Literature DB >> 23314571

The multiple faces of proteinkinase R in antiviral defense.

Muhammad Munir1, Mikael Berg.   

Abstract

Various pattern recognition receptors (PRRs) have been implicated in the detection of viral RNA and subsequent interferon (IFN) gene expression, including the double-stranded RNA-dependent proteinkinase R (PKR). Now, a novel role of PKR has been unveiled, as it was shown that, upon the infection with certain viruses, PKR is crucial for the integrity of newly synthesized IFN mRNA, thereby generating an optimal host antiviral immune response. There is a need of future studies to investigate additional roles of PKR in innate immunity and the molecular understanding of this novel function of PKR.

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Year:  2013        PMID： 23314571      PMCID： PMC3544753          DOI： 10.4161/viru.23134

Source DB:  PubMed          Journal:  Virulence        ISSN： 2150-5594            Impact factor:   5.882


  25 in total

1.  The (2'-5') oligoadenylate (pppA2'-5'A2'-5'A) synthetase and protein kinase(s) from interferon-treated cells.

Authors:  A G Hovanessian; I M Kerr
Journal:  Eur J Biochem       Date:  1979-02-01

Review 2.  Innate recognition of viruses.

Authors:  Andreas Pichlmair; Caetano Reis e Sousa
Journal:  Immunity       Date:  2007-09       Impact factor: 31.745

Review 3.  Signal integration via PKR.

Authors:  B R Williams
Journal:  Sci STKE       Date:  2001-07-03

4.  NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase.

Authors:  M Zamanian-Daryoush; T H Mogensen; J A DiDonato; B R Williams
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

5.  Interferon inhibits viral protein synthesis in L cells infected with vaccinia virus.

Authors:  D H Metz; M Esteban
Journal:  Nature       Date:  1972-08-18       Impact factor: 49.962

6.  Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells.

Authors:  I W Jeffrey; S Kadereit; E F Meurs; T Metzger; M Bachmann; M Schwemmle; A G Hovanessian; M J Clemens
Journal:  Exp Cell Res       Date:  1995-05       Impact factor: 3.905

7.  Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR.

Authors:  Yitzhak Ben-Asouli; Yona Banai; Yehuda Pel-Or; Alexei Shir; Raymond Kaempfer
Journal:  Cell       Date:  2002-01-25       Impact factor: 41.582

8.  Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.

Authors:  G S Feng; K Chong; A Kumar; B R Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

9.  Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.

Authors:  Sandra S Diebold; Maria Montoya; Hermann Unger; Lena Alexopoulou; Polly Roy; Linsey E Haswell; Aymen Al-Shamkhani; Richard Flavell; Persephone Borrow; Caetano Reis e Sousa
Journal:  Nature       Date:  2003-06-22       Impact factor: 49.962

10.  Deadenylation of interferon-beta mRNA is mediated by both the AU-rich element in the 3'-untranslated region and an instability sequence in the coding region.

Authors:  Muriel Pasté; Georges Huez; Véronique Kruys
Journal:  Eur J Biochem       Date:  2003-04
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  44 in total

Review 1.  Regulation of Posttranslational Modifications of HMGB1 During Immune Responses.

Authors:  Yiting Tang; Xin Zhao; Daniel Antoine; Xianzhong Xiao; Haichao Wang; Ulf Andersson; Timothy R Billiar; Kevin J Tracey; Ben Lu
Journal:  Antioxid Redox Signal       Date:  2016-02-05       Impact factor: 8.401

Review 2.  The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus.

Authors:  Lisi Amsler; Marieke Verweij; Victor R DeFilippis
Journal:  J Mol Biol       Date:  2013-09-05       Impact factor: 5.469

3.  Kinetic Differences and Synergistic Antiviral Effects Between Type I and Type III Interferon Signaling Indicate Pathway Independence.

Authors:  Emily A Voigt; John Yin
Journal:  J Interferon Cytokine Res       Date:  2015-05-04       Impact factor: 2.607

4.  Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective.

Authors:  Nico Marr; Stuart E Turvey; Nathalie Grandvaux
Journal:  Trends Microbiol       Date:  2013-10-09       Impact factor: 17.079

5.  Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer.

Authors:  Edward M Kennedy; Adam W Whisnant; Anand V R Kornepati; Joy B Marshall; Hal P Bogerd; Bryan R Cullen
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-30       Impact factor: 11.205

6.  Exacerbated Apoptosis of Cells Infected with Infectious Bursal Disease Virus upon Exposure to Interferon Alpha.

Authors:  Liliana L Cubas-Gaona; Elisabet Diaz-Beneitez; Marina Ciscar; José F Rodríguez; Dolores Rodríguez
Journal:  J Virol       Date:  2018-05-14       Impact factor: 5.103

Review 7.  Interferon-stimulated genes: a complex web of host defenses.

Authors:  William M Schneider; Meike Dittmann Chevillotte; Charles M Rice
Journal:  Annu Rev Immunol       Date:  2014-02-06       Impact factor: 28.527

8.  Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain.

Authors:  Paulino Barragán-Iglesias; Úrzula Franco-Enzástiga; Vivekanand Jeevakumar; Stephanie Shiers; Andi Wangzhou; Vinicio Granados-Soto; Zachary T Campbell; Gregory Dussor; Theodore J Price
Journal:  J Neurosci       Date:  2020-04-03       Impact factor: 6.167

9.  Response of Three Different Viruses to Interferon Priming and Dithiothreitol Treatment of Avian Cells.

Authors:  Irene Lostalé-Seijo; José Martínez-Costas; Javier Benavente
Journal:  J Virol       Date:  2016-08-26       Impact factor: 5.103

10.  Nod-like receptor X-1 is required for rhinovirus-induced barrier dysfunction in airway epithelial cells.

Authors:  Benjamin L Unger; Shyamala Ganesan; Adam T Comstock; Andrea N Faris; Marc B Hershenson; Uma S Sajjan
Journal:  J Virol       Date:  2014-01-15       Impact factor: 5.103
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