Literature DB >> 2331786

Transforming growth factor beta 1 is a potent survival factor for rat embryo motoneurons in culture.

J C Martinou1, A Le Van Thai, A Valette, M J Weber.   

Abstract

We have studied the effects of transforming growth factor beta 1 (TGF beta 1) on the survival of embryonic motoneurons in culture. For this purpose, E14 rat embryo motoneurons were purified to more than 90% homogeneity by cell sorting and cultured at low density on monolayers of cortex astrocytes. Subnanomolar concentrations of TGF beta 1 (40-500 pM) increased the survival of motoneurons 2-fold after 9-11 days in culture. The increase in choline acetyltransferase (ChAT) activity per culture caused by TGF beta 1 was attributable to its effects on survival. Comparable results were found with motoneurons cultured on lysed astrocytes, suggesting that the effects of the factor are not mediated by non-neuronal cells, but that motoneurons are a target for TGF beta 1.

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Year:  1990        PMID： 2331786     DOI： 10.1016/0165-3806(90)90233-o

Source DB:  PubMed          Journal:  Brain Res Dev Brain Res        ISSN： 0165-3806


  21 in total

1.  Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo.

Authors:  J Strelau; A Sullivan; M Böttner; P Lingor; E Falkenstein; C Suter-Crazzolara; D Galter; J Jaszai; K Krieglstein; K Unsicker
Journal:  J Neurosci       Date:  2000-12-01       Impact factor: 6.167

Review 2.  TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function.

Authors:  Emily A Meyers; John A Kessler
Journal:  Cold Spring Harb Perspect Biol       Date:  2017-08-01       Impact factor: 10.005

3.  Localization of transforming growth factor beta in association with neuromuscular junctions in adult human muscle.

Authors:  M Toepfer; P Fischer; A Abicht; H Lochmüller; D Pongratz; W Müller-Felber
Journal:  Cell Mol Neurobiol       Date:  1999-04       Impact factor: 5.046

4.  Cytokine Responses in Severe Traumatic Brain Injury: Where There Is Smoke, Is There Fire?

Authors:  Colin Casault; Abdulaziz S Al Sultan; Mohammad Banoei; Philippe Couillard; Andreas Kramer; Brent W Winston
Journal:  Neurocrit Care       Date:  2019-02       Impact factor: 3.210

5.  Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1.

Authors:  Zhihua Feng; Chien-Ping Ko
Journal:  J Neurosci       Date:  2008-09-24       Impact factor: 6.167

6.  Glial cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurons.

Authors:  K Krieglstein; P Henheik; L Farkas; J Jaszai; D Galter; K Krohn; K Unsicker
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

7.  Endogenous TGFβ1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats.

Authors:  Xu-Yang Wang; Ying-Chun Ba; Liu-Lin Xiong; Xiao-Li Li; Yu Zou; Ye-Chun Zhu; Xin-Fu Zhou; Ting-Hua Wang; Fang Wang; Heng-Li Tian; Jin-Tao Li
Journal:  Neurochem Res       Date:  2015-08-08       Impact factor: 3.996

8.  Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy.

Authors:  Muragundla Anjaneyulu; Alison Berent-Spillson; Tatsuya Inoue; Joungil Choi; Kay Cherian; James W Russell
Journal:  Exp Neurol       Date:  2008-03-02       Impact factor: 5.330

9.  Transforming growth factor-beta 1 in experimental autoimmune neuritis. Cellular localization and time course.

Authors:  R Kiefer; K Funa; T Schweitzer; S Jung; O Bourde; K V Toyka; H P Hartung
Journal:  Am J Pathol       Date:  1996-01       Impact factor: 4.307

10.  Serum cytokine levels in patients with Alzheimer's disease.

Authors:  C C Chao; T A Ala; S Hu; K B Crossley; R E Sherman; P K Peterson; W H Frey
Journal:  Clin Diagn Lab Immunol       Date:  1994-07
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