Hidetaka Shiratori; Masato Ikawa; Masaru Okabe; Robert J Schwartz; Yasufumi Kaneda
Journal: Nature Date: 2009-05-31 Impact factor: 49.962

8. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.

Authors: Dung-Fang Lee; Jie Su; Yen-Sin Ang; Xonia Carvajal-Vergara; Sonia Mulero-Navarro; Carlos F Pereira; Julian Gingold; Hung-Liang Wang; Ruiying Zhao; Ana Sevilla; Henia Darr; Andrew J K Williamson; Betty Chang; Xiaohong Niu; Francesca Aguilo; Elsa R Flores; Yuh-Pyng Sher; Mien-Chie Hung; Anthony D Whetton; Bruce D Gelb; Kateri A Moore; Hans-Willem Snoeck; Avi Ma'ayan; Christoph Schaniel; Ihor R Lemischka
Journal: Cell Stem Cell Date: 2012-08-03 Impact factor: 24.633

9. Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin.

Authors: Elizabeth Sarcinella; Philip C Zuzarte; Priscilla N I Lau; Ryan Draker; Peter Cheung
Journal: Mol Cell Biol Date: 2007-07-16 Impact factor: 4.272

10. The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken.

Authors: Kimberley Bruce; Fiona A Myers; Evangelia Mantouvalou; Pascal Lefevre; Ian Greaves; Constanze Bonifer; David J Tremethick; Alan W Thorne; Colyn Crane-Robinson
Journal: Nucleic Acids Res Date: 2005-10-04 Impact factor: 16.971

26 in total

1. The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation.

Authors: Michal Feldman; Zlata Vershinin; Inna Goliand; Natalie Elia; Dan Levy
Journal: Proc Natl Acad Sci U S A Date: 2019-01-08 Impact factor: 11.205

2. Cell cycle-dependent degradation of the methyltransferase SETD3 attenuates cell proliferation and liver tumorigenesis.

Authors: Xiaoqing Cheng; Yuan Hao; Wenjie Shu; Mengjie Zhao; Chen Zhao; Yuan Wu; Xiaodan Peng; Pinfang Yao; Daibiao Xiao; Guoliang Qing; Zhengying Pan; Lei Yin; Desheng Hu; Hai-Ning Du
Journal: J Biol Chem Date: 2017-04-25 Impact factor: 5.157

SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.

Review 1. Unsafe SETs: histone lysine methyltransferases and cancer.

2. Dissecting self-renewal in stem cells with RNA interference.

3. Polycomb complexes repress developmental regulators in murine embryonic stem cells.

4. High-resolution profiling of histone methylations in the human genome.

5. ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease.

6. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment.

7. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.

8. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.

9. Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin.

10. The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken.

1. The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation.

2. Cell cycle-dependent degradation of the methyltransferase SETD3 attenuates cell proliferation and liver tumorigenesis.

3. High-Throughput Quantitative Top-Down Proteomics: Histone H4.

4. Transcriptional regulation mediated by H2A.Z via ANP32e-dependent inhibition of protein phosphatase 2A.

Review 5. Post-translational modifications of the histone variant H2AZ.

6. Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12.

Review 7. Protein methylation at the surface and buried deep: thinking outside the histone box.

Review 8. Emerging roles of lysine methylation on non-histone proteins.

Review 9. Comprehensive Catalog of Currently Documented Histone Modifications.

10. PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/β-Catenin Pathway.