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Literature DB >> 23318268

Changes in gastrointestinal tract function and structure in functional dyspepsia.

Abstract

Functional dyspepsia is an extremely common disorder of gastrointestinal function. The disorder is thought to be heterogeneous, with different pathophysiological mechanisms underlying varied symptom patterns. A diversity of changes in gastrointestinal tract function and structure has been described in functional dyspepsia. These involve alterations in the stomach, such as impaired accommodation, delayed gastric emptying and hypersensitivity, and alterations in the duodenum, such as increased sensitivity to duodenal acid and/or lipids and low-grade inflammation. In this Review, we summarize all these abnormalities in an attempt to provide an integrated overview of the pathophysiological mechanisms in functional dyspepsia.

Entities: Chemical Disease

Mesh：

Year: 2013 PMID： 23318268 DOI： 10.1038/nrgastro.2012.255

Source DB: PubMed Journal: Nat Rev Gastroenterol Hepatol ISSN： 1759-5045 Impact factor: 46.802

97 in total

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Authors: Lukas Van Oudenhove; Qasim Aziz
Journal: Nat Rev Gastroenterol Hepatol Date: 2013-01-29 Impact factor: 46.802

45 in total

1. Specific dyspeptic symptoms are associated with poor response to therapy in patients with gastroesophageal reflux disease.

Authors: A D'Alessandro; F P Zito; M Pesce; P Andreozzi; E Efficie; M Cargiolli; F Maione; G D De Palma; R Cuomo; G Sarnelli
Journal: United European Gastroenterol J Date: 2016-07-07 Impact factor: 4.623

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Authors: Kumiko Nakamura; Toshihiko Tomita; Tadayuki Oshima; Haruki Asano; Takahisa Yamasaki; Takuya Okugawa; Takashi Kondo; Tomoaki Kono; Katsuyuki Tozawa; Yoshio Ohda; Hirokazu Fukui; Fukushima Kazuhito; Shozo Hirota; Jiro Watari; Hiroto Miwa
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Authors: Adil E Bharucha; Michael Camilleri; Duane D Burton; Shannon L Thieke; Kelly J Feuerhak; Ananda Basu; Alan R Zinsmeister
Journal: Am J Gastroenterol Date: 2014-11-18 Impact factor: 10.864

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Authors: John H Winston; Sushil K Sarna
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2016-05-05 Impact factor: 4.052

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Journal: Gut Date: 2017-02-21 Impact factor: 23.059

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Authors: Jan Tack; Nicholas J Talley
Journal: Nat Rev Gastroenterol Hepatol Date: 2013-02-12 Impact factor: 46.802

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Authors: H Vanheel; F Carbone; L Valvekens; M Simren; H Tornblom; T Vanuytsel; L Van Oudenhove; J Tack
Journal: Am J Gastroenterol Date: 2016-12-13 Impact factor: 10.864

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Authors: Rajan Singh; Uday C Ghoshal; Sushil Kumar; Balraj Mittal
Journal: Indian J Gastroenterol Date: 2017-09-30

10. Altered duodenal bile salt concentration and receptor expression in functional dyspepsia.

Authors: Dorien Beeckmans; Danny Riethorst; Patrick Augustijns; Tim Vanuytsel; Ricard Farré; Jan Tack; Hanne Vanheel
Journal: United European Gastroenterol J Date: 2018-09-04 Impact factor: 4.623