Literature DB >> 23314929

Specific activity of electron-beam synthesis immobilized hyaluronidase on G-CSF induced mobilization of bone marrow progenitor cells.

A M Dygai1, G N Zyuz'kov, V V Zhdanov, E V Udut, L A Miroshnichenko, E V Simanina, T Yu Khrichkova, M Yu Minakova, P G Madonov.   

Abstract

The effects of nanotechnology (electron-beam) -PEGylated (or immobilized; Im) hyaluronidase (HD) on the state of the pool of bone marrow progenitor cells and their mobilization induced by granulocyte colony stimulating factor (G-CSF) were studied. A high specific activity of the drug Im-HD on progenitor cells of different classes was demonstrated using parenteral and enteral administration. An increase in the content of erythroid (E), granulomonocytic (GM), fibroblast (F) colony-forming units (CFU) and mesenchymal stem cells (MSC) in bone marrow was shown, as well as G-CSF-induced stimulation of mobilization of precursors into the peripheral blood under the influence of Im-HD. The detected activity of this novel drug on progenitor cells indicates the potential for a safe and highly effective treatment for hematology practice and regenerative medicine.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23314929     DOI： 10.1007/s12015-012-9423-2

Source DB:  PubMed          Journal:  Stem Cell Rev Rep        ISSN： 2629-3277            Impact factor:   5.739


  26 in total

1.  Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential.

Authors:  Pieternella S in 't Anker; Willy A Noort; Sicco A Scherjon; Carin Kleijburg-van der Keur; Alwine B Kruisselbrink; Rutger L van Bezooijen; Willem Beekhuizen; Roelof Willemze; Humphrey H H Kanhai; Willem E Fibbe
Journal:  Haematologica       Date:  2003-08       Impact factor: 9.941

2.  Mechanisms of hepatoprotective effect of preparation containing superlow doses of antibodies to granulocytic colony-stimulating factor.

Authors:  O I Epstein; G N Zyuz'kov; N V Sotnikova; L A Stavrova; T I Fomina; T V Vetoshkina; S A Sergeeva; T Yu Dubskaya; A M Dygai; E D Gol'dberg
Journal:  Bull Exp Biol Med       Date:  2005-11       Impact factor: 0.804

Review 3.  Formulation of Neulasta (pegfilgrastim).

Authors:  Deirdre Murphy Piedmonte; Michael J Treuheit
Journal:  Adv Drug Deliv Rev       Date:  2007-08-11       Impact factor: 15.470

4.  Role of hyaluronidase in the regulation of functions of mesenchymal precursor cells.

Authors:  E D Goldberg; A M Dygai; G N Zyuz'kov; V V Zhdanov; E V Simanina; L A Gur'yantseva
Journal:  Bull Exp Biol Med       Date:  2007-04       Impact factor: 0.804

5.  Mechanisms of therapeutic effects of granulocytic colony-stimulating factor in experimental diabetes mellitus.

Authors:  E D Gol'dberg; A M Dygai; V V Zhdanov; G N Zyuz'kov; N N Ermakova; T V Vetoshkina; T I Fomina; L A Ermolaeva; T Yu Dubskaya
Journal:  Bull Exp Biol Med       Date:  2008-10       Impact factor: 0.804

6.  Mechanisms of mobilization of mesenchymal precursor cell under the effect of granulocytic colony-stimulating factor and hyaluronidase.

Authors:  E D Goldberg; A M Dygai; G N Zyuz'kov; V V Zhdanov
Journal:  Bull Exp Biol Med       Date:  2007-12       Impact factor: 0.804

7.  Mobilization of progenitor cells into the blood by immobilized granulocytic colony-stimulating factor.

Authors:  A M Dygai; E I Vereshchagin; G N Zyuz'kov; V V Zhdanov; P G Madonov; E V Simanina; L A Stavrova; E V Udut; T Yu Khrichkova; L A Miroshnichenko; M Yu Minakova; N N Ermakova; T V Firsova
Journal:  Bull Exp Biol Med       Date:  2009-04       Impact factor: 0.804

8.  Effect of transplantation of peripheral blood mononuclears obtained using granulocytic colony-stimulating factor and hyaluronidase on regeneration of hemopoietic tissue during myelosuppression.

Authors:  A M Dygai; G N Zyuz'kov; V V Zhdanov; E V Simanina; L A Stavrova; E V Udut; T Yu Khrichkova; M Yu Minakova; N N Ermakova; T V Firsova
Journal:  Bull Exp Biol Med       Date:  2009-07       Impact factor: 0.804

9.  Pharmacological properties of granulocytic colony-stimulating factor pegylated using electron beam synthesis nanotechnologies.

Authors:  A M Dygai; G N Zyuz'kov; V V Zhdanov; P G Madonov; E V Udut; L A Miroshnichenko; T Yu Khrichkova; E V Simanina; L A Stavrova; A V Artamonov; A A Bekarev; D N Kinsht; A V Chaikovskiy; T S Markova; R V Gurto
Journal:  Bull Exp Biol Med       Date:  2011-11       Impact factor: 0.804

Review 10.  Devising a pathway for hyaluronan catabolism: are we there yet?

Authors:  Robert Stern
Journal:  Glycobiology       Date:  2003-09-26       Impact factor: 4.313
View more
  1 in total

1.  Comparison of the efficacy of hematopoietic stem cell mobilization regimens: a systematic review and network meta-analysis of preclinical studies.

Authors:  Chengxin Luo; Li Wang; Guixian Wu; Xiangtao Huang; Yali Zhang; Yanni Ma; Mingling Xie; Yanni Sun; Yarui Huang; Zhen Huang; Qiuyue Song; Hui Li; Yu Hou; Xi Li; Shuangnian Xu; Jieping Chen
Journal:  Stem Cell Res Ther       Date:  2021-05-29       Impact factor: 6.832
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.