Literature DB >> 23317514

mTOR in aging, metabolism, and cancer.

Marion Cornu1, Verena Albert, Michael N Hall.   

Abstract

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular organisms, TOR regulates cell growth and metabolism in response to nutrients, growth factors and cellular energy. Deregulation of TOR signaling alters whole body metabolism and causes age-related disease. This review describes the most recent advances in TOR signaling with a particular focus on mammalian TOR (mTOR) in metabolic tissues vis-a-vis aging, obesity, type 2 diabetes, and cancer.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23317514     DOI： 10.1016/j.gde.2012.12.005

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  228 in total

Review 1.  mTOR in health and in sickness.

Authors:  Dritan Liko; Michael N Hall
Journal:  J Mol Med (Berl)       Date:  2015-09-22       Impact factor: 4.599

2.  When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?

Authors:  Noriko N Yokoyama; Andria Denmon; Edward M Uchio; Mark Jordan; Dan Mercola; Xiaolin Zi
Journal:  Curr Pharmacol Rep       Date:  2015-04-14

3.  FKBPs and the Akt/mTOR pathway.

Authors:  Felix Hausch; Christian Kozany; Marily Theodoropoulou; Anne-Katrin Fabian
Journal:  Cell Cycle       Date:  2013-07-01       Impact factor: 4.534

Review 4.  Sphingolipids and lifespan regulation.

Authors:  Xinhe Huang; Bradley R Withers; Robert C Dickson
Journal:  Biochim Biophys Acta       Date:  2013-08-15

5.  Proximal tubules forget "self-eating" when they meet Western meals.

Authors:  Ken Inoki
Journal:  J Am Soc Nephrol       Date:  2013-10-03       Impact factor: 10.121

6.  Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.

Authors:  Karl Katholnig; Birgit Schütz; Stephanie D Fritsch; David Schörghofer; Monika Linke; Nyamdelger Sukhbaatar; Julia M Matschinger; Daniela Unterleuthner; Martin Hirtl; Michaela Lang; Merima Herac; Andreas Spittler; Andreas Bergthaler; Gernot Schabbauer; Michael Bergmann; Helmut Dolznig; Markus Hengstschläger; Mark A Magnuson; Mario Mikula; Thomas Weichhart
Journal:  JCI Insight       Date:  2019-10-17

7.  Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity.

Authors:  Irina Mikhailovna Bochkis; Soona Shin; Klaus Hermann Kaestner
Journal:  Mol Metab       Date:  2013-08-24       Impact factor: 7.422

8.  Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).

Authors:  Christoph Garbers; Fabian Kuck; Samadhi Aparicio-Siegmund; Kirstin Konzak; Mareike Kessenbrock; Annika Sommerfeld; Dieter Häussinger; Philipp A Lang; Dirk Brenner; Tak W Mak; Stefan Rose-John; Frank Essmann; Klaus Schulze-Osthoff; Roland P Piekorz; Jürgen Scheller
Journal:  Cell Cycle       Date:  2013-09-18       Impact factor: 4.534

Review 9.  Autophagy and aging.

Authors:  Nuria Martinez-Lopez; Diana Athonvarangkul; Rajat Singh
Journal:  Adv Exp Med Biol       Date:  2015       Impact factor: 2.622

10.  Comparison of rapamycin schedules in mice on high-fat diet.

Authors:  Olga V Leontieva; Geraldine M Paszkiewicz; Mikhail V Blagosklonny
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.